SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iso'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		7 / 12 LEU A  22
ALA A  43
VAL A  96
GLU A 100
ASN A 144
LEU A 146
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-3.3A)
STU  A 601 (-4.0A)
STU  A 601 (-3.4A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.77A 1fmoE-5isoA:
31.3		 1fmoE-5isoA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		8 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
VAL A  96
ASN A 144
LEU A 146
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.0A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.60A 1fmoE-5isoA:
31.3		 1fmoE-5isoA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		4 / 7 THR A 172
GLY A 187
LEU A 189
TYR A 190
 None
 0.98A 1gtiD-5isoA:
undetectable		 1gtiD-5isoA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		6 / 9 LEU A  22
GLY A  23
VAL A  30
ALA A  43
TYR A  95
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
 0.57A 1muoA-5isoA:
10.9		 1muoA-5isoA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		4 / 7 ASN A 144
HIS A 137
PHE A 158
ILE A 123
 STU  A 601 (-4.3A)
None
None
None
 1.34A 1tdnA-5isoA:
undetectable		 1tdnA-5isoA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		5 / 12 ALA A 257
ILE A 262
ALA A 242
LEU A 208
PHE A 120
 None
 1.05A 1uduB-5isoA:
undetectable		 1uduB-5isoA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		6 / 9 LEU A  22
VAL A  30
ALA A  43
MET A  93
GLY A  99
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
STU  A 601 ( 4.0A)
STU  A 601 (-4.5A)
 0.97A 1xbbA-5isoA:
24.8		 1xbbA-5isoA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		6 / 12 ALA A  43
GLY A  99
ASP A 103
LEU A 146
ASP A 157
PHE A 158
 STU  A 601 (-3.3A)
STU  A 601 ( 4.0A)
None
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
None
 1.13A 1xkkA-5isoA:
23.1		 1xkkA-5isoA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		7 / 12 VAL A  30
LYS A  45
VAL A  96
ASN A 144
LEU A 146
ALA A 156
ASP A 157
 STU  A 601 (-4.8A)
STU  A 601 ( 4.4A)
STU  A 601 (-4.0A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
STU  A 601 (-3.5A)
 0.66A 2eufB-5isoA:
28.5		 2eufB-5isoA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		6 / 11 GLY A  23
GLY A  25
VAL A  30
ALA A  43
MET A  93
TYR A  95
 STU  A 601 (-3.4A)
STU  A 601 (-3.7A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
 0.46A 2evaA-5isoA:
24.2		 2evaA-5isoA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		6 / 11 GLY A  23
GLY A  25
VAL A  30
ALA A  43
TYR A  95
LEU A 146
 STU  A 601 (-3.4A)
STU  A 601 (-3.7A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
 0.62A 2evaA-5isoA:
24.2		 2evaA-5isoA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		9 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
VAL A  96
ASP A 139
LYS A 141
ASN A 144
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.0A)
None
None
STU  A 601 (-4.3A)
STU  A 601 (-3.5A)
 0.73A 2fumA-5isoA:
28.7		 2fumA-5isoA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		10 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
MET A  93
TYR A  95
VAL A  96
LYS A 141
ASN A 144
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-4.0A)
None
STU  A 601 (-4.3A)
STU  A 601 (-3.5A)
 0.77A 2fumB-5isoA:
28.5		 2fumB-5isoA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		8 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
MET A  93
TYR A  95
VAL A  96
ASN A 144
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-4.0A)
STU  A 601 (-4.3A)
 0.57A 2fumC-5isoA:
26.3		 2fumC-5isoA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		7 / 12 LEU A  22
GLY A  23
GLY A  25
VAL A  30
MET A  93
LYS A 141
ASN A 144
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-3.7A)
STU  A 601 (-4.8A)
STU  A 601 ( 3.9A)
None
STU  A 601 (-4.3A)
 0.91A 2fumD-5isoA:
26.4		 2fumD-5isoA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		7 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
LYS A 141
ASN A 144
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
STU  A 601 (-4.3A)
