SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iry'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		5 / 12 LEU A   9
LEU A  50
ARG A  64
GLN A  22
LEU A  76
 None
 1.44A 1nhzA-5iryA:
undetectable		 1nhzA-5iryA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 7 ASP A 363
GLY A 391
ILE A 386
THR A 426
 CA  A 613 ( 4.5A)
None
None
MAN  A 618 (-2.0A)
 0.79A 1t7iB-5iryA:
undetectable		 1t7iB-5iryA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 7 ASP A 363
GLY A 391
ILE A 386
THR A 426
 CA  A 613 ( 4.5A)
None
None
MAN  A 618 (-2.0A)
 0.80A 1t7jB-5iryA:
undetectable		 1t7jB-5iryA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 8 GLU A 402
ASP A 400
TYR A 436
HIS A 439
 CA  A 609 ( 2.1A)
CA  A 609 (-3.0A)
None
None
 0.91A 1v7zA-5iryA:
undetectable		 1v7zA-5iryA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 8 GLU A 402
ASP A 400
TYR A 436
HIS A 439
 CA  A 609 ( 2.1A)
CA  A 609 (-3.0A)
None
None
 0.93A 1v7zB-5iryA:
undetectable		 1v7zB-5iryA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 8 GLU A 402
ASP A 400
TYR A 436
HIS A 439
 CA  A 609 ( 2.1A)
CA  A 609 (-3.0A)
None
None
 0.94A 1v7zC-5iryA:
undetectable		 1v7zC-5iryA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 8 GLU A 402
ASP A 400
TYR A 436
HIS A 439
 CA  A 609 ( 2.1A)
CA  A 609 (-3.0A)
None
None
 0.91A 1v7zD-5iryA:
undetectable		 1v7zD-5iryA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 8 GLU A 402
ASP A 400
TYR A 436
HIS A 439
 CA  A 609 ( 2.1A)
CA  A 609 (-3.0A)
None
None
 0.90A 1v7zE-5iryA:
undetectable		 1v7zE-5iryA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 8 GLU A 402
ASP A 400
TYR A 436
HIS A 439
 CA  A 609 ( 2.1A)
CA  A 609 (-3.0A)
None
None
 0.93A 1v7zF-5iryA:
undetectable		 1v7zF-5iryA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		5 / 9 ALA A 361
GLY A 427
LEU A 372
ILE A 386
ALA A 417
 None
 0.96A 2z0yA-5iryA:
undetectable		 2z0yA-5iryA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		5 / 9 ALA A 361
GLY A 427
LEU A 372
ILE A 386
ALA A 417
 None
 0.91A 2z0yB-5iryA:
undetectable		 2z0yB-5iryA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		5 / 11 MET A 188
ILE A 149
LEU A 186
ILE A 169
THR A 172
 None
 1.40A 3a50B-5iryA:
undetectable		 3a50B-5iryA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 8 GLU A 402
ASP A 400
TYR A 436
HIS A 439
 CA  A 609 ( 2.1A)
CA  A 609 (-3.0A)
None
None
 0.91A 3a6jA-5iryA:
undetectable		 3a6jA-5iryA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 7 GLU A 402
ASP A 400
TYR A 436
HIS A 439
 CA  A 609 ( 2.1A)
CA  A 609 (-3.0A)
None
None
 0.94A 3a6jB-5iryA:
undetectable		 3a6jB-5iryA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 8 GLU A 402
ASP A 400
TYR A 436
HIS A 439
 CA  A 609 ( 2.1A)
CA  A 609 (-3.0A)
None
None
 0.95A 3a6jC-5iryA:
undetectable		 3a6jC-5iryA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 8 GLU A 402
ASP A 400
TYR A 436
HIS A 439
 CA  A 609 ( 2.1A)
CA  A 609 (-3.0A)
None
None
 0.94A 3a6jE-5iryA:
undetectable		 3a6jE-5iryA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 7 GLY A 167
LYS A 129
TYR A 147
ARG A 144
 None
 1.25A 3arrA-5iryA:
2.1		 3arrA-5iryA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 7 GLY A 167
LYS A 129
TYR A 147
ARG A 144
 None
 1.24A 3aruA-5iryA:
3.0		 3aruA-5iryA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2W_A_ELVA397_1
