SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iqp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 5iqp 14-3-3 PROTEIN THETA
(Homo
sapiens) 		5 / 11 ARG A  56
LEU A  90
LEU A  98
GLY A 123
ASP A 124
 SO4  A 301 (-3.0A)
None
None
None
None
 1.31A 3sfuC-5iqpA:
undetectable		 3sfuC-5iqpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 5iqp 14-3-3 PROTEIN THETA
(Homo
sapiens) 		3 / 3 ARG A  91
ASP A  81
GLN A  77
 None
 0.86A 4azsA-5iqpA:
undetectable		 4azsA-5iqpA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 5iqp 14-3-3 PROTEIN THETA
(Homo
sapiens) 		4 / 8 PHE A 153
THR A 194
TYR A 178
PHE A 177
 None
 1.06A 4drjB-5iqpA:
3.6		 4drjB-5iqpA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 5iqp 14-3-3 PROTEIN THETA
(Homo
sapiens) 		6 / 12 ASP A 154
SER A 156
THR A 190
THR A 194
ALA A 192
ALA A 195
 None
 1.46A 4u15A-5iqpA:
3.0		 4u15A-5iqpA:
19.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5iqp 14-3-3 PROTEIN THETA
(Homo
sapiens) 		4 / 5 PHE A 196
ILE A 200
MET A 218
GLN A 219
 None
 1.05A 5jm4A-5iqpA:
33.1		 5jm4A-5iqpA:
81.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5iqp 14-3-3 PROTEIN THETA
(Homo
sapiens) 		4 / 5 PHE A 196
MET A 218
GLN A 219
ARG A 222
 None
 1.48A 5jm4A-5iqpA:
33.1		 5jm4A-5iqpA:
81.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M35_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5iqp 14-3-3 PROTEIN THETA
(Homo
sapiens) 		4 / 5 PHE A 196
THR A 215
MET A 218
ARG A 222
 None
 1.06A 5m35A-5iqpA:
33.7		 5m35A-5iqpA:
80.87