SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5it3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 5it3 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A
(Homo
sapiens) 		3 / 3 HIS A 253
PHE A 210
PHE A 196
 None
 0.71A 3lk0D-5it3A:
undetectable		 3lk0D-5it3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5it3 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A
(Homo
sapiens) 		5 / 10 THR A 234
ILE A 227
ASN A 263
LEU A 256
LEU A 222
 None
 1.40A 4r3aB-5it3A:
undetectable		 4r3aB-5it3A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 5it3 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A
(Homo
sapiens) 		3 / 3 LEU A 261
LEU A 183
ARG A 214
 None
 0.52A 6fgcA-5it3A:
undetectable		 6fgcA-5it3A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 5it3 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A
(Homo
sapiens) 		3 / 3 LEU A 261
LEU A 183
ARG A 214
 None
 0.56A 6fgdA-5it3A:
undetectable		 6fgdA-5it3A:
12.41