SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iri'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5iri SERINE/THREONINE-PRO
TEIN KINASE BRSK1

(Mus
musculus)
4 / 8 ALA A 646
ASP A 623
ILE A 624
ILE A 667
None
0.78A 1p7lD-5iriA:
undetectable
1p7lD-5iriA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5iri SERINE/THREONINE-PRO
TEIN KINASE BRSK1

(Mus
musculus)
4 / 8 ALA A 646
ASP A 623
ILE A 624
ILE A 667
None
0.78A 1p7lC-5iriA:
undetectable
1p7lC-5iriA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5iri SERINE/THREONINE-PRO
TEIN KINASE BRSK1

(Mus
musculus)
4 / 8 ALA A 646
ASP A 623
ILE A 624
ILE A 667
None
0.78A 1rg9B-5iriA:
undetectable
1rg9B-5iriA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5iri SERINE/THREONINE-PRO
TEIN KINASE BRSK1

(Mus
musculus)
4 / 8 ALA A 646
ASP A 623
ILE A 624
ILE A 667
None
0.79A 1rg9A-5iriA:
undetectable
1rg9A-5iriA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5iri SERINE/THREONINE-PRO
TEIN KINASE BRSK1

(Mus
musculus)
4 / 8 ALA A 646
ASP A 623
ILE A 624
ILE A 667
None
0.78A 1rg9D-5iriA:
undetectable
1rg9D-5iriA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
5iri SERINE/THREONINE-PRO
TEIN KINASE BRSK1

(Mus
musculus)
4 / 8 ALA A 646
ASP A 623
ILE A 624
ILE A 667
None
0.77A 1rg9C-5iriA:
undetectable
1rg9C-5iriA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)
5iri SERINE/THREONINE-PRO
TEIN KINASE BRSK1

(Mus
musculus)
5 / 12 LEU A 634
ILE A 709
PHE A 702
ILE A 667
PHE A 628
None
1.07A 2ygoA-5iriA:
undetectable
2ygoA-5iriA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5iri SERINE/THREONINE-PRO
TEIN KINASE BRSK1

(Mus
musculus)
4 / 8 ALA A 646
ASP A 623
ILE A 624
ILE A 667
None
0.84A 4ndnB-5iriA:
undetectable
4ndnB-5iriA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5iri SERINE/THREONINE-PRO
TEIN KINASE BRSK1

(Mus
musculus)
4 / 8 ALA A 646
ASP A 623
ILE A 624
ILE A 667
None
0.82A 4ndnD-5iriA:
undetectable
4ndnD-5iriA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
5iri SERINE/THREONINE-PRO
TEIN KINASE BRSK1

(Mus
musculus)
4 / 7 VAL A 705
PHE A 628
HIS A 636
GLU A 647
None
1.23A 5ad9A-5iriA:
undetectable
5ad9B-5iriA:
undetectable
5ad9A-5iriA:
14.35
5ad9B-5iriA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)
5iri SERINE/THREONINE-PRO
TEIN KINASE BRSK1

(Mus
musculus)
4 / 8 ALA A 646
ASP A 623
ILE A 624
ILE A 667
None
0.84A 5t8sA-5iriA:
undetectable
5t8sA-5iriA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5iri SERINE/THREONINE-PRO
TEIN KINASE BRSK1

(Mus
musculus)
4 / 5 ILE A 624
PHE A 628
ARG A 645
THR A 693
None
1.03A 5z84N-5iriA:
undetectable
5z84W-5iriA:
undetectable
5z84N-5iriA:
12.23
5z84W-5iriA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
5iri SERINE/THREONINE-PRO
TEIN KINASE BRSK1

(Mus
musculus)
4 / 7 ALA A 646
ASP A 623
ILE A 624
ILE A 667
None
0.90A 6fbnA-5iriA:
undetectable
6fbnA-5iriA:
14.96