SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iud'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 GLU A 789
ARG A 966
LEU A 793
GLU A 485
 None
 0.80A 1cmaA-5iudA:
undetectable
1cmaB-5iudA:
undetectable		 1cmaA-5iudA:
8.50
1cmaB-5iudA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 MET A 776
ASP A 632
ARG A 688
MET A 689
 None
 1.06A 1dtlA-5iudA:
undetectable		 1dtlA-5iudA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 MET A 776
PRO A 496
ARG A 688
MET A 689
 None
 1.19A 1dtlA-5iudA:
undetectable		 1dtlA-5iudA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 5 GLU A 350
GLY A 357
SER A 482
THR A 481
 None
 1.24A 1icvC-5iudA:
undetectable
1icvD-5iudA:
undetectable		 1icvC-5iudA:
13.28
1icvD-5iudA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 9 GLU A 789
ARG A 966
LEU A 793
GLU A 485
GLY A 782
 None
 1.45A 1mjlA-5iudA:
undetectable
1mjlB-5iudA:
undetectable		 1mjlA-5iudA:
8.50
1mjlB-5iudA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 11 GLY A 782
GLU A 789
ARG A 966
LEU A 793
GLU A 485
 None
 1.47A 1mjqA-5iudA:
undetectable
1mjqB-5iudA:
undetectable		 1mjqA-5iudA:
8.50
1mjqB-5iudA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 10 GLY A 782
GLU A 789
ARG A 966
LEU A 793
GLU A 485
 None
 1.48A 1mjqG-5iudA:
undetectable
1mjqH-5iudA:
undetectable		 1mjqG-5iudA:
8.50
1mjqH-5iudA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 ASP A 860
SER A 863
SER A 867
ASP A1039
 None
 1.14A 2obvA-5iudA:
undetectable		 2obvA-5iudA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 ASP A 860
SER A 863
SER A 867
ASP A1039
 None
 1.18A 2p02A-5iudA:
undetectable		 2p02A-5iudA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 6 ILE A 629
ARG A 664
ILE A 662
PHE A 622
 None
 1.02A 2q72A-5iudA:
undetectable		 2q72A-5iudA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 LEU A1050
LEU A1049
ALA A1056
MET A1007
 None
 1.03A 2wekA-5iudA:
undetectable		 2wekA-5iudA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 7 ASP A 632
ARG A 664
VAL A 626
ILE A 629
 None
 1.04A 2yfbA-5iudA:
2.8		 2yfbA-5iudA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 10 ILE A 662
PHE A 622
LEU A 623
ALA A 624
ILE A 639
 None
 0.93A 3falC-5iudA:
undetectable		 3falC-5iudA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 11 ILE A 662
PHE A 622
LEU A 623
ALA A 624
ILE A 639
 None
 0.88A 3fc6A-5iudA:
undetectable		 3fc6A-5iudA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 484
SER A 483
PHE A 487
GLU A 350
ASP A 351
 None
 1.17A 3ko0A-5iudA:
undetectable
3ko0B-5iudA:
undetectable
3ko0C-5iudA:
undetectable
3ko0D-5iudA:
undetectable		 3ko0A-5iudA:
7.87
3ko0B-5iudA:
7.87
3ko0C-5iudA:
7.87
3ko0D-5iudA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 11 GLU A 350
ASP A 351
LEU A 484
SER A 483
PHE A 487
 None
 1.04A 3ko0E-5iudA:
undetectable
3ko0F-5iudA:
undetectable
3ko0G-5iudA:
undetectable
3ko0H-5iudA:
undetectable		 3ko0E-5iudA:
7.87
3ko0F-5iudA:
7.87
3ko0G-5iudA:
7.87
3ko0H-5iudA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 GLU A 350
ASP A 351
LEU A 484
SER A 483
PHE A 487
 None
 1.12A 3ko0G-5iudA:
undetectable
3ko0H-5iudA:
undetectable
3ko0I-5iudA:
undetectable
3ko0J-5iudA:
undetectable		 3ko0G-5iudA:
7.87
3ko0H-5iudA:
7.87
3ko0I-5iudA:
7.87
