SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5irb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 5irb RTX-ADHESIN
(Marinomonas
primoryensis) 		5 / 11 THR A 342
GLY A 319
VAL A 369
ASP A 329
VAL A 331
 None
 1.17A 1akdA-5irbA:
undetectable		 1akdA-5irbA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 5irb RTX-ADHESIN
(Marinomonas
primoryensis) 		5 / 11 THR A 446
GLY A 422
VAL A 473
ASP A 433
VAL A 435
 None
 1.20A 1akdA-5irbA:
undetectable		 1akdA-5irbA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5irb RTX-ADHESIN
(Marinomonas
primoryensis) 		5 / 11 GLY A 215
ALA A 265
ILE A 193
GLY A 225
THR A 238
 None
 1.14A 1gtfQ-5irbA:
undetectable
1gtfR-5irbA:
1.9		 1gtfQ-5irbA:
13.40
1gtfR-5irbA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 5irb RTX-ADHESIN
(Marinomonas
primoryensis) 		4 / 6 TRP A 350
VAL A 321
ILE A 295
LEU A 339
 None
 1.15A 1j96A-5irbA:
undetectable		 1j96A-5irbA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 5irb RTX-ADHESIN
(Marinomonas
primoryensis) 		3 / 3 ALA A 402
VAL A 400
TRP A 454
 None
 0.61A 1micA-5irbA:
undetectable
1micB-5irbA:
undetectable		 1micA-5irbA:
7.87
1micB-5irbA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 5irb RTX-ADHESIN
(Marinomonas
primoryensis) 		4 / 8 SER A 476
THR A 482
ASP A 484
GLU A 438
 None
 0.91A 1mxgA-5irbA:
undetectable		 1mxgA-5irbA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5irb RTX-ADHESIN
(Marinomonas
primoryensis) 		4 / 5 ASP A 484
VAL A 483
SER A 475
ASP A 470
 None
 1.41A 1n2xB-5irbA:
undetectable		 1n2xB-5irbA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 5irb RTX-ADHESIN
(Marinomonas
primoryensis) 		5 / 11 THR A 446
GLY A 422
VAL A 473
ASP A 433
VAL A 435
 None
 1.18A 1phgA-5irbA:
undetectable		 1phgA-5irbA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 5irb RTX-ADHESIN
(Marinomonas
primoryensis) 		4 / 4 THR A 197
GLY A 376
ASP A 373
ALA A 204
 CA  A 601 (-3.2A)
None
None
None
 1.10A 1sg9A-5irbA:
undetectable		 1sg9A-5irbA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 5irb RTX-ADHESIN
(Marinomonas
primoryensis) 		4 / 4 THR A 301
GLY A 480
ASP A 477
ALA A 308
 CA  A 604 (-3.0A)
None
CA  A 602 (-3.2A)
None
 1.11A 1sg9A-5irbA:
undetectable		 1sg9A-5irbA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5irb RTX-ADHESIN
(Marinomonas
primoryensis) 		5 / 11 GLY A 215
ALA A 265
ILE A 193
GLY A 225
THR A 238
 None
 1.15A 1utdS-5irbA:
1.9
1utdT-5irbA:
1.9		 1utdS-5irbA:
13.40
1utdT-5irbA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5irb RTX-ADHESIN
(Marinomonas
primoryensis) 		5 / 10 GLY A 215
ALA A 265
ILE A 193
GLY A 225
THR A 238
 None
 1.14A 1utdU-5irbA:
2.0
1utdV-5irbA:
1.9		 1utdU-5irbA:
13.40
1utdV-5irbA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5irb RTX-ADHESIN
(Marinomonas
primoryensis) 		5 / 11 GLY A 225
THR A 238
GLY A 215
ALA A 265
ILE A 193
 None
 1.12A 1utdL-5irbA:
1.9
1utdV-5irbA:
1.9		 1utdL-5irbA:
13.40
1utdV-5irbA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5irb RTX-ADHESIN
(Marinomonas
primoryensis) 		5 / 11 THR A 342
GLY A 319
VAL A 369
ASP A 329
VAL A 331
 None
 1.20A 2a1nA-5irbA:
undetectable		 2a1nA-5irbA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 5irb RTX-ADHESIN
(Marinomonas
primoryensis) 		5 / 12 GLY A 487
ALA A 471
VAL A 420
VAL A 448
VAL A 435
 None
 1.00A 3ucbB-5irbA:
undetectable		 3ucbB-5irbA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5irb RTX-ADHESIN
(Marinomonas
primoryensis) 		4 / 7 ASP A 329
GLY A 381
THR A 382
ILE A 295
 None
 0.96A 4acaC-5irbA:
undetectable		 4acaC-5irbA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 5irb RTX-ADHESIN
(Marinomonas
primoryensis) 		5 / 10 THR A 446
GLY A 422
VAL A 473
ASP A 433
VAL A 435
 None
 1.14A 4c9nB-5irbA:
undetectable		 4c9nB-5irbA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 5irb RTX-ADHESIN
(Marinomonas
primoryensis) 		5 / 10 THR A 446
GLY A 422
VAL A 473
ASP A 433
VAL A 435
 None
 1.22A 4c9pB-5irbA:
undetectable		 4c9pB-5irbA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 5irb RTX-ADHESIN
(Marinomonas
primoryensis) 		4 / 7 THR A 446
VAL A 473
ASP A 433
VAL A 435
 None
 0.90A 4cp4A-5irbA:
undetectable		 4cp4A-5irbA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WZM_A_ACTA503_0
(RNA DEPENDENT RNA
POLYMERASE)		 5irb RTX-ADHESIN
(Marinomonas
primoryensis) 		4 / 4 ASP A 390
ASP A 477
ASP A 394
ALA A 479
 CA  A 602 (-2.2A)
CA  A 602 (-3.2A)
None
None
 1.48A 4wzmA-5irbA:
undetectable		 4wzmA-5irbA:
21.56