SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iq6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 12 ARG A 438
GLU A 486
ARG A 391
GLU A 397
TYR A 482
 None
 1.47A 1a4gA-5iq6A:
undetectable		 1a4gA-5iq6A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		4 / 8 VAL A 450
HIS A 441
CYH A 446
GLY A 447
 None
ZN  A1002 (-3.3A)
ZN  A1002 (-2.2A)
None
 1.01A 1ekjA-5iq6A:
undetectable
1ekjB-5iq6A:
undetectable		 1ekjA-5iq6A:
15.61
1ekjB-5iq6A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 3 PHE A 398
VAL A 425
TRP A 431
 None
 0.87A 2cc8A-5iq6A:
undetectable		 2cc8A-5iq6A:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 3 PHE A 398
VAL A 425
TRP A 431
 None
 0.89A 2ccbA-5iq6A:
undetectable		 2ccbA-5iq6A:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		4 / 5 TYR A 299
TYR A 304
ILE A 591
ARG A 581
 None
 1.30A 2du8J-5iq6A:
undetectable		 2du8J-5iq6A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 3 ASP A 544
ASP A 596
ASP A 683
 None
 0.76A 2igtA-5iq6A:
undetectable		 2igtA-5iq6A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 12 ALA A 866
VAL A 870
ALA A 782
THR A 328
LEU A 774
 None
 1.15A 2japA-5iq6A:
undetectable		 2japA-5iq6A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 12 ALA A 866
VAL A 870
ALA A 782
THR A 328
LEU A 774
 None
 1.15A 2japB-5iq6A:
undetectable		 2japB-5iq6A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 12 ALA A 866
VAL A 870
ALA A 782
THR A 328
LEU A 774
 None
 1.14A 2japC-5iq6A:
undetectable		 2japC-5iq6A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 12 ALA A 866
VAL A 870
ALA A 782
THR A 328
LEU A 774
 None
 1.14A 2japD-5iq6A:
undetectable		 2japD-5iq6A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 9 LEU A 724
ILE A 517
GLY A 510
PRO A 727
VAL A 726
 None
 1.17A 2r5qA-5iq6A:
undetectable		 2r5qA-5iq6A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 9 LEU A 724
ILE A 517
GLY A 510
PRO A 727
VAL A 726
 None
 1.17A 2r5qC-5iq6A:
undetectable		 2r5qC-5iq6A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 12 ILE A 735
ALA A 775
TYR A 766
LEU A 734
LEU A 839
 None
 0.99A 2rctA-5iq6A:
undetectable		 2rctA-5iq6A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 3 PHE A 398
VAL A 425
TRP A 431
 None
 0.87A 2vx9A-5iq6A:
undetectable		 2vx9A-5iq6A:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 3 ALA A 424
ARG A 471
LYS A 469
 None
 1.11A 3kp5B-5iq6A:
undetectable		 3kp5B-5iq6A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		6 / 9 ASP A 538
SER A 600
ASN A 609
GLY A 662
ASP A 663
ASP A 664
 None
 1.08A 3sfuA-5iq6A:
19.2		 3sfuA-5iq6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 9 ASP A 538
ASN A 609
GLY A 662
ASP A 663
ASP A 664
 None
 0.79A 3sfuB-5iq6A:
21.3		 3sfuB-5iq6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 11 ASP A 538
SER A 600
ASN A 609
GLY A 662
ASP A 663
 None
 1.16A 3sfuC-5iq6A:
19.6		 3sfuC-5iq6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 3 GLN A 351
PHE A 354
TYR A 299
 None
 0.87A 3ucjB-5iq6A:
undetectable		 3ucjB-5iq6A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 3 GLN A 351
PHE A 354
TYR A 299
 None
 0.90A 3ucjA-5iq6A:
undetectable		 3ucjA-5iq6A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 3 THR A 832
ASN A 835
GLU A 834
 None
 0.64A 3v4tA-5iq6A:
undetectable
3v4tC-5iq6A:
undetectable		 3v4tA-5iq6A:
23.51
3v4tC-5iq6A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 3 GLN A 861
THR A 865
ASN A 862
 None
 0.88A 3v4tE-5iq6A:
undetectable		 3v4tE-5iq6A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 12 MET A 273
TYR A 293
SER A 593
GLY A 277
ILE A 280
 None
 1.32A 3vwqA-5iq6A:
undetectable		 3vwqA-5iq6A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 12 ARG A 438
GLU A 486
ARG A 391
GLU A 397
TYR A 482
 None
 1.50A 4cpnA-5iq6A:
undetectable		 4cpnA-5iq6A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 3 ARG A 739
LYS A 329
LYS A 325
 None
 1.32A 4k50A-5iq6A:
8.0		 4k50A-5iq6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 3 ARG A 739
LYS A 329
LYS A 325
 None
 1.31A 4k50I-5iq6A:
8.2		 4k50I-5iq6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 12 ILE A 735
ALA A 775
TYR A 766
LEU A 734
LEU A 839
 None
 1.16A 4qynA-5iq6A:
undetectable		 4qynA-5iq6A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 12 ILE A 735
ALA A 775
TYR A 766
LEU A 734
LEU A 839
 None
 1.01A 4qzuC-5iq6A:
undetectable		 4qzuC-5iq6A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 11 ARG A 382
LEU A 380
GLU A 653
LEU A 655
LEU A 618
 None
 1.13A 4wg0H-5iq6A:
undetectable
4wg0I-5iq6A:
undetectable
4wg0J-5iq6A:
undetectable		 4wg0H-5iq6A:
2.09
4wg0I-5iq6A:
2.09
4wg0J-5iq6A:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 3 THR A 360
THR A 301
ARG A 594
 None
 1.02A 5wm2A-5iq6A:
2.7		 5wm2A-5iq6A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 3 GLN A 731
TRP A 331
VAL A 334
 None
 1.16A 6auuA-5iq6A:
undetectable		 6auuA-5iq6A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		4 / 8 ILE A 541
TRP A 537
ARG A 540
ASN A 613
 None
 1.22A 6hisA-5iq6A:
undetectable
6hisB-5iq6A:
undetectable		 6hisA-5iq6A:
10.16
6hisB-5iq6A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		4 / 8 ILE A 541
TRP A 537
ARG A 540
ASN A 613
 None
 1.21A 6hisB-5iq6A:
undetectable
6hisC-5iq6A:
undetectable		 6hisB-5iq6A:
10.16
6hisC-5iq6A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		4 / 8 ILE A 541
TRP A 537
ARG A 540
ASN A 613
 None
 1.21A 6hisC-5iq6A:
undetectable
6hisD-5iq6A:
undetectable		 6hisC-5iq6A:
10.16
6hisD-5iq6A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		4 / 8 ILE A 541
TRP A 537
ARG A 540
ASN A 613
 None
 1.22A 6hisD-5iq6A:
undetectable
6hisE-5iq6A:
undetectable		 6hisD-5iq6A:
10.16
6hisE-5iq6A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5iq6 RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		4 / 8 ASN A 613
ILE A 541
TRP A 537
ARG A 540
 None
 1.20A 6hisA-5iq6A:
undetectable
6hisE-5iq6A:
undetectable		 6hisA-5iq6A:
10.16
6hisE-5iq6A:
10.16