STU  A 601 (-3.5A)
 0.89A 2fumD-5isoA:
26.4		 2fumD-5isoA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		7 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
MET A  93
LYS A 141
ASN A 144
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
None
STU  A 601 (-4.3A)
 0.65A 2fumD-5isoA:
26.4		 2fumD-5isoA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		4 / 5 SER A 410
ASP A 414
PRO A 412
SER A 408
 None
 1.36A 2hdnA-5isoA:
undetectable
2hdnB-5isoA:
undetectable
2hdnD-5isoA:
undetectable		 2hdnA-5isoA:
4.53
2hdnB-5isoA:
20.33
2hdnD-5isoA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		4 / 5 SER A 408
SER A 410
ASP A 414
PRO A 412
 None
 1.35A 2hdnB-5isoA:
undetectable
2hdnC-5isoA:
undetectable
2hdnD-5isoA:
undetectable		 2hdnB-5isoA:
20.33
2hdnC-5isoA:
4.53
2hdnD-5isoA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		5 / 7 TYR A 129
HIS A  75
PRO A  74
TYR A 283
TYR A 275
 None
 1.23A 2oldA-5isoA:
undetectable
2oldB-5isoA:
undetectable		 2oldA-5isoA:
18.56
2oldB-5isoA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		4 / 7 HIS A  75
PRO A  74
TYR A 283
TYR A 275
 None
 0.98A 2ombC-5isoA:
undetectable
2ombD-5isoA:
undetectable		 2ombC-5isoA:
18.56
2ombD-5isoA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		4 / 7 TYR A 129
HIS A  75
TYR A 283
TYR A 275
 None
 1.30A 2ombC-5isoA:
undetectable
2ombD-5isoA:
undetectable		 2ombC-5isoA:
18.56
2ombD-5isoA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		4 / 7 TYR A 283
TYR A 129
HIS A  75
PRO A  74
 None
 1.15A 2ombC-5isoA:
undetectable
2ombD-5isoA:
undetectable		 2ombC-5isoA:
18.56
2ombD-5isoA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		4 / 8 TYR A 190
SER A 176
ILE A 185
SER A 199
 None
 1.03A 2xz5B-5isoA:
undetectable
2xz5E-5isoA:
undetectable		 2xz5B-5isoA:
18.71
2xz5E-5isoA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		5 / 12 LEU A 147
LEU A 207
HIS A  75
LEU A 276
TYR A 275
 None
 1.45A 3adsA-5isoA:
undetectable		 3adsA-5isoA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		4 / 6 LEU A  22
VAL A  30
LYS A  45
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 ( 4.4A)
STU  A 601 (-4.5A)
 0.70A 3cs9D-5isoA:
21.9		 3cs9D-5isoA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		9 / 12 LEU A  22
GLY A  23
GLY A  25
GLY A  28
VAL A  30
ALA A  43
LYS A  45
MET A  93
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-3.7A)
992  A 602 ( 3.8A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.5A)
 0.81A 3eygA-5isoA:
25.6		 3eygA-5isoA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		10 / 12 LEU A  22
GLY A  23
GLY A  25
GLY A  28
VAL A  30
ALA A  43
MET A  93
ASN A 144
LEU A 146
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-3.7A)
992  A 602 ( 3.8A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.82A 3eygA-5isoA:
25.6		 3eygA-5isoA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		9 / 12 LEU A  22
GLY A  23
GLY A  25
GLY A  28
VAL A  30
ALA A  43
LYS A  45
MET A  93
TYR A  95
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-3.7A)
992  A 602 ( 3.8A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
 0.73A 3fupA-5isoA:
26.1		 3fupA-5isoA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		9 / 12 LEU A  22
GLY A  23
GLY A  25
GLY A  28
VAL A  30
ALA A  43
MET A  93
TYR A  95
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-3.7A)
992  A 602 ( 3.8A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-3.5A)
 0.79A 3fupA-5isoA:
26.1		 3fupA-5isoA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		9 / 12 LEU A  22
GLY A  23
GLY A  28
VAL A  30
ALA A  43
LYS A  45
MET A  93
TYR A  95
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
992  A 602 ( 3.8A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
 0.78A 3fupA-5isoA:
26.1		 3fupA-5isoA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		9 / 12 LEU A  22
GLY A  23
GLY A  28
VAL A  30
ALA A  43
MET A  93
TYR A  95
LEU A 146
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
992  A 602 ( 3.8A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.74A 3fupA-5isoA:
