SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5isu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5isu LMO0135 PROTEIN
(Listeria
monocytogenes) 		4 / 7 VAL A 366
TYR A 386
ALA A 283
LEU A 419
 None
 0.81A 1pthA-5isuA:
undetectable		 1pthA-5isuA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5isu LMO0135 PROTEIN
(Listeria
monocytogenes) 		4 / 7 VAL A 366
TYR A 386
ALA A 283
LEU A 419
 None
 0.82A 1pthB-5isuA:
undetectable		 1pthB-5isuA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 5isu LMO0135 PROTEIN
(Listeria
monocytogenes) 		5 / 10 TYR A 500
ASP A 497
ARG A 499
LEU A 522
VAL A 231
 None
 1.49A 1q6iB-5isuA:
undetectable		 1q6iB-5isuA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQJ_A_TRPA650_0
(TRYPTOPHAN
HALOGENASE, PRNA)		 5isu LMO0135 PROTEIN
(Listeria
monocytogenes) 		5 / 11 ILE A 176
PRO A 175
ILE A 197
HIS A 179
PHE A 120
 None
 1.47A 2aqjA-5isuA:
1.2		 2aqjA-5isuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5isu LMO0135 PROTEIN
(Listeria
monocytogenes) 		4 / 6 THR A 169
VAL A 122
VAL A  99
VAL A 155
 None
 0.83A 2z97A-5isuA:
undetectable		 2z97A-5isuA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5isu LMO0135 PROTEIN
(Listeria
monocytogenes) 		5 / 12 PHE A 181
ILE A 187
GLN A  67
VAL A 213
LEU A 215
 None
 1.24A 3em0B-5isuA:
undetectable		 3em0B-5isuA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 5isu LMO0135 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ILE A  44
LEU A  42
LEU A 496
GLY A 200
PRO A 201
 None
 1.12A 3ozwB-5isuA:
undetectable		 3ozwB-5isuA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5isu LMO0135 PROTEIN
(Listeria
monocytogenes) 		4 / 8 GLN A 344
GLU A 388
GLN A 384
ILE A 378
 None
 1.00A 4dx7B-5isuA:
2.3		 4dx7B-5isuA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5isu LMO0135 PROTEIN
(Listeria
monocytogenes) 		4 / 8 THR A 169
VAL A 122
VAL A  99
VAL A 155
 None
 0.88A 4l4bA-5isuA:
undetectable		 4l4bA-5isuA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5isu LMO0135 PROTEIN
(Listeria
monocytogenes) 		4 / 8 ASP A 490
SER A 281
ALA A 314
SER A 374
 None
 1.16A 4lv9A-5isuA:
undetectable
4lv9B-5isuA:
undetectable		 4lv9A-5isuA:
21.99
4lv9B-5isuA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5isu LMO0135 PROTEIN
(Listeria
monocytogenes) 		4 / 7 ASP A 490
SER A 281
ALA A 314
SER A 374
 None
 1.21A 4lv9A-5isuA:
undetectable
4lv9B-5isuA:
undetectable		 4lv9A-5isuA:
21.99
4lv9B-5isuA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5isu LMO0135 PROTEIN
(Listeria
monocytogenes) 		3 / 3 GLU A 265
TYR A 320
GLU A 319
 None
 0.62A 4ryaA-5isuA:
3.4		 4ryaA-5isuA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 5isu LMO0135 PROTEIN
(Listeria
monocytogenes) 		5 / 11 ALA A 304
ALA A 300
VAL A 353
LEU A 301
LEU A 393
 None
 1.26A 5eb5A-5isuA:
undetectable		 5eb5A-5isuA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 5isu LMO0135 PROTEIN
(Listeria
monocytogenes) 		5 / 10 PRO A 160
PHE A 157
ALA A 115
VAL A 122
PRO A 144
 None
 1.40A 5m0oA-5isuA:
undetectable		 5m0oA-5isuA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 5isu LMO0135 PROTEIN
(Listeria
monocytogenes) 		5 / 12 TYR A 334
LEU A 454
SER A 326
GLN A 475
ASP A 429
 None
 1.38A 6bxlA-5isuA:
undetectable		 6bxlA-5isuA:
20.86