SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5itz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 5itz DESIGNED ANKYRIN
REPEAT PROTEIN
(DARPIN) D1
(synthetic
construct) 		4 / 4 ASP F  13
LEU F  18
LEU F  19
LEU F  14
 None
 1.37A 1u18A-5itzF:
undetectable		 1u18A-5itzF:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 5itz DESIGNED ANKYRIN
REPEAT PROTEIN
(DARPIN) D1
(synthetic
construct) 		5 / 12 TYR F  57
ILE F 128
GLY F  91
GLY F 124
ILE F  95
 None
 0.94A 2fk8A-5itzF:
undetectable		 2fk8A-5itzF:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 5itz DESIGNED ANKYRIN
REPEAT PROTEIN
(DARPIN) D1
(synthetic
construct) 		5 / 11 ILE F  62
LEU F  51
HIS F  69
LEU F  67
ALA F  71
 None
 1.08A 4p65E-5itzF:
undetectable
4p65F-5itzF:
undetectable
4p65J-5itzF:
undetectable
4p65L-5itzF:
undetectable		 4p65E-5itzF:
7.69
4p65F-5itzF:
13.49
4p65J-5itzF:
13.49
4p65L-5itzF:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 5itz DESIGNED ANKYRIN
REPEAT PROTEIN
(DARPIN) D1
(synthetic
construct) 		5 / 12 VAL F  30
LEU F  18
LEU F  51
ILE F  62
ALA F  71
 None
 1.01A 4p65B-5itzF:
undetectable
4p65D-5itzF:
undetectable
4p65I-5itzF:
undetectable
4p65J-5itzF:
undetectable		 4p65B-5itzF:
13.49
4p65D-5itzF:
13.49
4p65I-5itzF:
7.69
4p65J-5itzF:
13.49