SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5it5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF
(Thermus
thermophilus) 		4 / 4 ILE F 740
LEU F 834
VAL F 637
ILE F 770
 None
 0.86A 1fm6D-5it5F:
undetectable		 1fm6D-5it5F:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF
(Thermus
thermophilus) 		5 / 10 VAL F 760
ALA F 733
ASN F 764
ALA F 768
ILE F 644
 None
 0.98A 1likA-5it5F:
undetectable		 1likA-5it5F:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF
(Thermus
thermophilus) 		5 / 11 ALA F 726
LEU F 769
LEU F 755
LEU F 646
ARG F 754
 None
 1.07A 2ceoA-5it5F:
undetectable		 2ceoA-5it5F:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF
(Thermus
thermophilus) 		5 / 12 ASP F 523
ILE F 542
ASP F 543
GLY F 544
HIS F 528
 ATP  F 902 ( 4.9A)
None
None
None
None
 1.32A 2pgfA-5it5F:
undetectable		 2pgfA-5it5F:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF
(Thermus
thermophilus) 		5 / 10 ALA F 751
ALA F 749
GLU F 833
ALA F 748
SER F 774
 None
 1.42A 2r2vC-5it5F:
undetectable
2r2vF-5it5F:
undetectable
2r2vG-5it5F:
undetectable		 2r2vC-5it5F:
6.81
2r2vF-5it5F:
6.81
2r2vG-5it5F:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF
(Thermus
thermophilus) 		5 / 10 ALA F 726
LEU F 769
LEU F 755
LEU F 646
ARG F 754
 None
 1.09A 2riwA-5it5F:
undetectable
2riwB-5it5F:
undetectable		 2riwA-5it5F:
22.08
2riwB-5it5F:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF
(Thermus
thermophilus) 		5 / 10 ALA F 726
LEU F 769
LEU F 755
LEU F 646
ARG F 754
 None
 1.13A 2xn6A-5it5F:
undetectable
2xn6B-5it5F:
undetectable		 2xn6A-5it5F:
21.25
2xn6B-5it5F:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF
(Thermus
thermophilus) 		5 / 10 ALA F 726
LEU F 769
LEU F 755
LEU F 646
ARG F 754
 None
 1.12A 2xn7A-5it5F:
undetectable
2xn7B-5it5F:
undetectable		 2xn7A-5it5F:
21.25
2xn7B-5it5F:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF
(Thermus
thermophilus) 		4 / 5 ILE F 662
SER F 661
PHE F 657
PRO F 619
 None
None
ATP  F 902 (-3.9A)
None
 1.31A 3bjwC-5it5F:
undetectable		 3bjwC-5it5F:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF
(Thermus
thermophilus) 		4 / 5 ALA F 749
LEU F 769
GLY F 771
THR F 658
 None
 0.90A 3dl9A-5it5F:
undetectable		 3dl9A-5it5F:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF
(Thermus
thermophilus) 		4 / 8 VAL F 515
VAL F 564
MET F 567
ILE F 529
 None
 1.03A 3remA-5it5F:
undetectable		 3remA-5it5F:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF
(Thermus
thermophilus) 		5 / 12 LEU F 540
ILE F 529
TYR F 549
VAL F 563
PHE F 511
 None
 1.18A 3vw1D-5it5F:
undetectable		 3vw1D-5it5F:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EBK_A_TOYA301_1
(AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE)		 5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF
(Thermus
thermophilus) 		5 / 9 GLU F 890
GLU F 833
ASP F 747
GLU F 856
ALA F 858
 None
 1.35A 4ebkA-5it5F:
0.8
4ebkB-5it5F:
0.0		 4ebkA-5it5F:
20.67
4ebkB-5it5F:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF
(Thermus
thermophilus) 		3 / 3 SER F 525
ARG F 541
HIS F 528
 None
 0.93A 4mjwA-5it5F:
undetectable
4mjwB-5it5F:
undetectable		 4mjwA-5it5F:
22.71
4mjwB-5it5F:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF
(Thermus
thermophilus) 		5 / 12 ILE F 831
ALA F 874
LEU F 885
ALA F 886
THR F 879
 None
 0.81A 4psyA-5it5F:
undetectable		 4psyA-5it5F:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF
(Thermus
thermophilus) 		5 / 12 ARG F 754
ALA F 851
ILE F 765
LEU F 769
GLY F 771
 None
 0.96A 4r3aB-5it5F:
2.8		 4r3aB-5it5F:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF
(Thermus
thermophilus) 		5 / 9 ALA F 809
LEU F 885
LEU F 796
LEU F 881
ARG F 867
 None
 1.26A 4x30A-5it5F:
undetectable		 4x30A-5it5F:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF
(Thermus
thermophilus) 		3 / 3 ILE F 684
PRO F 685
ILE F 687
 None
 0.37A 5hw8F-5it5F:
undetectable		 5hw8F-5it5F:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF
(Thermus
thermophilus) 		5 / 12 LEU F 755
THR F 730
ILE F 644
GLY F 643
ILE F 770
 None
 1.15A 5ifuA-5it5F:
2.1		 5ifuA-5it5F:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF
(Thermus
thermophilus) 		3 / 3 GLY F 814
CYH F 785
CYH F 782
 None
ZN  F 901 (-2.3A)
ZN  F 901 (-2.4A)
 0.98A 5inzB-5it5F:
undetectable		 5inzB-5it5F:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF
(Thermus
thermophilus) 		4 / 7 ASP F 747
ALA F 851
GLU F 856
LEU F 835
 None
 1.09A 6ci6A-5it5F:
undetectable		 6ci6A-5it5F:
11.60