SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ir2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9J_B_CLWB907_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 5ir2 CELLULASE
(Parabacteroides
johnsonii) 		4 / 5 VAL A  83
TYR A  97
MET A  95
GLU A  94
 None
 1.45A 1m9jB-5ir2A:
undetectable		 1m9jB-5ir2A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 5ir2 CELLULASE
(Parabacteroides
johnsonii) 		3 / 3 ALA A  80
VAL A 111
TRP A 113
 None
 0.96A 1tkqA-5ir2A:
undetectable		 1tkqA-5ir2A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 5ir2 CELLULASE
(Parabacteroides
johnsonii) 		5 / 12 ILE A 194
LEU A 203
GLY A 197
VAL A  49
ALA A  48
 None
 1.09A 1tlsA-5ir2A:
undetectable		 1tlsA-5ir2A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 5ir2 CELLULASE
(Parabacteroides
johnsonii) 		5 / 12 ILE A 194
LEU A 203
GLY A 197
VAL A  49
ALA A  48
 None
 1.16A 1tlsB-5ir2A:
undetectable		 1tlsB-5ir2A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 5ir2 CELLULASE
(Parabacteroides
johnsonii) 		5 / 12 ILE A 194
LEU A 203
GLY A 197
VAL A  49
ALA A  48
 None
 1.13A 1tsnA-5ir2A:
undetectable		 1tsnA-5ir2A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 5ir2 CELLULASE
(Parabacteroides
johnsonii) 		5 / 12 ILE A 194
LEU A 203
GLY A 197
VAL A  49
ALA A  48
 None
 1.20A 4foxD-5ir2A:
undetectable		 4foxD-5ir2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 5ir2 CELLULASE
(Parabacteroides
johnsonii) 		5 / 12 ILE A 194
LEU A 203
GLY A 197
VAL A  49
ALA A  48
 None
 1.18A 4fqsA-5ir2A:
undetectable		 4fqsA-5ir2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 5ir2 CELLULASE
(Parabacteroides
johnsonii) 		5 / 12 ILE A 194
LEU A 203
GLY A 197
VAL A  49
ALA A  48
 None
 1.18A 4fqsB-5ir2A:
undetectable		 4fqsB-5ir2A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5ir2 CELLULASE
(Parabacteroides
johnsonii) 		4 / 8 HIS A 109
ASP A  34
ASP A 193
ILE A 194
 None
 0.77A 4k0bA-5ir2A:
undetectable		 4k0bA-5ir2A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5ir2 CELLULASE
(Parabacteroides
johnsonii) 		4 / 8 HIS A 109
ASP A  34
ASP A 193
ILE A 194
 None
 0.76A 4l7iA-5ir2A:
undetectable		 4l7iA-5ir2A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5ir2 CELLULASE
(Parabacteroides
johnsonii) 		4 / 8 GLY A 197
ILE A 194
LEU A  38
GLU A  42
 None
 0.84A 4mwzB-5ir2A:
undetectable		 4mwzB-5ir2A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 5ir2 CELLULASE
(Parabacteroides
johnsonii) 		3 / 3 ARG A 117
ASP A 143
TYR A 163
 None
None
NHE  A 301 ( 4.1A)
 0.91A 4yo9B-5ir2A:
undetectable		 4yo9B-5ir2A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 5ir2 CELLULASE
(Parabacteroides
johnsonii) 		5 / 12 LEU A 196
GLY A 197
TYR A  73
PHE A  39
TYR A  41
 None
 1.36A 5czyA-5ir2A:
undetectable		 5czyA-5ir2A:
19.22