26.1		 3fupA-5isoA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		7 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
LYS A  45
MET A  93
TYR A  95
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
 0.54A 3fupB-5isoA:
25.8		 3fupB-5isoA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		7 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
TYR A  95
LEU A 146
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.49A 3fupB-5isoA:
25.8		 3fupB-5isoA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		6 / 11 LEU A  22
VAL A  30
ALA A  43
TYR A  95
GLY A  99
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 ( 4.0A)
STU  A 601 (-4.5A)
 0.38A 3g0eA-5isoA:
21.7		 3g0eA-5isoA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		6 / 11 LEU A  22
VAL A  30
ALA A  43
TYR A  95
GLY A  99
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 ( 4.0A)
STU  A 601 (-4.5A)
 0.31A 3g0fA-5isoA:
22.5		 3g0fA-5isoA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		6 / 10 LEU A  22
VAL A  30
ALA A  43
TYR A  95
GLY A  99
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 ( 4.0A)
STU  A 601 (-4.5A)
 0.40A 3g0fB-5isoA:
22.8		 3g0fB-5isoA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		9 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
LYS A  45
MET A  93
TYR A  95
LEU A 146
ALA A 156
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.86A 3lxkA-5isoA:
26.3		 3lxkA-5isoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		9 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
MET A  93
TYR A  95
LEU A 146
ALA A 156
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
STU  A 601 (-3.5A)
 0.76A 3lxkA-5isoA:
26.3		 3lxkA-5isoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		7 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
LYS A  45
ILE A  77
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.5A)
 0.63A 3lxnA-5isoA:
26.4		 3lxnA-5isoA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		7 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
LYS A  45
ILE A  77
VAL A  96
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.0A)
 0.67A 3lxnA-5isoA:
26.4		 3lxnA-5isoA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		7 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
LYS A  45
TYR A  95
VAL A  96
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 (-4.3A)
STU  A 601 (-4.0A)
 0.62A 3lxnA-5isoA:
26.4		 3lxnA-5isoA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		7 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
TYR A  95
LEU A 146
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.48A 3lxnA-5isoA:
26.4		 3lxnA-5isoA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
LEU A  68
ILE A  77
TYR A  95
HIS A 137
ALA A 156
 STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
None
STU  A 601 (-3.5A)
 1.08A 3rgfA-5isoA:
5.6		 3rgfA-5isoA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		4 / 7 LEU A 455
GLN A 456
PHE A 469
LEU A 546
 None
 0.93A 3x2qC-5isoA:
undetectable
3x2qJ-5isoA:
undetectable		 3x2qC-5isoA:
16.49
3x2qJ-5isoA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		5 / 9 LEU A  22
ILE A  76
MET A  91
TYR A  95
ILE A 155
 STU  A 601 (-4.1A)
None
None
STU  A 601 (-4.3A)
None
 0.71A 3zosB-5isoA:
22.6		 3zosB-5isoA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		4 / 5 VAL A  30
ILE A  76
TYR A  95
ILE A 155
 STU  A 601 (-4.8A)
None
STU  A 601 (-4.3A)
None
 0.70A 4c8bA-5isoA:
23.4		 4c8bA-5isoA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		6 / 10 LEU A  22
GLY A  23
VAL A  30
ALA A  43
TYR A  95
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
 0.53A 4ckjA-5isoA:
25.5		 4ckjA-5isoA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		3 / 3 TYR A 129
HIS A 133
ARG A 132
 None
 0.96A 4e7bC-5isoA:
undetectable		 4e7bC-5isoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		9 / 12 VAL A  30
ALA A  43
ILE A  77
ASP A 103
ASP A 139
LYS A 141
ASN A 144
LEU A 146
ASP A 157
 STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.3A)
None
