SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iqk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		5 / 10 LEU A 105
VAL A 173
VAL A 101
TRP A 195
LEU A 178
 None
 1.38A 1lw0A-5iqkA:
undetectable		 1lw0A-5iqkA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		5 / 11 LEU A 105
VAL A 173
VAL A 101
TRP A 195
LEU A 178
 None
 1.47A 1lwcA-5iqkA:
undetectable		 1lwcA-5iqkA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 7 TYR A 150
ASP A 137
ASP A 147
HIS A 186
 None
None
None
ZN  A 401 (-3.2A)
 1.45A 1t03A-5iqkA:
undetectable		 1t03A-5iqkA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 7 TYR A 150
ASP A 146
ASP A 147
HIS A 108
 None
None
None
ZN  A 401 (-3.2A)
 1.12A 1t03A-5iqkA:
undetectable		 1t03A-5iqkA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 7 TYR A 150
ASP A 146
ASP A 147
HIS A 186
 None
None
None
ZN  A 401 (-3.2A)
 1.34A 1t03A-5iqkA:
undetectable		 1t03A-5iqkA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 8 PHE A 222
ARG A 295
HIS A 110
LEU A 153
 None
None
ZN  A 401 (-3.1A)
None
 1.09A 1x8vA-5iqkA:
undetectable		 1x8vA-5iqkA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 8 ASP A  77
SER A 107
TYR A 284
HIS A 254
 None
None
None
ZN  A 402 (-3.2A)
 1.23A 2bteA-5iqkA:
undetectable		 2bteA-5iqkA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 8 ASP A  77
SER A 107
TYR A 284
HIS A 254
 None
None
None
ZN  A 402 (-3.2A)
 1.31A 2bteD-5iqkA:
undetectable		 2bteD-5iqkA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		5 / 10 LEU A 105
VAL A 173
VAL A 101
TRP A 195
LEU A 178
 None
 1.48A 2hnyA-5iqkA:
undetectable		 2hnyA-5iqkA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 5 TRP A 193
ALA A 130
LEU A 178
ALA A 165
 None
 1.35A 2jstA-5iqkA:
undetectable
2jstB-5iqkA:
undetectable		 2jstA-5iqkA:
15.57
2jstB-5iqkA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 7 GLN A 149
LEU A 153
LEU A  80
GLY A  79
 None
 0.60A 2qqcD-5iqkA:
undetectable
2qqcE-5iqkA:
undetectable		 2qqcD-5iqkA:
18.22
2qqcE-5iqkA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 8 ALA A 114
HIS A 108
GLY A 115
ILE A 111
 None
ZN  A 401 (-3.2A)
None
None
 0.89A 2zm9A-5iqkA:
undetectable		 2zm9A-5iqkA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_A_SPMA501_1
(SPERMINE SYNTHASE)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		5 / 11 TYR A 208
ASP A 112
ASP A 137
ASP A 147
GLN A 149
 None
ZN  A 402 (-2.4A)
None
None
None
 1.34A 3c6mA-5iqkA:
undetectable		 3c6mA-5iqkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_D_SPMD501_1
(SPERMINE SYNTHASE)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		5 / 10 TYR A 208
ASP A 112
ASP A 137
ASP A 147
GLN A 149
 None
ZN  A 402 (-2.4A)
None
None
None
 1.33A 3c6mD-5iqkA:
undetectable		 3c6mD-5iqkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		5 / 12 GLY A  78
ALA A 129
ALA A 130
LEU A 138
SER A  83
 None
 1.24A 3mteA-5iqkA:
undetectable		 3mteA-5iqkA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		5 / 10 LEU A 105
VAL A 173
VAL A 101
TRP A 195
LEU A 178
 None
 1.47A 3qipA-5iqkA:
undetectable		 3qipA-5iqkA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		5 / 10 HIS A 108
HIS A 110
ASP A 112
HIS A 186
HIS A 254
 ZN  A 401 (-3.2A)
ZN  A 401 (-3.1A)
ZN  A 402 (-2.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.2A)
