SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iu9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 5iu9 PROTOCADHERIN-19
ISOFORM 1
(Danio
rerio) 		4 / 6 LEU A 373
LEU A 398
LEU A 325
LEU A 388
 None
 0.91A 1errA-5iu9A:
undetectable		 1errA-5iu9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 5iu9 PROTOCADHERIN-19
ISOFORM 1
(Danio
rerio) 		5 / 11 VAL A 311
ILE A 275
ILE A 235
VAL A 293
PHE A 254
 None
 1.15A 1gx9A-5iu9A:
undetectable		 1gx9A-5iu9A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 5iu9 PROTOCADHERIN-19
ISOFORM 1
(Danio
rerio) 		3 / 3 PRO A 242
THR A 240
PRO A 213
 None
 0.64A 2d55C-5iu9A:
undetectable		 2d55C-5iu9A:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 5iu9 PROTOCADHERIN-19
ISOFORM 1
(Danio
rerio) 		4 / 7 LEU A 173
PHE A 151
ILE A 115
PHE A 125
 None
 0.92A 2opxA-5iu9A:
undetectable		 2opxA-5iu9A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 5iu9 PROTOCADHERIN-19
ISOFORM 1
(Danio
rerio) 		4 / 7 ILE A 275
TYR A 220
PHE A 215
ASP A 216
 None
 1.10A 2qebA-5iu9A:
undetectable		 2qebA-5iu9A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 5iu9 PROTOCADHERIN-19
ISOFORM 1
(Danio
rerio) 		4 / 7 ILE A 275
TYR A 220
PHE A 215
ASP A 216
 None
 1.08A 2qebB-5iu9A:
undetectable		 2qebB-5iu9A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 5iu9 PROTOCADHERIN-19
ISOFORM 1
(Danio
rerio) 		4 / 7 VAL A 205
ASP A 210
TYR A 181
ILE A 150
 None
CA  A1004 ( 2.5A)
None
None
 0.75A 3avpA-5iu9A:
undetectable		 3avpA-5iu9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 5iu9 PROTOCADHERIN-19
ISOFORM 1
(Danio
rerio) 		4 / 8 GLU A 176
GLU A 249
ASN A 209
GLY A 299
 CA  A1005 ( 2.4A)
None
CA  A1006 (-3.4A)
None
 0.95A 4f93B-5iu9A:
undetectable		 4f93B-5iu9A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iu9 PROTOCADHERIN-19
ISOFORM 1
(Danio
rerio) 		4 / 7 ASP A 174
ASP A 210
ASN A 211
GLU A 117
 CA  A1004 (-3.6A)
CA  A1004 ( 2.5A)
None
CA  A1005 ( 2.8A)
 1.07A 4feuB-5iu9A:
undetectable		 4feuB-5iu9A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iu9 PROTOCADHERIN-19
ISOFORM 1
(Danio
rerio) 		4 / 8 ASP A 174
ASP A 210
ASN A 211
GLU A 117
 CA  A1004 (-3.6A)
CA  A1004 ( 2.5A)
None
CA  A1005 ( 2.8A)
 1.19A 4fewD-5iu9A:
undetectable		 4fewD-5iu9A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5iu9 PROTOCADHERIN-19
ISOFORM 1
(Danio
rerio) 		4 / 8 ASP A 174
ASP A 210
ASN A 211
GLU A 117
 CA  A1004 (-3.6A)
CA  A1004 ( 2.5A)
None
CA  A1005 ( 2.8A)
 1.19A 4fewF-5iu9A:
undetectable		 4fewF-5iu9A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 5iu9 PROTOCADHERIN-19
ISOFORM 1
(Danio
rerio) 		4 / 6 SER A 116
GLY A 248
ASP A 241
GLY A 299
 None
CA  A1006 ( 4.4A)
CA  A1006 (-2.1A)
None
 0.99A 4koeA-5iu9A:
undetectable
4koeB-5iu9A:
undetectable
4koeC-5iu9A:
undetectable		 4koeA-5iu9A:
25.00
4koeB-5iu9A:
25.00
4koeC-5iu9A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5iu9 PROTOCADHERIN-19
ISOFORM 1
(Danio
rerio) 		4 / 6 GLY A 248
ASP A 241
GLY A 299
SER A 116
 CA  A1006 ( 4.4A)
CA  A1006 (-2.1A)
None
None
 0.99A 4z53A-5iu9A:
undetectable
4z53B-5iu9A:
undetectable		 4z53A-5iu9A:
21.32
4z53B-5iu9A:
21.32