SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iuf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		3 / 3 ARG A  22
ARG A 264
ARG A  86
 None
A3P  A 401 (-3.6A)
None
 1.05A 1l7fA-5iufA:
undetectable		 1l7fA-5iufA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		3 / 3 ARG A  22
ARG A 264
ARG A  86
 None
A3P  A 401 (-3.6A)
None
 1.04A 1l7hA-5iufA:
undetectable		 1l7hA-5iufA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		4 / 4 HIS A 284
ALA A 287
PHE A 265
GLY A 283
 A3P  A 402 (-3.7A)
A3P  A 401 ( 4.7A)
None
A3P  A 401 (-3.4A)
 1.37A 1mj2B-5iufA:
undetectable		 1mj2B-5iufA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		4 / 4 HIS A 284
ALA A 287
PHE A 265
GLY A 283
 A3P  A 402 (-3.7A)
A3P  A 401 ( 4.7A)
None
A3P  A 401 (-3.4A)
 1.36A 1mj2D-5iufA:
undetectable		 1mj2D-5iufA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		4 / 4 HIS A 284
ALA A 287
PHE A 265
GLY A 283
 A3P  A 402 (-3.7A)
A3P  A 401 ( 4.7A)
None
A3P  A 401 (-3.4A)
 1.39A 1mjoB-5iufA:
undetectable		 1mjoB-5iufA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		4 / 4 HIS A 284
ALA A 287
PHE A 265
GLY A 283
 A3P  A 402 (-3.7A)
A3P  A 401 ( 4.7A)
None
A3P  A 401 (-3.4A)
 1.42A 1mjoA-5iufA:
undetectable		 1mjoA-5iufA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		4 / 4 HIS A 284
ALA A 287
PHE A 265
GLY A 283
 A3P  A 402 (-3.7A)
A3P  A 401 ( 4.7A)
None
A3P  A 401 (-3.4A)
 1.36A 1mjoD-5iufA:
undetectable		 1mjoD-5iufA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		5 / 9 ALA A 146
TYR A 150
ALA A 173
GLY A 174
ILE A 153
 None
 1.21A 2v7bA-5iufA:
undetectable		 2v7bA-5iufA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		5 / 9 ALA A 146
TYR A 150
ALA A 173
GLY A 174
ILE A 153
 None
 1.21A 2v7bB-5iufA:
undetectable		 2v7bB-5iufA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		4 / 8 VAL A 123
ASP A  24
GLY A  29
HIS A  20
 None
 0.75A 3af0A-5iufA:
1.9		 3af0A-5iufA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		5 / 11 LEU A  17
ASP A  13
ILE A   6
ILE A  77
ILE A  15
 None
 0.92A 3ebzA-5iufA:
undetectable		 3ebzA-5iufA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		4 / 5 ARG A  19
ILE A  87
VAL A  76
THR A  35
 None
 1.17A 3eigA-5iufA:
undetectable		 3eigA-5iufA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		4 / 5 ASP A 102
ILE A  87
VAL A  76
THR A  35
 None
 1.08A 3eigA-5iufA:
undetectable		 3eigA-5iufA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		4 / 5 GLN A  31
THR A  35
THR A  70
HIS A  18
 None
 1.49A 3g1uC-5iufA:
undetectable		 3g1uC-5iufA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		5 / 12 LEU A  57
PHE A  59
PHE A 187
LEU A 186
PHE A 160
 None
 1.08A 3tbgA-5iufA:
undetectable		 3tbgA-5iufA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		4 / 6 ASP A  24
TYR A  28
HIS A  20
THR A  81
 None
 1.39A 4paeA-5iufA:
undetectable		 4paeA-5iufA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		5 / 12 GLY A 138
LYS A 140
GLU A 129
LEU A 132
GLU A 136
 None
 1.33A 5nwvA-5iufA:
undetectable		 5nwvA-5iufA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		5 / 10 TYR A  71
ILE A   9
ILE A   6
ILE A  47
ASN A  46
 None
 1.39A 5vkqA-5iufA:
undetectable
5vkqD-5iufA:
undetectable		 5vkqA-5iufA:
10.68
5vkqD-5iufA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		5 / 10 ILE A  47
ASN A  46
TYR A  71
ILE A   9
ILE A   6
 None
 1.38A 5vkqA-5iufA:
undetectable
5vkqB-5iufA:
undetectable		 5vkqA-5iufA:
10.68
5vkqB-5iufA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		5 / 10 ILE A  47
ASN A  46
TYR A  71
ILE A   9
ILE A   6
 None
 1.37A 5vkqC-5iufA:
undetectable
5vkqD-5iufA:
undetectable		 5vkqC-5iufA:
10.68
5vkqD-5iufA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		4 / 6 LEU A 186
GLN A 189
LEU A  57
LEU A  60
 None
 1.18A 5yvnA-5iufA:
undetectable		 5yvnA-5iufA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA
(Bacillus
subtilis) 		4 / 5 THR A  70
ASP A  89
HIS A  18
ARG A  91
 None
 1.45A 6dchA-5iufA:
undetectable		 6dchA-5iufA:
21.45