SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5irc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 5irc RHO
GTPASE-ACTIVATING
PROTEIN 35
(Rattus
norvegicus) 		4 / 7 PHE A1299
ASN A1245
HIS A1303
VAL A1254
 None
 1.27A 1wu8A-5ircA:
undetectable
1wu8C-5ircA:
undetectable		 1wu8A-5ircA:
18.75
1wu8C-5ircA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 5irc RHO
GTPASE-ACTIVATING
PROTEIN 35
(Rattus
norvegicus) 		3 / 3 ASP A1302
PHE A1299
LEU A1295
 None
 0.56A 2zi9A-5ircA:
undetectable		 2zi9A-5ircA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5irc RHO
GTPASE-ACTIVATING
PROTEIN 35
(Rattus
norvegicus) 		4 / 7 ALA A1274
TYR A1271
ARG A1267
ALA A1308
 None
 1.04A 3twpB-5ircA:
2.1		 3twpB-5ircA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5irc RHO
GTPASE-ACTIVATING
PROTEIN 35
(Rattus
norvegicus) 		4 / 7 ALA A1274
TYR A1271
ARG A1267
ALA A1308
 None
 1.01A 3twpC-5ircA:
undetectable		 3twpC-5ircA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5irc RHO
GTPASE-ACTIVATING
PROTEIN 35
(Rattus
norvegicus) 		3 / 3 GLY A1287
THR A1316
ASN A1288
 None
 0.70A 3v4tD-5ircA:
undetectable		 3v4tD-5ircA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5irc RHO
GTPASE-ACTIVATING
PROTEIN 35
(Rattus
norvegicus) 		4 / 8 SER A1383
GLU A1426
ILE A1429
ASN A1386
 None
 1.09A 4d33A-5ircA:
undetectable		 4d33A-5ircA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5irc RHO
GTPASE-ACTIVATING
PROTEIN 35
(Rattus
norvegicus) 		4 / 7 SER A1383
GLU A1426
ILE A1429
ASN A1386
 None
 1.10A 4d33B-5ircA:
undetectable		 4d33B-5ircA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5irc RHO
GTPASE-ACTIVATING
PROTEIN 35
(Rattus
norvegicus) 		4 / 8 SER A1383
GLU A1426
ILE A1429
ASN A1386
 None
 1.01A 4d39A-5ircA:
undetectable		 4d39A-5ircA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5irc RHO
GTPASE-ACTIVATING
PROTEIN 35
(Rattus
norvegicus) 		4 / 7 SER A1383
GLU A1426
ILE A1429
ASN A1386
 None
 1.00A 4d39B-5ircA:
undetectable		 4d39B-5ircA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 5irc RHO
GTPASE-ACTIVATING
PROTEIN 35
(Rattus
norvegicus) 		3 / 3 PRO A1433
ASN A1380
HIS A1384
 CSX  A1432 ( 2.6A)
CSX  A1432 ( 4.0A)
None
 0.56A 4ma3H-5ircA:
undetectable
4ma3L-5ircA:
undetectable		 4ma3H-5ircA:
20.83
4ma3L-5ircA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 5irc RHO
GTPASE-ACTIVATING
PROTEIN 35
(Rattus
norvegicus) 		4 / 5 HIS A1378
ILE A1272
PHE A1400
ALA A1318
 None
 1.20A 5msdA-5ircA:
undetectable		 5msdA-5ircA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 5irc RHO
GTPASE-ACTIVATING
PROTEIN 35
(Rattus
norvegicus) 		4 / 6 VAL A1375
ILE A1269
GLU A1273
ARG A1381
 None
 0.82A 5z3jA-5ircA:
undetectable		 5z3jA-5ircA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 5irc RHO
GTPASE-ACTIVATING
PROTEIN 35
(Rattus
norvegicus) 		4 / 5 PHE A1372
VAL A1255
PRO A1365
VAL A1333
 None
 1.25A 6ekzA-5ircA:
undetectable		 6ekzA-5ircA:
17.65