SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5irp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		5 / 10 GLY A 294
SER A 296
LEU A 299
THR A 361
LEU A 359
 None
 1.20A 1a8uA-5irpA:
undetectable		 1a8uA-5irpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		5 / 10 GLY A 294
SER A 296
LEU A 299
THR A 361
LEU A 359
 None
 1.24A 1a8uB-5irpA:
undetectable		 1a8uB-5irpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		5 / 11 SER A  47
TYR A  43
GLU A  69
GLY A  70
LEU A  73
 None
UAH  A 402 (-4.7A)
None
None
None
 1.40A 1i9jH-5irpA:
undetectable
1i9jL-5irpA:
undetectable		 1i9jH-5irpA:
21.34
1i9jL-5irpA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		4 / 6 VAL A 314
VAL A 355
ILE A 341
ARG A 317
 None
None
None
CL  A 416 (-4.5A)
 1.15A 1iepA-5irpA:
undetectable		 1iepA-5irpA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		3 / 3 ALA A 157
VAL A 152
TRP A 163
 None
 0.85A 1kqeA-5irpA:
undetectable
1kqeE-5irpA:
undetectable		 1kqeA-5irpA:
2.11
1kqeE-5irpA:
2.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		3 / 3 ALA A 157
VAL A 152
TRP A 163
 None
 0.86A 1kqeB-5irpA:
undetectable
1kqeD-5irpA:
undetectable		 1kqeB-5irpA:
2.11
1kqeD-5irpA:
2.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		3 / 3 TRP A 163
ALA A 157
VAL A 152
 None
 0.87A 1kqeB-5irpA:
undetectable
1kqeD-5irpA:
undetectable		 1kqeB-5irpA:
2.11
1kqeD-5irpA:
2.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		3 / 3 TRP A 163
ALA A 157
VAL A 152
 None
 0.87A 1kqeA-5irpA:
undetectable
1kqeE-5irpA:
undetectable		 1kqeA-5irpA:
2.11
1kqeE-5irpA:
2.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		4 / 8 PHE A 216
ALA A 211
ILE A 239
ASN A 209
 None
TRS  A 403 ( 4.7A)
None
TRS  A 403 (-4.6A)
 1.14A 1pnlA-5irpA:
undetectable
1pnlB-5irpA:
undetectable		 1pnlA-5irpA:
19.13
1pnlB-5irpA:
23.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		4 / 8 LYS A  39
TYR A  43
ARG A 139
TYR A 364
 UAH  A 402 ( 4.0A)
UAH  A 402 (-4.7A)
UAH  A 402 (-3.4A)
TRS  A 403 ( 3.3A)
 0.24A 1xqlA-5irpA:
50.2
1xqlB-5irpA:
49.9		 1xqlA-5irpA:
42.36
1xqlB-5irpA:
42.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		4 / 8 LYS A  39
TYR A  43
ARG A 139
TYR A 364
 UAH  A 402 ( 4.0A)
UAH  A 402 (-4.7A)
UAH  A 402 (-3.4A)
TRS  A 403 ( 3.3A)
 0.32A 1xqlA-5irpA:
50.2
1xqlB-5irpA:
49.9		 1xqlA-5irpA:
42.36
1xqlB-5irpA:
42.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		5 / 10 GLY A  77
ALA A  76
GLY A  70
ILE A  82
ILE A  48
 None
 0.94A 2aquA-5irpA:
undetectable		 2aquA-5irpA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		5 / 11 GLY A  77
ALA A  76
GLY A  70
ILE A  82
ILE A  48
 None
 0.89A 2aquB-5irpA:
undetectable		 2aquB-5irpA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		5 / 12 GLY A  77
ALA A  76
GLY A  70
ILE A  82
ILE A  48
 None
 0.87A 2b60A-5irpA:
undetectable		 2b60A-5irpA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		4 / 6 LEU A  83
TRP A 110
MET A 111
LEU A 155
 None
 1.47A 2oz7A-5irpA:
undetectable		 2oz7A-5irpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		5 / 12 GLY A  77
ALA A  76
GLY A  70
ILE A  82
ILE A  48
 None
 0.89A 2q64A-5irpA:
undetectable		 2q64A-5irpA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		5 / 12 GLY A  77
ALA A  76
GLY A  70
ILE A  82
ILE A  48
 None
 0.98A 2qakB-5irpA:
undetectable		 2qakB-5irpA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		5 / 12 GLY A  77
ALA A  76
GLY A  70
ILE A  82
ILE A  48
 None
 0.93A 2qhcB-5irpA:
undetectable		 2qhcB-5irpA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		5 / 12 GLY A  77