(INTEGRASE)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 5 ASP A 103
ASP A  67
TYR A  71
GLU A  11
 CA  A 614 ( 2.9A)
CA  A 605 (-2.2A)
None
CA  A 614 ( 3.1A)
 1.29A 3l2wA-5iryA:
undetectable		 3l2wA-5iryA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 7 ASP A 103
ASP A  67
TYR A  71
GLU A  11
 CA  A 614 ( 2.9A)
CA  A 605 (-2.2A)
None
CA  A 614 ( 3.1A)
 1.23A 3s3oA-5iryA:
undetectable		 3s3oA-5iryA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		5 / 12 VAL A 398
GLU A 402
HIS A 439
ASP A 465
ASP A 348
 None
CA  A 609 ( 2.1A)
None
CA  A 610 ( 3.8A)
CA  A 609 ( 3.1A)
 1.49A 3ximA-5iryA:
undetectable		 3ximA-5iryA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1226_0
(THAUMATIN-LIKE
PROTEIN)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 5 GLU A 402
TYR A 436
ASP A 438
ASN A 469
 CA  A 609 ( 2.1A)
None
CA  A 609 ( 2.7A)
None
 1.47A 3zs3A-5iryA:
0.0		 3zs3A-5iryA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		3 / 3 HIS A 142
GLU A  69
ASN A  12
 None
CA  A 614 ( 2.9A)
CA  A 605 ( 3.9A)
 0.93A 4bupB-5iryA:
undetectable		 4bupB-5iryA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 7 ASP A 348
ASP A 516
ASP A 465
GLU A 402
 CA  A 609 ( 3.1A)
CA  A 611 (-3.0A)
CA  A 610 ( 3.8A)
CA  A 609 ( 2.1A)
 0.91A 4feuB-5iryA:
undetectable		 4feuB-5iryA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 8 ASP A 348
ASP A 516
ASP A 465
GLU A 402
 CA  A 609 ( 3.1A)
CA  A 611 (-3.0A)
CA  A 610 ( 3.8A)
CA  A 609 ( 2.1A)
 0.95A 4feuD-5iryA:
undetectable		 4feuD-5iryA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 8 ASP A 348
ASP A 516
ASP A 465
GLU A 402
 CA  A 609 ( 3.1A)
CA  A 611 (-3.0A)
CA  A 610 ( 3.8A)
CA  A 609 ( 2.1A)
 0.96A 4feuF-5iryA:
undetectable		 4feuF-5iryA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 7 ASP A 348
ASP A 516
ASP A 465
GLU A 402
 CA  A 609 ( 3.1A)
CA  A 611 (-3.0A)
CA  A 610 ( 3.8A)
CA  A 609 ( 2.1A)
 0.97A 4fevB-5iryA:
undetectable		 4fevB-5iryA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 7 ASP A 348
ASP A 516
ASP A 465
GLU A 402
 CA  A 609 ( 3.1A)
CA  A 611 (-3.0A)
CA  A 610 ( 3.8A)
CA  A 609 ( 2.1A)
 0.96A 4fevD-5iryA:
undetectable		 4fevD-5iryA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 7 ASP A 348
ASP A 516
ASP A 465
GLU A 402
 CA  A 609 ( 3.1A)
CA  A 611 (-3.0A)
CA  A 610 ( 3.8A)
CA  A 609 ( 2.1A)
 0.95A 4fevF-5iryA:
undetectable		 4fevF-5iryA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 7 ASP A 348
ASP A 516
ASP A 465
GLU A 402
 CA  A 609 ( 3.1A)
CA  A 611 (-3.0A)
CA  A 610 ( 3.8A)
CA  A 609 ( 2.1A)
 0.97A 4fewB-5iryA:
undetectable		 4fewB-5iryA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 8 ASP A 348
ASP A 516
ASP A 465
GLU A 402
 CA  A 609 ( 3.1A)
CA  A 611 (-3.0A)
CA  A 610 ( 3.8A)
CA  A 609 ( 2.1A)
 0.96A 4fewD-5iryA:
undetectable		 4fewD-5iryA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 8 ASP A 348
ASP A 516
ASP A 465
GLU A 402
 CA  A 609 ( 3.1A)
CA  A 611 (-3.0A)
CA  A 610 ( 3.8A)
CA  A 609 ( 2.1A)
 0.92A 4fewF-5iryA:
undetectable		 4fewF-5iryA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 7 ASP A 348
ASP A 516
ASP A 465
GLU A 402
 CA  A 609 ( 3.1A)
CA  A 611 (-3.0A)
CA  A 610 ( 3.8A)
CA  A 609 ( 2.1A)
 0.96A 4fexB-5iryA:
undetectable		 4fexB-5iryA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 8 ASP A 348
ASP A 516
ASP A 465
GLU A 402
