SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ir6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 200
VAL A 360
TRP A 205
 None
 0.78A 1c4dC-5ir6A:
undetectable
1c4dD-5ir6A:
undetectable		 1c4dC-5ir6A:
4.04
1c4dD-5ir6A:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
(Geobacillus
stearothermophil
us) 		3 / 3 TRP A 205
ALA A 200
VAL A 360
 None
 0.72A 1c4dC-5ir6A:
undetectable
1c4dD-5ir6A:
undetectable		 1c4dC-5ir6A:
4.04
1c4dD-5ir6A:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 365
MET A 224
MET A  34
LEU A 359
 None
 0.92A 1kt3A-5ir6A:
undetectable		 1kt3A-5ir6A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
BD-TYPE QUINOL
OXIDASE SUBUNIT II
(Geobacillus
stearothermophil
us) 		4 / 7 PHE B  67
GLU A 101
LEU A  98
THR A  73
 None
HEB  A 502 (-3.0A)
None
HEB  A 502 (-4.6A)
 0.96A 1rmtB-5ir6B:
undetectable		 1rmtB-5ir6B:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A 197
ALA A 366
LEU A 365
ILE A 328
 None
 1.05A 1sbrA-5ir6A:
undetectable
1sbrB-5ir6A:
undetectable		 1sbrA-5ir6A:
19.65
1sbrB-5ir6A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 370
ALA A  25
LEU A  18
THR A 147
ARG A 381
 HEB  A 501 (-4.0A)
HEB  A 502 (-3.7A)
HDD  A 503 (-3.1A)
HDD  A 503 (-4.0A)
HDD  A 503 (-3.5A)
 1.09A 1tdrA-5ir6A:
undetectable		 1tdrA-5ir6A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
(Geobacillus
stearothermophil
us) 		3 / 3 ALA A 200
VAL A 360
TRP A 205
 None
 0.87A 1tkqB-5ir6A:
undetectable		 1tkqB-5ir6A:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT II
(Geobacillus
stearothermophil
us) 		4 / 7 MET B 237
VAL B 239
SER B 241
MET B 210
 None
 1.07A 1wrlA-5ir6B:
undetectable
1wrlB-5ir6B:
0.6		 1wrlA-5ir6B:
11.14
1wrlB-5ir6B:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT II
(Geobacillus
stearothermophil
us) 		5 / 11 LEU B 157
VAL B 143
GLY B 149
HIS B 223
LYS B 156
 None
 1.29A 1y4lB-5ir6B:
1.2		 1y4lB-5ir6B:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
BD-TYPE QUINOL
OXIDASE SUBUNIT II
(Geobacillus
stearothermophil
us;
Geobacillus
stearothermophil
us) 		5 / 11 VAL A  70
GLY B 100
ARG B  99
THR B 123
ILE B 127
 None
 1.38A 2f9wA-5ir6A:
undetectable
2f9wB-5ir6A:
undetectable		 2f9wA-5ir6A:
22.32
2f9wB-5ir6A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT II
(Geobacillus
stearothermophil
us) 		3 / 3 ASN B 114
LEU B 117
HIS B 106
 None
 0.84A 2q6fB-5ir6B:
undetectable		 2q6fB-5ir6B:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WB9_A_CYSA301_0
(GLUTATHIONE
TRANSFERASE SIGMA
CLASS)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT II
(Geobacillus
stearothermophil
us) 		4 / 5 GLY B 100
ARG B  99
TYR B 120
TYR B 102
 None
 1.50A 2wb9A-5ir6B:
1.9		 2wb9A-5ir6B:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT II
(Geobacillus
stearothermophil
us) 		4 / 7 ILE B 316
LEU B 319
VAL B  21
GLY B  17
 None
 0.77A 2wd9A-5ir6B:
undetectable		 2wd9A-5ir6B:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
(Geobacillus
stearothermophil
us) 		4 / 4 GLY A  28
VAL A  65
GLY A  72
THR A  73
 HEB  A 502 ( 4.0A)
HEB  A 502 (-3.4A)
HEB  A 502 (-3.4A)
HEB  A 502 (-4.6A)
 0.92A 3ib2A-5ir6A:
undetectable		 3ib2A-5ir6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
(Geobacillus
stearothermophil
us) 		3 / 3 LYS A 252
ILE A 146
PHE A 145
 HEB  A 501 (-3.3A)
HDD  A 503 ( 2.9A)
None
 0.99A 3j7zS-5ir6A:
0.5
3j7za-5ir6A:
undetectable		 3j7zS-5ir6A:
13.85
3j7za-5ir6A:
4.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
(Geobacillus
stearothermophil
us) 		5 / 12 LEU A 332
ALA A 200
GLY A 362
LEU A 359
ALA A 219
 None
 1.35A 3ou7C-5ir6A:
undetectable		 3ou7C-5ir6A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 217
LEU A 207
THR A 223
 None
 0.82A 3oxcA-5ir6A:
undetectable		 3oxcA-5ir6A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
PUTATIVE MEMBRANE
PROTEIN
(Geobacillus
sp.