 0.73A 4c1dB-5iqkA:
18.5		 4c1dB-5iqkA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		5 / 11 HIS A 108
HIS A 110
ASP A 112
HIS A 186
HIS A 254
 ZN  A 401 (-3.2A)
ZN  A 401 (-3.1A)
ZN  A 402 (-2.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.2A)
 0.74A 4c1fA-5iqkA:
17.7
4c1fB-5iqkA:
17.3		 4c1fA-5iqkA:
22.70
4c1fB-5iqkA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		5 / 9 HIS A 108
HIS A 110
ASP A 112
HIS A 186
HIS A 254
 ZN  A 401 (-3.2A)
ZN  A 401 (-3.1A)
ZN  A 402 (-2.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.2A)
 0.72A 4c1hA-5iqkA:
19.3		 4c1hA-5iqkA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		5 / 10 GLY A 115
ASP A 112
GLY A  79
HIS A 108
HIS A 254
 None
ZN  A 402 (-2.4A)
None
ZN  A 401 (-3.2A)
ZN  A 402 (-3.2A)
 1.15A 4c5nB-5iqkA:
undetectable		 4c5nB-5iqkA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 8 HIS A 110
ASP A 112
HIS A 186
HIS A 254
 ZN  A 401 (-3.1A)
ZN  A 402 (-2.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.2A)
 0.64A 4exsB-5iqkA:
17.6		 4exsB-5iqkA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 8 VAL A  37
HIS A 110
ASP A 112
HIS A 186
 None
ZN  A 401 (-3.1A)
ZN  A 402 (-2.4A)
ZN  A 401 (-3.2A)
 0.58A 4exsB-5iqkA:
17.6		 4exsB-5iqkA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 7 ASP A 112
ASP A 210
GLU A 256
ASP A  77
 ZN  A 402 (-2.4A)
None
None
None
 1.12A 4feuB-5iqkA:
undetectable		 4feuB-5iqkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 8 ASP A 112
ASP A 210
GLU A 256
ASP A  77
 ZN  A 402 (-2.4A)
None
None
None
 1.07A 4feuD-5iqkA:
undetectable		 4feuD-5iqkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 8 ASP A 112
ASP A 210
GLU A 256
ASP A  77
 ZN  A 402 (-2.4A)
None
None
None
 1.09A 4feuF-5iqkA:
undetectable		 4feuF-5iqkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 7 ASP A 112
ASP A 210
GLU A 256
ASP A  77
 ZN  A 402 (-2.4A)
None
None
None
 1.11A 4fevB-5iqkA:
undetectable		 4fevB-5iqkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 7 ASP A 112
ASP A 210
GLU A 256
ASP A  77
 ZN  A 402 (-2.4A)
None
None
None
 1.13A 4fevD-5iqkA:
undetectable		 4fevD-5iqkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 7 ASP A 112
ASP A 210
GLU A 256
ASP A  77
 ZN  A 402 (-2.4A)
None
None
None
 1.12A 4fevF-5iqkA:
undetectable		 4fevF-5iqkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 7 ASP A 112
ASP A 210
GLU A 256
ASP A  77
 ZN  A 402 (-2.4A)
None
None
None
 1.07A 4fewB-5iqkA:
undetectable		 4fewB-5iqkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 8 ASP A 112
ASP A 210
GLU A 256
ASP A  77
 ZN  A 402 (-2.4A)
None
None
None
 1.13A 4fewD-5iqkA:
undetectable		 4fewD-5iqkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 8 ASP A 112
ASP A 210
GLU A 256
ASP A  77
 ZN  A 402 (-2.4A)
None
None
None
 1.16A 4fewF-5iqkA:
undetectable		 4fewF-5iqkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 7 ASP A 112
ASP A 210
GLU A 256
ASP A  77
 ZN  A 402 (-2.4A)
None
None
None
 1.16A 4fexB-5iqkA:
undetectable		 4fexB-5iqkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 8 ASP A 112
ASP A 210
GLU A 256
ASP A  77
 ZN  A 402 (-2.4A)
None
None
None
 1.17A 4gkhB-5iqkA:
undetectable		 4gkhB-5iqkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 8 ASP A 112
ASP A 210
GLU A 256
ASP A  77
 ZN  A 402 (-2.4A)
None
None
None