 CA  A 609 ( 3.1A)
CA  A 611 (-3.0A)
CA  A 610 ( 3.8A)
CA  A 609 ( 2.1A)
 0.99A 4gkhB-5iryA:
undetectable		 4gkhB-5iryA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 8 ASP A 348
ASP A 516
ASP A 465
GLU A 402
 CA  A 609 ( 3.1A)
CA  A 611 (-3.0A)
CA  A 610 ( 3.8A)
CA  A 609 ( 2.1A)
 0.98A 4gkhD-5iryA:
undetectable		 4gkhD-5iryA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 8 ASP A 348
ASP A 516
ASP A 465
GLU A 402
 CA  A 609 ( 3.1A)
CA  A 611 (-3.0A)
CA  A 610 ( 3.8A)
CA  A 609 ( 2.1A)
 0.97A 4gkhF-5iryA:
undetectable		 4gkhF-5iryA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 7 ASP A 348
ASP A 516
ASP A 465
GLU A 402
 CA  A 609 ( 3.1A)
CA  A 611 (-3.0A)
CA  A 610 ( 3.8A)
CA  A 609 ( 2.1A)
 0.94A 4gkhG-5iryA:
undetectable		 4gkhG-5iryA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 6 ASP A 348
ASP A 516
ASP A 465
GLU A 402
 CA  A 609 ( 3.1A)
CA  A 611 (-3.0A)
CA  A 610 ( 3.8A)
CA  A 609 ( 2.1A)
 1.00A 4gkhJ-5iryA:
undetectable		 4gkhJ-5iryA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 8 ASP A 348
ASP A 516
ASP A 465
GLU A 402
 CA  A 609 ( 3.1A)
CA  A 611 (-3.0A)
CA  A 610 ( 3.8A)
CA  A 609 ( 2.1A)
 0.95A 4gkhC-5iryA:
undetectable
4gkhK-5iryA:
undetectable		 4gkhC-5iryA:
19.60
4gkhK-5iryA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 8 ASP A 348
ASP A 516
ASP A 465
GLU A 402
 CA  A 609 ( 3.1A)
CA  A 611 (-3.0A)
CA  A 610 ( 3.8A)
CA  A 609 ( 2.1A)
 0.95A 4gkiA-5iryA:
undetectable		 4gkiA-5iryA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 8 ASP A 348
ASP A 516
ASP A 465
GLU A 402
 CA  A 609 ( 3.1A)
CA  A 611 (-3.0A)
CA  A 610 ( 3.8A)
CA  A 609 ( 2.1A)
 0.93A 4gkiC-5iryA:
undetectable		 4gkiC-5iryA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 8 ASP A 348
ASP A 516
ASP A 465
GLU A 402
 CA  A 609 ( 3.1A)
CA  A 611 (-3.0A)
CA  A 610 ( 3.8A)
CA  A 609 ( 2.1A)
 0.93A 4gkiE-5iryA:
undetectable
4gkiG-5iryA:
undetectable		 4gkiE-5iryA:
19.60
4gkiG-5iryA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 8 GLY A 301
GLN A 299
TYR A 225
PHE A 220
 None
 0.88A 4wryA-5iryA:
undetectable		 4wryA-5iryA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 8 GLY A 301
GLN A 299
TYR A 225
PHE A 220
 None
 0.85A 4wrzA-5iryA:
undetectable		 4wrzA-5iryA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 7 SER A 254
ASP A 245
PRO A 218
ASN A 278
 None
CA  A 607 (-2.1A)
None
None
 1.21A 5l1fC-5iryA:
undetectable		 5l1fC-5iryA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		3 / 3 HIS A 142
GLU A  69
ASN A  12
 None
CA  A 614 ( 2.9A)
CA  A 605 ( 3.9A)
 0.89A 5wbvA-5iryA:
undetectable		 5wbvA-5iryA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		3 / 3 HIS A 253
GLU A 179
ASN A 120
 None
CA  A 616 ( 2.6A)
CA  A 615 (-2.2A)
 0.93A 5wbvA-5iryA:
undetectable		 5wbvA-5iryA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		3 / 3 HIS A 142
GLU A  69
ASN A  12
 None
CA  A 614 ( 2.9A)
CA  A 605 ( 3.9A)
 0.89A 5wbvB-5iryA:
undetectable		 5wbvB-5iryA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		3 / 3 HIS A 253
GLU A 179
ASN A 120
 None
CA  A 616 ( 2.6A)
CA  A 615 (-2.2A)
 0.94A 5wbvB-5iryA:
undetectable		 5wbvB-5iryA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 5iry DESMOCOLLIN-1
(Homo
sapiens) 		4 / 7 HIS A 518
ASN A 437
GLU A 468
GLY A 466
 None
CA  A 611 (-3.2A)
None
None
 0.87A 6n7fA-5iryA:
undetectable		 6n7fA-5iryA:
8.76