ALA A  76
GLY A  70
ILE A  82
ILE A  48
 None
 0.87A 2rkfA-5irpA:
undetectable		 2rkfA-5irpA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		5 / 12 GLY A  77
ALA A  76
GLY A  70
ILE A  82
ILE A  48
 None
 1.01A 3d1zB-5irpA:
undetectable		 3d1zB-5irpA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		4 / 5 GLN A 184
THR A 181
THR A 210
HIS A 169
 None
None
UAH  A 402 (-3.5A)
UAH  A 402 (-3.6A)
 1.14A 3g1uC-5irpA:
undetectable		 3g1uC-5irpA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		5 / 10 SER A 300
LEU A 253
ILE A 289
SER A 296
GLY A 290
 None
 1.34A 3ijxB-5irpA:
undetectable
3ijxD-5irpA:
undetectable		 3ijxB-5irpA:
21.64
3ijxD-5irpA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		5 / 10 ILE A 289
SER A 296
GLY A 290
SER A 300
LEU A 253
 None
 1.29A 3ik6B-5irpA:
undetectable
3ik6E-5irpA:
undetectable		 3ik6B-5irpA:
21.64
3ik6E-5irpA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		5 / 10 SER A 300
LEU A 253
ILE A 289
SER A 296
GLY A 290
 None
 1.34A 3iluB-5irpA:
undetectable
3iluE-5irpA:
undetectable		 3iluB-5irpA:
21.64
3iluE-5irpA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		5 / 11 ILE A 289
SER A 296
GLY A 290
SER A 300
LEU A 253
 None
 1.32A 3iluB-5irpA:
undetectable
3iluE-5irpA:
undetectable		 3iluB-5irpA:
21.64
3iluE-5irpA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		5 / 9 GLY A  77
ALA A  76
GLY A  70
ILE A  82
ILE A  48
 None
 0.91A 3nujB-5irpA:
undetectable		 3nujB-5irpA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		5 / 9 GLY A  77
ALA A  76
GLY A  70
ILE A  82
ILE A  48
 None
 0.92A 3nuoB-5irpA:
undetectable		 3nuoB-5irpA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		3 / 3 ILE A 374
VAL A   8
ARG A   6
 None
 0.67A 3p73A-5irpA:
undetectable		 3p73A-5irpA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		5 / 10 GLY A  77
ALA A  76
GLY A  70
ILE A  82
ILE A  48
 None
 0.94A 3s43B-5irpA:
undetectable		 3s43B-5irpA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		5 / 11 GLY A  77
ALA A  76
GLY A  70
ILE A  82
ILE A  48
 None
 0.87A 4hlaB-5irpA:
undetectable		 4hlaB-5irpA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		4 / 5 ILE A 284
ARG A 264
GLU A 282
VAL A 312
 None
None
MG  A 414 (-3.4A)
None
 1.07A 4nkxC-5irpA:
undetectable		 4nkxC-5irpA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		4 / 5 ILE A 284
ARG A 264
GLU A 282
VAL A 312
 None
None
MG  A 414 (-3.4A)
None
 1.07A 4nkxD-5irpA:
undetectable		 4nkxD-5irpA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		4 / 8 ILE A 228
VAL A  12
LEU A 251
ILE A  10
 UAH  A 402 (-3.7A)
None
None
None
 0.74A 4r38A-5irpA:
undetectable		 4r38A-5irpA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		3 / 3 LYS A  18
HIS A  57
HIS A  53
 None
 1.32A 5oexA-5irpA:
undetectable		 5oexA-5irpA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		3 / 3 LYS A  18
HIS A  57
HIS A  53
 None
 1.40A 5oexB-5irpA:
undetectable		 5oexB-5irpA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		3 / 3 LYS A  18
HIS A  57
HIS A  53
 None
 1.38A 5oexC-5irpA:
undetectable		 5oexC-5irpA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		3 / 3 LYS A  18
HIS A  57
HIS A  53
 None
 1.32A 5oexD-5irpA:
undetectable		 5oexD-5irpA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5irp ALANINE RACEMASE 2
(Bacillus
subtilis) 		4 / 6 VAL A  67
LEU A 103
LEU A 127
LEU A  90
 None
 0.81A 6f6sA-5irpA:
undetectable
6f6sB-5irpA:
undetectable		 6f6sA-5irpA:
15.74
6f6sB-5irpA:
11.34