 1.09A 4gkhD-5iqkA:
undetectable		 4gkhD-5iqkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 8 ASP A 112
ASP A 210
GLU A 256
ASP A  77
 ZN  A 402 (-2.4A)
None
None
None
 1.13A 4gkhF-5iqkA:
undetectable		 4gkhF-5iqkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 7 ASP A 112
ASP A 210
GLU A 256
ASP A  77
 ZN  A 402 (-2.4A)
None
None
None
 1.13A 4gkhG-5iqkA:
undetectable		 4gkhG-5iqkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 8 ASP A 112
ASP A 210
GLU A 256
ASP A  77
 ZN  A 402 (-2.4A)
None
None
None
 1.15A 4gkhC-5iqkA:
undetectable
4gkhK-5iqkA:
undetectable		 4gkhC-5iqkA:
20.98
4gkhK-5iqkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 8 ASP A 112
ASP A 210
GLU A 256
ASP A  77
 ZN  A 402 (-2.4A)
None
None
None
 1.14A 4gkiA-5iqkA:
undetectable		 4gkiA-5iqkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 8 ASP A 112
ASP A 210
GLU A 256
ASP A  77
 ZN  A 402 (-2.4A)
None
None
None
 1.19A 4gkiC-5iqkA:
undetectable		 4gkiC-5iqkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 8 ASP A 112
ASP A 210
GLU A 256
ASP A  77
 ZN  A 402 (-2.4A)
None
None
None
 1.14A 4gkiE-5iqkA:
undetectable
4gkiG-5iqkA:
undetectable		 4gkiE-5iqkA:
20.98
4gkiG-5iqkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		5 / 12 ASN A 106
HIS A 108
HIS A 186
HIS A 110
PRO A 255
 None
ZN  A 401 (-3.2A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.1A)
None
 1.24A 4yhaE-5iqkA:
undetectable		 4yhaE-5iqkA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 8 HIS A 110
ASP A 112
HIS A 186
HIS A 254
 ZN  A 401 (-3.1A)
ZN  A 402 (-2.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.2A)
 0.66A 5a5zA-5iqkA:
17.6		 5a5zA-5iqkA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_1
(MEDI2452 HEAVY CHAIN
MEDI2452 LIGHT CHAIN)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		5 / 11 THR A 183
TYR A 208
PRO A 255
ASP A  77
LEU A 117
 None
 1.49A 5albH-5iqkA:
undetectable		 5albH-5iqkA:
22.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		9 / 11 HIS A 108
HIS A 110
ASP A 112
HIS A 113
HIS A 186
SER A 211
VAL A 215
HIS A 254
GLU A 256
 ZN  A 401 (-3.2A)
ZN  A 401 (-3.1A)
ZN  A 402 (-2.4A)
ZN  A 402 (-3.1A)
ZN  A 401 (-3.2A)
ZN  A 402 ( 4.1A)
None
ZN  A 402 (-3.2A)
None
 0.38A 5ayaA-5iqkA:
43.0		 5ayaA-5iqkA:
44.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		5 / 11 LEU A 105
VAL A 173
VAL A 101
TRP A 195
LEU A 178
 None
 1.45A 5hbmA-5iqkA:
undetectable		 5hbmA-5iqkA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 7 ASP A 147
GLY A 190
GLY A 185
HIS A 186
 None
None
None
ZN  A 401 (-3.2A)
 1.02A 5n9xA-5iqkA:
undetectable		 5n9xA-5iqkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 9 LYS A  86
ILE A  87
ILE A  91
LEU A  94
 None
 0.70A 5vkqB-5iqkA:
undetectable
5vkqC-5iqkA:
undetectable		 5vkqB-5iqkA:
10.45
5vkqC-5iqkA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 8 HIS A 110
ASP A 112
HIS A 108
HIS A 254
 ZN  A 401 (-3.1A)
ZN  A 402 (-2.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.2A)
 0.98A 5zj8A-5iqkA:
17.7		 5zj8A-5iqkA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 5iqk BETA-LACTAMASE RM3
(uncultured
bacterium) 		4 / 8 HIS A 110
ASP A 112
HIS A 186
HIS A 254
 ZN  A 401 (-3.1A)
ZN  A 402 (-2.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.2A)
 0.69A 5zj8A-5iqkA:
17.7		 5zj8A-5iqkA:
25.43