SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5isx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5isx GRAMICIDIN S
SYNTHASE 1
(Brevibacillus
brevis) 		5 / 11 LEU A 920
VAL A 918
MET A 935
LEU A 939
HIS A1055
 None
 1.35A 1kt6A-5isxA:
undetectable		 1kt6A-5isxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5isx GRAMICIDIN S
SYNTHASE 1
(Brevibacillus
brevis) 		5 / 11 LEU A 920
VAL A 918
MET A 935
LEU A 939
HIS A1055
 None
 1.36A 1kt7A-5isxA:
undetectable		 1kt7A-5isxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5isx GRAMICIDIN S
SYNTHASE 1
(Brevibacillus
brevis) 		4 / 5 ASP A 868
MET A 935
ASN A 859
TYR A 916
 None
 1.49A 1nbiA-5isxA:
0.0		 1nbiA-5isxA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5isx GRAMICIDIN S
SYNTHASE 1
(Brevibacillus
brevis) 		4 / 5 ASP A 868
MET A 935
ASN A 859
TYR A 916
 None
 1.49A 1nbiB-5isxA:
0.0		 1nbiB-5isxA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A933_1
(ANDROGEN RECEPTOR)		 5isx GRAMICIDIN S
SYNTHASE 1
(Brevibacillus
brevis) 		5 / 10 ILE A 715
GLY A 997
ASN A 998
PHE A1023
GLU A1025
 None
 1.39A 2piwA-5isxA:
undetectable		 2piwA-5isxA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 5isx GRAMICIDIN S
SYNTHASE 1
(Brevibacillus
brevis) 		3 / 3 ASP A 788
THR A 627
PRO A 628
 None
 0.48A 2q64B-5isxA:
undetectable		 2q64B-5isxA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 5isx GRAMICIDIN S
SYNTHASE 1
(Brevibacillus
brevis) 		4 / 7 ALA A 771
THR A 770
ALA A 769
PRO A 784
 None
 0.94A 2ql8A-5isxA:
undetectable
2ql8B-5isxA:
undetectable		 2ql8A-5isxA:
12.89
2ql8B-5isxA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5isx GRAMICIDIN S
SYNTHASE 1
(Brevibacillus
brevis) 		4 / 8 THR A 913
GLN A 915
TYR A1015
TRP A 644
 PNS  A1200 (-3.6A)
None
None
None
 1.29A 2xz5A-5isxA:
undetectable
2xz5C-5isxA:
undetectable		 2xz5A-5isxA:
15.71
2xz5C-5isxA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5isx GRAMICIDIN S
SYNTHASE 1
(Brevibacillus
brevis) 		3 / 3 LEU A 955
TRP A 813
TYR A 800
 None
 0.99A 3aicF-5isxA:
undetectable		 3aicF-5isxA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 5isx GRAMICIDIN S
SYNTHASE 1
(Brevibacillus
brevis) 		4 / 5 ILE A 951
TYR A 916
ILE A 629
HIS A 631
 None
 1.22A 3eteB-5isxA:
undetectable
3eteC-5isxA:
undetectable		 3eteB-5isxA:
20.60
3eteC-5isxA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 5isx GRAMICIDIN S
SYNTHASE 1
(Brevibacillus
brevis) 		6 / 12 LEU A1000
LEU A 977
GLN A 979
TYR A 648
ASP A 983
THR A 982
 None
PNS  A1200 (-4.8A)
None
None
None
None
 1.43A 3gwuA-5isxA:
undetectable		 3gwuA-5isxA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 5isx GRAMICIDIN S
SYNTHASE 1
(Brevibacillus
brevis) 		3 / 3 ASP A 788
THR A 627
PRO A 628
 None
 0.48A 3tkgD-5isxA:
undetectable		 3tkgD-5isxA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 5isx GRAMICIDIN S
SYNTHASE 1
(Brevibacillus
brevis) 		3 / 3 TYR A 586
ARG A 582
SER A 585
 None
 1.11A 4khpI-5isxA:
undetectable
4khpJ-5isxA:
undetectable		 4khpI-5isxA:
14.94
4khpJ-5isxA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 5isx GRAMICIDIN S
SYNTHASE 1
(Brevibacillus
brevis) 		4 / 6 GLU A 892
ILE A 629
HIS A 753
TYR A1015
 PNS  A1200 ( 4.7A)
None
PNS  A1200 (-4.2A)
None
 1.00A 4qwpA-5isxA:
undetectable		 4qwpA-5isxA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 5isx GRAMICIDIN S
SYNTHASE 1
(Brevibacillus
brevis) 		3 / 3 ASP A 767
HIS A 672
LYS A 667
 None
 1.00A 4qzuD-5isxA:
undetectable		 4qzuD-5isxA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5isx GRAMICIDIN S
SYNTHASE 1
(Brevibacillus
brevis) 		5 / 12 ALA A 750
ILE A 751
ASN A 998
LEU A1000
GLY A 758
 None
None
None
None
PNS  A1200 (-4.3A)
 1.22A 4r38A-5isxA:
undetectable		 4r38A-5isxA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5isx GRAMICIDIN S
SYNTHASE 1
(Brevibacillus
brevis) 		4 / 5 GLU A 808
GLU A 809
TYR A 812
GLU A 811
 None
 1.49A 4r87E-5isxA:
undetectable		 4r87E-5isxA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5isx GRAMICIDIN S
SYNTHASE 1
(Brevibacillus
brevis) 		5 / 11 GLY A 618
ASP A 792
ILE A 795
SER A 794
ASP A 673
 None
 1.25A 4rtrA-5isxA:
undetectable		 4rtrA-5isxA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5isx GRAMICIDIN S
SYNTHASE 1
(Brevibacillus
brevis) 		5 / 10 GLY A 910
GLY A 758
SER A 760
ARG A 762
ILE A 763
 None
PNS  A1200 (-4.3A)
None
None
None
 0.92A 5aqfA-5isxA:
2.0		 5aqfA-5isxA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 5isx GRAMICIDIN S
SYNTHASE 1
(Brevibacillus
brevis) 		5 / 10 GLY A 910
GLY A 758
SER A 760
ARG A 762
ILE A 763
 None
PNS  A1200 (-4.3A)
None
None
None
 0.94A 5aqfC-5isxA:
undetectable		 5aqfC-5isxA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 5isx GRAMICIDIN S
SYNTHASE 1
(Brevibacillus
brevis) 		5 / 10 GLY A 910
GLY A 758
SER A 760
ARG A 762
ILE A 763
 None
PNS  A1200 (-4.3A)
None
None
None
 0.88A 5aqyA-5isxA:
undetectable		 5aqyA-5isxA:
21.66