SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iuy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 145
GLU A 152
LEU A 229
GLY A  53
LEU A  51
 None
 1.03A 1g50B-5iuyA:
undetectable		 1g50B-5iuyA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 145
GLU A 152
LEU A 229
GLY A  53
LEU A  51
 None
 1.03A 1g50C-5iuyA:
undetectable		 1g50C-5iuyA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 369
TYR A  25
ILE A 255
GLY A 431
 None
 1.03A 1kifA-5iuyA:
undetectable		 1kifA-5iuyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 369
TYR A  25
ILE A 255
GLY A 431
 None
 1.04A 1kifB-5iuyA:
undetectable		 1kifB-5iuyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 369
TYR A  25
ILE A 255
GLY A 431
 None
 1.04A 1kifC-5iuyA:
undetectable		 1kifC-5iuyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 369
TYR A  25
ILE A 255
GLY A 431
 None
 1.03A 1kifD-5iuyA:
undetectable		 1kifD-5iuyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 369
TYR A  25
ILE A 255
GLY A 431
 None
 1.03A 1kifE-5iuyA:
undetectable		 1kifE-5iuyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 369
TYR A  25
ILE A 255
GLY A 431
 None
 1.04A 1kifF-5iuyA:
undetectable		 1kifF-5iuyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 369
TYR A  25
ILE A 255
GLY A 431
 None
 1.04A 1kifG-5iuyA:
undetectable		 1kifG-5iuyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 369
TYR A  25
ILE A 255
GLY A 431
 None
 1.03A 1kifH-5iuyA:
undetectable		 1kifH-5iuyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		5 / 12 SER A 362
GLU A 361
ASP A 141
ALA A 270
ILE A 268
 None
 1.16A 1s14B-5iuyA:
undetectable		 1s14B-5iuyA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 369
TYR A  25
ILE A 255
GLY A 431
 None
 1.04A 1ve9A-5iuyA:
undetectable		 1ve9A-5iuyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 439
GLU A 260
GLY A 259
ALA A  14
ALA A  13
 None
 1.12A 2br4B-5iuyA:
undetectable		 2br4B-5iuyA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		5 / 12 GLN A 232
LEU A 241
LEU A 229
LEU A  46
VAL A  47
 None
 1.12A 2c12C-5iuyA:
undetectable		 2c12C-5iuyA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 369
TYR A  25
ILE A 255
GLY A 431
 None
 1.05A 2du8G-5iuyA:
undetectable		 2du8G-5iuyA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 369
TYR A  25
ILE A 255
GLY A 431
 None
 1.07A 2du8J-5iuyA:
undetectable		 2du8J-5iuyA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 153
LEU A 149
ILE A 226
ARG A 225
 None
None
None
CL  A 503 (-3.0A)
 0.91A 2rlfB-5iuyA:
undetectable
2rlfC-5iuyA:
undetectable		 2rlfB-5iuyA:
7.03
2rlfC-5iuyA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		5 / 9 ALA A  88
ALA A 303
GLY A 304
GLY A 306
ILE A 309
 None
 0.93A 2v7bA-5iuyA:
undetectable		 2v7bA-5iuyA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		5 / 9 ALA A  88
ALA A 303
GLY A 304
GLY A 306
ILE A 309
 None
 0.93A 2v7bB-5iuyA:
undetectable		 2v7bB-5iuyA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 273
ALA A 133
ASP A 132
GLU A 136
 None
 0.81A 2xrzA-5iuyA:
undetectable		 2xrzA-5iuyA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  15
LEU A 439
LEU A 261
GLY A 256
ILE A  17
 None
 1.29A 3lbdA-5iuyA:
undetectable		 3lbdA-5iuyA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 339
ALA A 340
ASP A 281
VAL A 284
 None
 0.69A 3t3cA-5iuyA:
undetectable		 3t3cA-5iuyA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  78
PHE A  79
PRO A  80
 None
 0.64A 3zoaB-5iuyA:
undetectable		 3zoaB-5iuyA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		5 / 9 ALA A  88
ALA A 303
GLY A 304
GLY A 306
ILE A 309
 None
 0.98A 4eatB-5iuyA:
undetectable		 4eatB-5iuyA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 255
LEU A 253
ALA A 434
SER A 438
LEU A 439
 None
 1.24A 4m11C-5iuyA:
undetectable		 4m11C-5iuyA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		4 / 4 ALA A 203
ALA A 206
ALA A 207
ALA A 210
 None
 0.13A 4oadA-5iuyA:
undetectable		 4oadA-5iuyA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		4 / 4 ALA A 203
ALA A 206
ALA A 207
ALA A 210
 None
 0.13A 4oaeA-5iuyA:
undetectable		 4oaeA-5iuyA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		6 / 10 THR A   9
ALA A 276
THR A 279
ALA A 280
ALA A 277
ASP A 132
 None
 1.32A 4qvyK-5iuyA:
undetectable
4qvyL-5iuyA:
undetectable		 4qvyK-5iuyA:
18.32
4qvyL-5iuyA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		6 / 10 THR A   9
ALA A 276
THR A 279
ALA A 280
ALA A 277
ASP A 132
 None
 1.33A 4qvyY-5iuyA:
undetectable
4qvyZ-5iuyA:
undetectable		 4qvyY-5iuyA:
18.32
4qvyZ-5iuyA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		4 / 4 ALA A 280
VAL A 284
GLY A 122
THR A   2
 None
 1.08A 4ubeA-5iuyA:
undetectable		 4ubeA-5iuyA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		5 / 8 LEU A 230
THR A  42
LEU A 241
THR A 238
LEU A 237
 None
 1.15A 4z90F-5iuyA:
2.5
4z90G-5iuyA:
2.8
4z90H-5iuyA:
2.6
4z90I-5iuyA:
undetectable
4z90J-5iuyA:
2.7		 4z90F-5iuyA:
23.08
4z90G-5iuyA:
23.08
4z90H-5iuyA:
23.08
4z90I-5iuyA:
23.08
4z90J-5iuyA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 155
ARG A 430
GLY A 431
GLU A 427
 None
 1.06A 5btfA-5iuyA:
1.5
5btfC-5iuyA:
undetectable
5btfD-5iuyA:
undetectable		 5btfA-5iuyA:
23.41
5btfC-5iuyA:
23.41
5btfD-5iuyA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 161
THR A  42
ASP A  40
 None
 0.96A 5g5gA-5iuyA:
undetectable
5g5gB-5iuyA:
undetectable		 5g5gA-5iuyA:
20.49
5g5gB-5iuyA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		4 / 8 ARG A 372
GLU A 427
GLY A 158
ASP A 155
 None
 1.07A 5kgpA-5iuyA:
undetectable		 5kgpA-5iuyA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		4 / 8 ARG A 372
GLU A 427
GLY A 158
ASP A 155
 None
 1.12A 5kgpB-5iuyA:
undetectable		 5kgpB-5iuyA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN
(Pseudomonas
aeruginosa) 		4 / 8 GLN A 414
ASN A 173
ILE A 169
GLU A 418
 None
 0.65A 6hzpA-5iuyA:
4.0		 6hzpA-5iuyA:
20.87