None
None
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.69A 4i41A-5isoA:
29.7		 4i41A-5isoA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		7 / 12 GLY A  23
VAL A  30
ALA A  43
LEU A  79
GLY A  99
GLU A 100
LEU A 146
 STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
None
STU  A 601 ( 4.0A)
STU  A 601 (-3.4A)
STU  A 601 (-4.5A)
 0.63A 4ifgA-5isoA:
25.6		 4ifgA-5isoA:
29.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		5 / 6 LEU A  22
GLY A  23
VAL A  30
ALA A  43
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.5A)
 0.32A 4o0wA-5isoA:
30.4		 4o0wA-5isoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		6 / 8 GLY A  25
VAL A  30
ALA A  43
ASN A 144
LEU A 146
ASP A 157
 STU  A 601 (-3.7A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.62A 4ogrA-5isoA:
28.0		 4ogrA-5isoA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		6 / 9 GLY A  25
VAL A  30
ALA A  43
ASN A 144
LEU A 146
ASP A 157
 STU  A 601 (-3.7A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.57A 4ogrI-5isoA:
27.7		 4ogrI-5isoA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		7 / 12 LEU A  22
GLY A  23
GLY A  28
VAL A  30
ALA A  43
LEU A 146
ALA A 156
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
992  A 602 ( 3.8A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.49A 4otiA-5isoA:
25.2		 4otiA-5isoA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		7 / 12 LEU A  22
GLY A  23
VAL A  30
ALA A  43
LYS A  45
LEU A 146
ALA A 156
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.30A 4otiA-5isoA:
25.2		 4otiA-5isoA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		6 / 12 GLY A  23
VAL A  30
ALA A  43
MET A  93
TYR A  95
LEU A 146
 STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
 0.74A 4qmzA-5isoA:
29.2		 4qmzA-5isoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		5 / 10 ALA A  43
LYS A  45
ILE A  77
VAL A  96
LEU A 146
 STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.0A)
STU  A 601 (-4.5A)
 0.95A 4rz7A-5isoA:
11.3		 4rz7A-5isoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		9 / 12 LEU A  22
VAL A  30
ALA A  43
LYS A  45
GLY A  99
ASN A 144
LEU A 146
ALA A 156
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 ( 4.0A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
STU  A 601 (-3.5A)
 0.78A 4twpA-5isoA:
25.2		 4twpA-5isoA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		9 / 12 LEU A  22
VAL A  30
ALA A  43
LYS A  45
GLY A  99
ASN A 144
LEU A 146
ALA A 156
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 ( 4.0A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
STU  A 601 (-3.5A)
 0.87A 4twpB-5isoA:
25.6		 4twpB-5isoA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		6 / 10 LEU A  22
VAL A  30
ILE A  76
TYR A  95
ARG A 138
ILE A 155
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
None
STU  A 601 (-4.3A)
None
None
 0.80A 4u0iA-5isoA:
22.3		 4u0iA-5isoA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		9 / 11 LEU A  22
VAL A  30
ALA A  43
TYR A  95
GLY A  99
ASN A 144
LEU A 146
ALA A 156
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 ( 4.0A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
STU  A 601 (-3.5A)
 0.95A 4u5jA-5isoA:
25.1		 4u5jA-5isoA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		7 / 9 LEU A  22
VAL A  30
ILE A  77
TYR A  95
ARG A 138
LEU A 146
ILE A 155
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
None
STU  A 601 (-4.5A)
None
 1.02A 4v01A-5isoA:
22.6		 4v01A-5isoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		7 / 9 LEU A  22
VAL A  30
LYS A  45
ILE A  77
TYR A  95
ARG A 138
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 ( 4.4A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
None
STU  A 601 (-4.5A)
 1.21A 4v01A-5isoA:
22.6		 4v01A-5isoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		6 / 9 LEU A  22
VAL A  30
ILE A  77
TYR A  95
LEU A 146
ILE A 155
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
None
 0.73A 4v01B-5isoA:
22.9		 4v01B-5isoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		6 / 9 LEU A  22
