SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ipy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		5 / 9 PHE A 189
TYR A  67
ILE A 224
VAL A 202
ILE A 269
 None
 1.14A 1gebA-5ipyA:
undetectable		 1gebA-5ipyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		5 / 9 LEU A 281
HIS A 276
LEU A 287
HIS A 164
GLY A 314
 None
None
None
None
FAD  A 502 ( 4.3A)
 1.40A 1mjlA-5ipyA:
undetectable
1mjlB-5ipyA:
undetectable		 1mjlA-5ipyA:
14.42
1mjlB-5ipyA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		5 / 12 TYR A 417
ILE A 370
GLY A  74
SER A  96
HIS A 404
 None
 1.20A 1nbhA-5ipyA:
2.3		 1nbhA-5ipyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		5 / 12 TYR A 417
ILE A 370
GLY A  74
SER A  96
HIS A 404
 None
 1.19A 1nbhC-5ipyA:
undetectable		 1nbhC-5ipyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		5 / 12 TYR A 417
ILE A 370
GLY A  74
SER A  96
HIS A 404
 None
 1.19A 1nbhD-5ipyA:
2.1		 1nbhD-5ipyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		5 / 12 ILE A 107
ALA A  16
ASP A 326
PHE A 322
PRO A  75
 None
None
None
FAD  A 502 (-4.8A)
None
 1.22A 1re7B-5ipyA:
undetectable		 1re7B-5ipyA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		4 / 8 TYR A 207
VAL A 366
ARG A 413
GLU A 210
 NAP  A 501 (-3.7A)
None
NAP  A 501 (-4.0A)
None
 0.98A 1s3zA-5ipyA:
undetectable
1s3zB-5ipyA:
undetectable		 1s3zA-5ipyA:
14.35
1s3zB-5ipyA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		5 / 10 LEU A 337
ALA A 335
ILE A 336
GLN A  17
PHE A  21
 None
 1.16A 1xp0A-5ipyA:
undetectable		 1xp0A-5ipyA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		3 / 3 ASP A  83
ASP A 385
ASN A 323
 None
 0.67A 2bm9D-5ipyA:
undetectable		 2bm9D-5ipyA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		5 / 11 LEU A 103
THR A 321
ILE A 107
MET A  66
LEU A 293
 None
FAD  A 502 (-2.6A)
None
FAD  A 502 (-4.4A)
None
 1.42A 2n27A-5ipyA:
0.0		 2n27A-5ipyA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		5 / 12 LEU A 313
GLY A  14
GLN A  17
PHE A 278
LEU A 281
 None
 1.32A 2w8yA-5ipyA:
undetectable		 2w8yA-5ipyA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		4 / 4 SER A  13
GLY A  14
GLY A 314
GLY A 163
 FAD  A 502 (-2.8A)
None
FAD  A 502 ( 4.3A)
FAD  A 502 (-3.5A)
 0.90A 3bogB-5ipyA:
undetectable
3bogD-5ipyA:
undetectable		 3bogB-5ipyA:
undetectable
3bogD-5ipyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_A_LLTA261_1
(DEOXYCYTIDINE KINASE)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		5 / 10 LEU A 380
TYR A 376
GLN A  17
PHE A 311
LEU A 313
 None
 1.47A 3qeoA-5ipyA:
1.4		 3qeoA-5ipyA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		5 / 12 SER A 440
LEU A 445
VAL A 102
ALA A  95
HIS A 430
 None
 1.24A 3u9fD-5ipyA:
undetectable
3u9fE-5ipyA:
undetectable		 3u9fD-5ipyA:
17.47
3u9fE-5ipyA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		5 / 12 GLN A 318
HIS A 164
PRO A  12
ALA A  10
GLY A   9
 FAD  A 502 (-3.2A)
None
FAD  A 502 (-3.7A)
None
FAD  A 502 (-3.3A)
 1.31A 3v3oB-5ipyA:
11.5		 3v3oB-5ipyA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		4 / 5 VAL A 302
GLY A 301
TYR A 299
ASP A 352
 None
 1.30A 3w9tA-5ipyA:
undetectable		 3w9tA-5ipyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		4 / 5 VAL A 302
GLY A 301
TYR A 299
ASP A 352
 None
 1.31A 3w9tB-5ipyA:
undetectable		 3w9tB-5ipyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		4 / 5 VAL A 302
GLY A 301
TYR A 299
ASP A 352
 None
 1.30A 3w9tC-5ipyA:
undetectable		 3w9tC-5ipyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		4 / 5 VAL A 302
GLY A 301
TYR A 299
ASP A 352
 None
 1.30A 3w9tD-5ipyA:
undetectable		 3w9tD-5ipyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		4 / 5 VAL A 302
GLY A 301
TYR A 299
ASP A 352
 None
 1.31A 3w9tE-5ipyA:
undetectable		 3w9tE-5ipyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		4 / 5 VAL A 302
GLY A 301
TYR A 299
ASP A 352
 None
 1.31A 3w9tF-5ipyA:
undetectable		 3w9tF-5ipyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		4 / 5 VAL A 302
GLY A 301
TYR A 299
ASP A 352
 None
 1.32A 3w9tG-5ipyA:
undetectable		 3w9tG-5ipyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		4 / 7 SER A  65
TRP A  47
HIS A  63
SER A 166
 FAD  A 502 (-4.4A)
FAD  A 502 (-4.0A)
FAD  A 502 (-3.4A)
FAD  A 502 ( 4.5A)
 1.09A 4k7gB-5ipyA:
undetectable		 4k7gB-5ipyA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		3 / 3 ASP A 317
TRP A 401
SER A 206
 None
None
NAP  A 501 (-2.8A)
 0.95A 4lrhB-5ipyA:
undetectable		 4lrhB-5ipyA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		3 / 3 ASP A 317
TRP A 401
SER A 206
 None
None
NAP  A 501 (-2.8A)
 0.88A 4lrhF-5ipyA:
undetectable		 4lrhF-5ipyA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		4 / 4 TYR A 299
LYS A 300
GLU A 379
TYR A 376
 None
 1.40A 4w5rA-5ipyA:
0.0		 4w5rA-5ipyA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		4 / 5 TYR A 299
LYS A 300
GLU A 379
TYR A 376
 None
 1.42A 4z4hA-5ipyA:
undetectable		 4z4hA-5ipyA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		4 / 4 TYR A 299
LYS A 300
GLU A 379
TYR A 376
 None
 1.41A 4z4iA-5ipyA:
0.0		 4z4iA-5ipyA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		4 / 6 ASP A 334
TRP A 331
THR A 384
TYR A 386
 None
 1.46A 5b6iB-5ipyA:
2.6		 5b6iB-5ipyA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_1
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		4 / 4 ASP A 392
ALA A 382
SER A 388
PHE A 320
 None
 1.40A 6cm4A-5ipyA:
undetectable		 6cm4A-5ipyA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 5ipy FLAVIN-CONTAINING
MONOOXYGENASE
(Roseovarius
nubinhibens) 		5 / 12 ILE A   8
GLY A   9
GLY A  11
ALA A  16
VAL A 126
 None
FAD  A 502 (-3.3A)
FAD  A 502 (-3.4A)
None
FAD  A 502 (-4.0A)
 0.77A 6iftA-5ipyA:
2.9		 6iftA-5ipyA:
20.72