PA-3;
Geobacillus
stearothermophil
us) 		4 / 8 HIS C 792
MET A  48
ILE A  43
ARG A  44
 None
 1.13A 3sfeB-5ir6C:
undetectable
3sfeC-5ir6C:
undetectable		 3sfeB-5ir6C:
8.96
3sfeC-5ir6C:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
(Geobacillus
stearothermophil
us) 		5 / 12 TYR A 389
ALA A  90
GLU A 101
VAL A 149
ILE A 146
 None
None
HEB  A 502 (-3.0A)
HDD  A 503 ( 4.9A)
HDD  A 503 ( 2.9A)
 1.14A 4aztA-5ir6A:
undetectable		 4aztA-5ir6A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT II
(Geobacillus
stearothermophil
us) 		5 / 12 LEU B 284
TYR B  80
GLY B 294
ASP B 293
GLY B  72
 None
 0.97A 4blvA-5ir6B:
undetectable		 4blvA-5ir6B:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
BD-TYPE QUINOL
OXIDASE SUBUNIT II
(Geobacillus
stearothermophil
us) 		4 / 4 GLY A  76
VAL B  68
PHE A 152
ILE A  94
 HEB  A 502 (-3.4A)
None
None
None
 1.03A 4xv2B-5ir6A:
3.0		 4xv2B-5ir6A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
(Geobacillus
stearothermophil
us) 		3 / 3 THR A 303
THR A 262
PHE A 260
 None
 0.53A 5cxvA-5ir6A:
2.7		 5cxvA-5ir6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
(Geobacillus
stearothermophil
us) 		4 / 5 VAL A 135
VAL A  31
GLY A  30
PHE A  61
 None
 1.02A 5d4nA-5ir6A:
undetectable
5d4nC-5ir6A:
undetectable		 5d4nA-5ir6A:
14.93
5d4nC-5ir6A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
BD-TYPE QUINOL
OXIDASE SUBUNIT II
(Geobacillus
stearothermophil
us) 		5 / 10 VAL B  21
ILE B  20
LEU B 266
PHE B 262
ILE A 110
 None
 1.23A 5hw8C-5ir6B:
undetectable
5hw8H-5ir6B:
undetectable		 5hw8C-5ir6B:
15.50
5hw8H-5ir6B:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
(Geobacillus
stearothermophil
us) 		5 / 10 VAL A 324
THR A 327
ILE A 328
LEU A 365
PHE A 331
 None
 0.97A 5mxbA-5ir6A:
undetectable		 5mxbA-5ir6A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
(Geobacillus
stearothermophil
us) 		5 / 12 PHE A 322
ALA A 294
GLY A 242
GLY A 238
LEU A 270
 None
None
HEB  A 501 (-3.4A)
HEB  A 501 (-3.5A)
None
 1.15A 5ul4A-5ir6A:
undetectable		 5ul4A-5ir6A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 203
LEU A 199
VAL A  65
VAL A 135
ALA A  38
 None
None
HEB  A 502 (-3.4A)
None
None
 1.05A 6djzC-5ir6A:
undetectable		 6djzC-5ir6A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
(Geobacillus
stearothermophil
us) 		4 / 5 VAL A 135
LEU A 132
HIS A 128
THR A  58
 None
 1.26A 6dyoA-5ir6A:
undetectable		 6dyoA-5ir6A:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I
(Geobacillus
stearothermophil
us) 		4 / 6 MET A 405
LEU A 406
THR A 397
LEU A   8
 None
 1.21A 6mvxA-5ir6A:
undetectable
6mvxB-5ir6A:
2.9
6mvxC-5ir6A:
2.3		 6mvxA-5ir6A:
22.59
6mvxB-5ir6A:
22.59
6mvxC-5ir6A:
22.59