SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5it9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5it9 RIBOSOMAL PROTEIN
ES12
(Kluyveromyces
lactis) 		4 / 8 LEU M  79
ALA M  53
VAL M 113
VAL M 111
 None
 0.83A 1epbB-5it9M:
undetectable		 1epbB-5it9M:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDW_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5it9 RIBOSOMAL PROTEIN
ES24
(Kluyveromyces
lactis) 		5 / 10 VAL Y  57
LEU Y  44
VAL Y  27
PHE Y  60
GLU Y  39
 None
 1.32A 1fdwA-5it9Y:
undetectable		 1fdwA-5it9Y:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 5it9 RIBOSOMAL PROTEIN
RACK1
(Kluyveromyces
lactis) 		4 / 4 GLY g 311
VAL g 316
TRP g  20
GLY g  19
 None
 1.30A 1ng8A-5it9g:
undetectable		 1ng8A-5it9g:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 5it9 RIBOSOMAL PROTEIN
RACK1
(Kluyveromyces
lactis) 		4 / 4 GLY g 311
VAL g 316
TRP g  20
GLY g  19
 None
 1.30A 1ng8B-5it9g:
undetectable		 1ng8B-5it9g:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 5it9 RIBOSOMAL PROTEIN
RACK1
(Kluyveromyces
lactis) 		4 / 8 GLU g 280
THR g 263
ALA g 261
VAL g 247
 None
 0.89A 1sn5C-5it9g:
undetectable		 1sn5C-5it9g:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 5it9 RIBOSOMAL PROTEIN
US15
(Kluyveromyces
lactis) 		3 / 3 GLN N  36
ILE N  37
TYR N  40
 None
 0.64A 1vifA-5it9N:
undetectable		 1vifA-5it9N:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 5it9 RIBOSOMAL PROTEIN
RACK1
(Kluyveromyces
lactis) 		3 / 3 ASP g 271
ARG g 256
ASP g 279
 None
 0.93A 1vptA-5it9g:
undetectable		 1vptA-5it9g:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 5it9 RIBOSOMAL PROTEIN
RACK1
(Kluyveromyces
lactis) 		3 / 3 ASP g  77
GLU g 101
TYR g  62
 None
 0.84A 1wsvA-5it9g:
undetectable		 1wsvA-5it9g:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 5it9 RIBOSOMAL PROTEIN
ES19
(Kluyveromyces
lactis) 		4 / 5 ILE T 135
SER T 125
ARG T 130
LEU T 132
 None
None
G  21357 ( 4.6A)
None
 1.13A 1y0xX-5it9T:
undetectable		 1y0xX-5it9T:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5it9 RIBOSOMAL PROTEIN
RACK1
(Kluyveromyces
lactis) 		5 / 12 LEU g  14
VAL g 319
LEU g  95
LEU g  43
TYR g  62
 None
 1.24A 2prgB-5it9g:
undetectable		 2prgB-5it9g:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5it9 RIBOSOMAL PROTEIN
RACK1
(Kluyveromyces
lactis) 		3 / 3 VAL g 316
ASP g 314
GLU g  15
 None
 0.70A 2qeuA-5it9g:
undetectable		 2qeuA-5it9g:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5it9 RIBOSOMAL PROTEIN
RACK1
(Kluyveromyces
lactis) 		3 / 3 VAL g 316
ASP g 314
GLU g  15
 None
 0.69A 2qeuC-5it9g:
undetectable		 2qeuC-5it9g:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5it9 RIBOSOMAL PROTEIN
RACK1
(Kluyveromyces
lactis) 		5 / 12 SER g  36
LEU g  14
LEU g  95
LEU g  43
TYR g  62
 None
 1.46A 3adsA-5it9g:
undetectable		 3adsA-5it9g:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 5it9 RIBOSOMAL PROTEIN
RACK1
(Kluyveromyces
lactis) 		5 / 12 ASN g  18
ILE g  44
GLY g  19
THR g  42
GLY g 311
 G  21406 ( 4.1A)
None
None
None
None
 0.84A 3uq6A-5it9g:
undetectable		 3uq6A-5it9g:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 5it9 RIBOSOMAL PROTEIN
RACK1
(Kluyveromyces
lactis) 		5 / 12 ASN g  18
ILE g  44
GLY g  19
THR g  42
GLY g 311
 G  21406 ( 4.1A)
None
None
None
None
 0.87A 3vaqA-5it9g:
undetectable		 3vaqA-5it9g:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 5it9 RIBOSOMAL PROTEIN
RACK1
(Kluyveromyces
lactis) 		5 / 12 ASN g  18