VAL A  30
LYS A  45
ILE A  77
TYR A  95
ILE A 155
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 ( 4.4A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
None
 0.80A 4v01B-5isoA:
22.9		 4v01B-5isoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		5 / 8 ILE A  77
TYR A  95
ARG A 138
LEU A 146
ILE A 155
 STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
None
STU  A 601 (-4.5A)
None
 1.09A 4v04A-5isoA:
22.4		 4v04A-5isoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		4 / 8 LYS A  45
ILE A  77
TYR A  95
LEU A 146
 STU  A 601 ( 4.4A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
 0.73A 4v04A-5isoA:
22.4		 4v04A-5isoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		8 / 10 LEU A  22
VAL A  30
LYS A  45
ILE A  77
TYR A  95
ARG A 138
LEU A 146
ILE A 155
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 ( 4.4A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
None
STU  A 601 (-4.5A)
None
 1.22A 4v04B-5isoA:
22.6		 4v04B-5isoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		7 / 12 VAL A  30
ALA A  43
LYS A  45
GLY A  99
ASN A 144
LEU A 146
ALA A 156
 STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 ( 4.0A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.77A 4wa9B-5isoA:
25.1		 4wa9B-5isoA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		4 / 8 LEU A  22
ALA A  43
MET A  93
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.5A)
 0.56A 4wboB-5isoA:
28.0		 4wboB-5isoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		4 / 6 LEU A  22
ALA A  43
MET A  93
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.5A)
 0.56A 4wboC-5isoA:
28.1		 4wboC-5isoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		5 / 12 VAL A  30
ALA A  43
LYS A  45
ASP A 157
PHE A 158
 STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 (-3.5A)
None
 0.70A 4xv2A-5isoA:
25.4		 4xv2A-5isoA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		5 / 12 ALA A  43
LYS A  45
LEU A  68
ASP A 157
PHE A 158
 STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
None
STU  A 601 (-3.5A)
None
 0.84A 4xv2B-5isoA:
25.7		 4xv2B-5isoA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		6 / 12 LEU A  22
ALA A  43
GLY A  99
LEU A 146
ALA A 156
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.0A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
STU  A 601 (-3.5A)
 0.90A 5ajqA-5isoA:
24.0		 5ajqA-5isoA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		5 / 12 VAL A  30
ALA A  43
LYS A  45
LEU A  68
PHE A 158
 STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
None
None
 0.86A 5cswA-5isoA:
25.3		 5cswA-5isoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		6 / 12 GLY A  23
VAL A  30
ALA A  43
LEU A 146
ALA A 156
ASP A 157
 STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
STU  A 601 (-3.5A)
 0.60A 5l2iA-5isoA:
7.8		 5l2iA-5isoA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		7 / 11 LEU A  22
GLY A  23
VAL A  30
ALA A  43
TYR A  95
GLU A 100
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 (-3.4A)
STU  A 601 (-4.5A)
 0.51A 5lvnA-5isoA:
31.7		 5lvnA-5isoA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		5 / 9 GLY A  23
VAL A  30
ALA A  43
ILE A  77
MET A  93
 STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.3A)
STU  A 601 ( 3.9A)
 0.64A 5lw1B-5isoA:
25.1		 5lw1B-5isoA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		5 / 10 GLY A  23
VAL A  30
ALA A  43
ILE A  77
MET A  93
 STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.3A)
STU  A 601 ( 3.9A)
 0.75A 5lw1E-5isoA:
25.0		 5lw1E-5isoA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		7 / 10 LEU A  22
VAL A  30
ALA A  43
MET A  93
TYR A  95
VAL A  96
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-4.0A)
STU  A 601 (-4.5A)
 0.61A 5n3hA-5isoA:
31.0		 5n3hA-5isoA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens) 		5 / 9 LEU A  22
VAL A  30
LYS A  45
ILE A  77
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 ( 4.4A)
STU  A 601 ( 4.3A)
STU  A 601 (-3.5A)
 0.97A 5yf9X-5isoA:
25.2		 5yf9X-5isoA:
10.99