3ko0J-5iudA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 484
SER A 483
PHE A 487
GLU A 350
ASP A 351
 None
 1.15A 3ko0G-5iudA:
undetectable
3ko0H-5iudA:
undetectable
3ko0I-5iudA:
undetectable
3ko0J-5iudA:
undetectable		 3ko0G-5iudA:
7.87
3ko0H-5iudA:
7.87
3ko0I-5iudA:
7.87
3ko0J-5iudA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 484
SER A 483
PHE A 487
GLU A 350
ASP A 351
 None
 1.15A 3ko0M-5iudA:
undetectable
3ko0N-5iudA:
undetectable
3ko0O-5iudA:
undetectable
3ko0P-5iudA:
undetectable		 3ko0M-5iudA:
7.87
3ko0N-5iudA:
7.87
3ko0O-5iudA:
7.87
3ko0P-5iudA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 11 GLU A 350
ASP A 351
LEU A 484
SER A 483
PHE A 487
 None
 1.10A 3ko0K-5iudA:
undetectable
3ko0L-5iudA:
undetectable
3ko0M-5iudA:
undetectable
3ko0N-5iudA:
undetectable		 3ko0K-5iudA:
7.87
3ko0L-5iudA:
7.87
3ko0M-5iudA:
7.87
3ko0N-5iudA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 GLU A 350
ASP A 351
LEU A 484
SER A 483
PHE A 487
 None
 1.15A 3ko0M-5iudA:
undetectable
3ko0N-5iudA:
undetectable
3ko0O-5iudA:
undetectable
3ko0P-5iudA:
undetectable		 3ko0M-5iudA:
7.87
3ko0N-5iudA:
7.87
3ko0O-5iudA:
7.87
3ko0P-5iudA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		3 / 3 ALA A1221
ARG A1222
LYS A1054
 None
 1.05A 3kp3B-5iudA:
undetectable		 3kp3B-5iudA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 5 HIS A 637
SER A 709
ARG A1082
ASP A1173
 None
 1.50A 3okxB-5iudA:
undetectable		 3okxB-5iudA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 4 VAL A 413
PHE A 389
PHE A 477
VAL A 446
 None
 1.12A 3rv5C-5iudA:
undetectable
3rv5D-5iudA:
undetectable		 3rv5C-5iudA:
7.57
3rv5D-5iudA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 708
VAL A 712
ILE A 755
ILE A 752
ALA A 541
 None
 1.01A 4ltwA-5iudA:
undetectable		 4ltwA-5iudA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		5 / 12 ILE A 662
PHE A 622
LEU A 623
ALA A 624
ILE A 639
 None
 1.02A 4nqaH-5iudA:
undetectable		 4nqaH-5iudA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 ASP A 860
SER A 863
SER A 867
ASP A1039
 None
 1.18A 5a1iA-5iudA:
undetectable		 5a1iA-5iudA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 4 LEU A 537
ILE A 633
PRO A 763
LEU A 766
 None
 1.14A 5eb3A-5iudA:
undetectable		 5eb3A-5iudA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 4 LEU A 960
TYR A 801
PRO A 912
ILE A 915
 None
 1.04A 5esgA-5iudA:
undetectable		 5esgA-5iudA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 6 PHE A 583
VAL A 585
ALA A 561
THR A 745
 None
 1.09A 5t7bA-5iudA:
3.7		 5t7bA-5iudA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 5 GLY A1092
THR A1091
ASN A1093
LYS A1089
 None
 1.21A 5x23A-5iudA:
undetectable		 5x23A-5iudA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 6 PHE A 796
LEU A 792
ALA A 795
ASN A 873
 None
 0.82A 6f88A-5iudA:
undetectable		 6f88A-5iudA:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 ASP A 860
SER A 863
SER A 867
ASP A1039
 None
 1.17A 6fboA-5iudA:
undetectable		 6fboA-5iudA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 ASP A 860
SER A 863
SER A 867
ASP A1039
 None
 1.13A 6fcbA-5iudA:
undetectable		 6fcbA-5iudA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens) 		4 / 8 ASP A 860
SER A 863
SER A 867
ASP A1039
 None
 1.16A 6fcdA-5iudA:
undetectable		 6fcdA-5iudA:
8.06