ILE g  44
GLY g  19
THR g  42
GLY g 311
 G  21406 ( 4.1A)
None
None
None
None
 0.86A 3vasA-5it9g:
undetectable		 3vasA-5it9g:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5it9 RIBOSOMAL PROTEIN
RACK1
(Kluyveromyces
lactis) 		4 / 8 TRP g 186
TYR g 143
VAL g 157
ILE g 132
 None
 0.98A 4aftD-5it9g:
undetectable
4aftE-5it9g:
undetectable		 4aftD-5it9g:
22.12
4aftE-5it9g:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 5it9 RIBOSOMAL PROTEIN
US15
(Kluyveromyces
lactis) 		4 / 5 ALA N  57
HIS N  58
GLN N  36
TYR N  40
 None
 1.08A 4gboA-5it9N:
undetectable		 4gboA-5it9N:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 5it9 RIBOSOMAL PROTEIN
US15
(Kluyveromyces
lactis) 		4 / 5 ALA N  57
HIS N  58
GLN N  36
TYR N  40
 None
 1.17A 4gboB-5it9N:
undetectable		 4gboB-5it9N:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5it9 RIBOSOMAL PROTEIN
RACK1
(Kluyveromyces
lactis) 		5 / 12 LEU g  14
VAL g 319
LEU g  95
LEU g  43
TYR g  62
 None
 1.28A 4o8fB-5it9g:
undetectable		 4o8fB-5it9g:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5it9 RIBOSOMAL PROTEIN
ES19
(Kluyveromyces
lactis) 		5 / 12 GLY T  98
PHE T  14
ILE T 135
LEU T 108
PHE T  54
 G  21500 ( 3.7A)
None
None
None
None
 1.23A 4zdyA-5it9T:
undetectable		 4zdyA-5it9T:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5it9 RIBOSOMAL PROTEIN
ES10
(Kluyveromyces
lactis) 		4 / 6 VAL K  42
HIS K  32
HIS K  14
LEU K  15
 None
 1.50A 5hrqH-5it9K:
undetectable
5hrqK-5it9K:
undetectable
5hrqL-5it9K:
undetectable		 5hrqH-5it9K:
15.56
5hrqK-5it9K:
14.81
5hrqL-5it9K:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5it9 RIBOSOMAL PROTEIN
ES10
RIBOSOMAL PROTEIN
ES29
(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		4 / 4 GLU d   4
PRO K   4
ILE K   3
LEU K   2
 U  21231 ( 4.5A)
None
U  21256 ( 4.6A)
U  21231 ( 4.1A)
 1.12A 5m45A-5it9d:
undetectable		 5m45A-5it9d:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5it9 RIBOSOMAL PROTEIN
ES10
RIBOSOMAL PROTEIN
ES29
(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		4 / 4 GLU d   4
PRO K   4
ILE K   3
LEU K   2
 U  21231 ( 4.5A)
None
U  21256 ( 4.6A)
U  21231 ( 4.1A)
 1.10A 5m45D-5it9d:
undetectable		 5m45D-5it9d:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5it9 RIBOSOMAL PROTEIN
ES10
RIBOSOMAL PROTEIN
ES29
(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		4 / 4 GLU d   4
PRO K   4
ILE K   3
LEU K   2
 U  21231 ( 4.5A)
None
U  21256 ( 4.6A)
U  21231 ( 4.1A)
 1.10A 5m45G-5it9d:
undetectable		 5m45G-5it9d:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5it9 RIBOSOMAL PROTEIN
ES10
RIBOSOMAL PROTEIN
ES29
(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		4 / 4 GLU d   4
PRO K   4
ILE K   3
LEU K   2
 U  21231 ( 4.5A)
None
U  21256 ( 4.6A)
U  21231 ( 4.1A)
 1.13A 5m45J-5it9d:
undetectable		 5m45J-5it9d:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5it9 RIBOSOMAL PROTEIN
RACK1
(Kluyveromyces
lactis) 		5 / 12 GLY g  37
SER g  61
LEU g  43
GLN g  70
VAL g  69
 None
 1.17A 5ubbA-5it9g:
undetectable		 5ubbA-5it9g:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 5it9 RIBOSOMAL PROTEIN
US15
(Kluyveromyces
lactis) 		4 / 5 ALA N  57
HIS N  58
GLN N  36
TYR N  40
 None
 1.04A 5uizA-5it9N:
undetectable		 5uizA-5it9N:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 5it9 RIBOSOMAL PROTEIN
ES24
(Kluyveromyces
lactis) 		4 / 6 GLN Y  22
ASN Y  15
LEU Y  74
PHE Y  58
 None
 0.90A 6ekuA-5it9Y:
undetectable		 6ekuA-5it9Y:
11.81