SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iq5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 5iq5 MACRO DOMAIN
(Mayaro
virus) 		5 / 11 ALA A  14
VAL A  37
ILE A  65
ILE A 106
VAL A  33
 None
 1.01A 2nnpB-5iq5A:
undetectable		 2nnpB-5iq5A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5iq5 MACRO DOMAIN
(Mayaro
virus) 		4 / 8 LEU A 128
LEU A 129
ALA A  93
ALA A 137
 None
 0.74A 2vcvP-5iq5A:
undetectable		 2vcvP-5iq5A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5iq5 MACRO DOMAIN
(Mayaro
virus) 		4 / 6 ILE A 141
ILE A 101
LEU A 125
MET A 132
 None
 0.93A 3adsA-5iq5A:
undetectable		 3adsA-5iq5A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5iq5 MACRO DOMAIN
(Mayaro
virus) 		5 / 9 ALA A  55
THR A  54
ALA A  88
ALA A  68
ALA A  94
 None
 1.11A 5l5zK-5iq5A:
undetectable
5l5zL-5iq5A:
undetectable		 5l5zK-5iq5A:
16.11
5l5zL-5iq5A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5iq5 MACRO DOMAIN
(Mayaro
virus) 		5 / 9 ALA A  55
THR A  54
ALA A  88
ALA A  68
ALA A  94
 None
 1.11A 5l5zY-5iq5A:
undetectable
5l5zZ-5iq5A:
undetectable		 5l5zY-5iq5A:
16.11
5l5zZ-5iq5A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 5iq5 MACRO DOMAIN
(Mayaro
virus) 		5 / 12 ALA A  14
VAL A  37
ILE A  65
ILE A 106
VAL A  33
 None
 0.94A 6dilA-5iq5A:
undetectable		 6dilA-5iq5A:
21.18