SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5itg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 10 ALA A 438
GLU A 427
GLU A 434
LEU A 449
PRO A 450
 None
 1.18A 1cmcA-5itgA:
undetectable
1cmcB-5itgA:
undetectable		 1cmcA-5itgA:
13.72
1cmcB-5itgA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 12 GLY A  99
ALA A 100
ILE A  28
GLY A  27
PRO A 275
 None
 0.85A 1hxbA-5itgA:
undetectable		 1hxbA-5itgA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		3 / 3 ASN A 194
PHE A  36
VAL A 228
 None
 0.82A 1kijA-5itgA:
undetectable		 1kijA-5itgA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		4 / 6 PHE A 202
ALA A 206
GLY A 204
TYR A 205
 None
 1.15A 1l5qA-5itgA:
undetectable		 1l5qA-5itgA:
21.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2W_A_MTLA5600_0
(MANNITOL
DEHYDROGENASE)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 9 ASP A 229
LEU A 298
ASN A 299
HIS A 302
LYS A 380
 None
 0.69A 1m2wA-5itgA:
19.0		 1m2wA-5itgA:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2W_B_MTLB6600_0
(MANNITOL
DEHYDROGENASE)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 9 ASP A 229
LEU A 298
ASN A 299
HIS A 302
LYS A 380
 None
 0.70A 1m2wB-5itgA:
42.3		 1m2wB-5itgA:
40.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 12 ALA A 438
GLU A 427
GLU A 434
LEU A 449
PRO A 450
 None
 1.20A 1mj2C-5itgA:
undetectable
1mj2D-5itgA:
undetectable		 1mj2C-5itgA:
13.95
1mj2D-5itgA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 12 ALA A 438
GLU A 427
GLU A 434
LEU A 449
PRO A 450
 None
 1.22A 1mjoC-5itgA:
undetectable
1mjoD-5itgA:
undetectable		 1mjoC-5itgA:
13.95
1mjoD-5itgA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 11 GLU A 427
GLU A 434
LEU A 449
PRO A 450
ALA A 438
 None
 1.18A 1mjqA-5itgA:
undetectable
1mjqB-5itgA:
undetectable		 1mjqA-5itgA:
13.95
1mjqB-5itgA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 10 GLU A 427
GLU A 434
LEU A 449
PRO A 450
ALA A 438
 None
 1.16A 1mjqC-5itgA:
undetectable
1mjqD-5itgA:
undetectable		 1mjqC-5itgA:
13.95
1mjqD-5itgA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 11 GLU A 427
GLU A 434
LEU A 449
PRO A 450
ALA A 438
 None
 1.17A 1mjqI-5itgA:
undetectable
1mjqJ-5itgA:
undetectable		 1mjqI-5itgA:
13.95
1mjqJ-5itgA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		3 / 3 SER A 400
VAL A 469
LEU A 470
 None
 0.63A 1yajG-5itgA:
undetectable		 1yajG-5itgA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		4 / 6 ASP A 442
ARG A 475
ARG A 471
ILE A 468
 None
 0.98A 2yfbB-5itgA:
undetectable		 2yfbB-5itgA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 12 LEU A 330
ASN A 329
LEU A 327
VAL A 317
PHE A 404
 None
 1.27A 2yloA-5itgA:
undetectable		 2yloA-5itgA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 12 ILE A 125
GLU A  41
VAL A  45
LEU A 276
MET A 283
 None
 1.49A 2ziaB-5itgA:
undetectable		 2ziaB-5itgA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		4 / 5 PHE A 202
ALA A 206
GLY A 204
TYR A 205
 None
 1.14A 3bcrA-5itgA:
undetectable		 3bcrA-5itgA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 11 ALA A 300
ASN A 335
LEU A 334
ILE A 358
PHE A 361
 None
 1.12A 3jw5A-5itgA:
undetectable		 3jw5A-5itgA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 9 GLY A 204
ALA A 206
GLY A 166
VAL A 164
ILE A 217
 None
 0.87A 3oxvA-5itgA:
undetectable		 3oxvA-5itgA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 10 ALA A 206
ASP A 210
GLY A 166
VAL A 164
ILE A 217
 None
 1.02A 3oxvB-5itgA:
undetectable		 3oxvB-5itgA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 9 GLY A 204
ALA A 206
GLY A 166
VAL A 164
ILE A 217
 None
 0.88A 3oxvC-5itgA:
undetectable		 3oxvC-5itgA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		4 / 5 CYH A 306
ILE A 373
HIS A 302
LEU A 305
 None
 0.68A 3qpkA-5itgA:
undetectable		 3qpkA-5itgA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 12 GLY A 280
GLU A  86
LEU A  84
MET A  98
ALA A  42
 None
 1.12A 3t7vA-5itgA:
undetectable		 3t7vA-5itgA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		4 / 6 ASP A 189
GLU A 132
GLY A 133
LEU A 191
 None
 1.03A 3w9tB-5itgA:
undetectable		 3w9tB-5itgA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		4 / 6 ASP A 189
GLU A 132
GLY A 133
LEU A 191
 None
 1.02A 3w9tE-5itgA:
undetectable		 3w9tE-5itgA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		4 / 6 ASP A 189
GLU A 132
GLY A 133
LEU A 191
 None
 1.05A 3w9tF-5itgA:
undetectable		 3w9tF-5itgA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 12 PRO A 274
LEU A 276
ILE A  28
ILE A  48
TYR A  82
 None
 1.35A 4a79B-5itgA:
undetectable		 4a79B-5itgA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		3 / 5 GLY A 195
GLY A 226
GLU A 291
 None
 0.48A 4z2eA-5itgA:
undetectable
4z2eD-5itgA:
undetectable		 4z2eA-5itgA:
25.22
4z2eD-5itgA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 9 ALA A 221
PHE A 183
LEU A 172
ILE A 217
PHE A 202
 None
 1.23A 5i73A-5itgA:
undetectable		 5i73A-5itgA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 12 THR A 388
GLY A 301
LEU A 326
LEU A 311
GLY A 405
 None
 1.45A 5jglB-5itgA:
3.5		 5jglB-5itgA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 5itg SORBITOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 9 ASN A 329
ILE A 474
GLU A 462
VAL A 469
MET A 304
 None
 1.46A 6hloA-5itgA:
3.1		 6hloA-5itgA:
21.47