SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iv8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 SER A 386
GLN A 356
PHE A 376
ASN A 418
 None
 1.16A 1p6kA-5iv8A:
undetectable		 1p6kA-5iv8A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 SER A 386
GLN A 356
PHE A 376
ASN A 418
 None
 1.17A 1p6kB-5iv8A:
undetectable		 1p6kB-5iv8A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		3 / 3 SER A 526
GLY A 544
ARG A 479
 None
 0.65A 1t9wA-5iv8A:
undetectable		 1t9wA-5iv8A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 GLY A 442
GLY A 444
LEU A 446
GLY A 488
ARG A 507
 None
 1.07A 1y4lA-5iv8A:
undetectable		 1y4lA-5iv8A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 SER A 386
GLN A 356
PHE A 376
ASN A 418
 None
 1.18A 1zzqA-5iv8A:
undetectable		 1zzqA-5iv8A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 SER A 386
GLN A 356
PHE A 376
ASN A 418
 None
 1.18A 1zzqB-5iv8A:
undetectable		 1zzqB-5iv8A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 SER A 386
GLN A 356
PHE A 376
ASN A 418
 None
 1.15A 1zzuB-5iv8A:
undetectable		 1zzuB-5iv8A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 GLY A 576
ILE A 622
ALA A 632
ASP A 532
THR A 555
 None
 1.24A 2vdvE-5iv8A:
undetectable		 2vdvE-5iv8A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		5 / 11 GLY A 576
ILE A 622
ALA A 632
ASP A 532
THR A 555
 None
 1.24A 2vdvF-5iv8A:
undetectable		 2vdvF-5iv8A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		5 / 9 PRO A 336
VAL A 333
GLY A 352
PHE A 379
SER A 348
 None
 1.33A 4mm5A-5iv8A:
undetectable		 4mm5A-5iv8A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		4 / 6 ASP A 394
SER A 359
ALA A 389
PHE A 416
 None
 0.98A 4nedA-5iv8A:
undetectable		 4nedA-5iv8A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		4 / 5 ASP A 746
ARG A 381
ARG A 309
THR A 236
 None
 1.49A 4p3qA-5iv8A:
undetectable		 4p3qA-5iv8A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		3 / 3 MET A 769
GLN A 710
TYR A 698
 None
 0.96A 4udcA-5iv8A:
undetectable		 4udcA-5iv8A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 ARG A 266
ASP A 300
ASP A 337
ASP A 341
 None
 1.08A 4xqgA-5iv8A:
undetectable		 4xqgA-5iv8A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		4 / 8 ARG A 266
ASP A 300
ASP A 337
ASP A 341
 None
 1.10A 4xqgB-5iv8A:
undetectable		 4xqgB-5iv8A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		4 / 7 ARG A 381
PHE A 342
ARG A 266
ASP A 294
 None
 1.14A 5a06A-5iv8A:
undetectable		 5a06A-5iv8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		4 / 7 ARG A 381
PHE A 342
ARG A 266
ASP A 294
 None
 1.12A 5a06B-5iv8A:
undetectable		 5a06B-5iv8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		4 / 7 ARG A 381
PHE A 342
ARG A 266
ASP A 294
 None
 1.14A 5a06C-5iv8A:
undetectable		 5a06C-5iv8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		4 / 7 ARG A 381
PHE A 342
ARG A 266
ASP A 294
 None
 1.13A 5a06D-5iv8A:
undetectable		 5a06D-5iv8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		4 / 7 ARG A 381
PHE A 342
ARG A 266
ASP A 294
 None
 1.14A 5a06E-5iv8A:
undetectable		 5a06E-5iv8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		4 / 7 ARG A 381
PHE A 342
ARG A 266
ASP A 294
 None
 1.10A 5a06F-5iv8A:
undetectable		 5a06F-5iv8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 ASP A 629
GLU A 658
LEU A 536
ALA A 632
SER A 656
 None
 1.30A 5hnzB-5iv8A:
undetectable		 5hnzB-5iv8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		4 / 6 ASP A 625
ASP A 607
ASN A 635
GLN A 530
 None
 1.17A 5l6eA-5iv8A:
undetectable		 5l6eA-5iv8A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 ASP A 629
GLU A 658
LEU A 536
ALA A 632
SER A 656
 None
 1.01A 6ew0B-5iv8A:
undetectable		 6ew0B-5iv8A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 ASP A 629
GLU A 658
LEU A 536
ALA A 632
SER A 656
 None
 1.01A 6ew0D-5iv8A:
undetectable		 6ew0D-5iv8A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 ASP A 629
GLU A 658
LEU A 536
ALA A 632
SER A 656
 None
 1.02A 6ew0F-5iv8A:
undetectable		 6ew0F-5iv8A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 ASP A 629
GLU A 658
LEU A 536
ALA A 632
SER A 656
 None
 1.01A 6ew0G-5iv8A:
undetectable		 6ew0G-5iv8A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 ASP A 629
GLU A 658
LEU A 536
ALA A 632
SER A 656
 None
 1.01A 6ew0H-5iv8A:
undetectable		 6ew0H-5iv8A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		5 / 12 ASP A 629
GLU A 658
LEU A 536
ALA A 632
SER A 656
 None
 1.01A 6ew0I-5iv8A:
undetectable		 6ew0I-5iv8A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5iv8 LPS BIOSYNTHESIS
PROTEIN
(Klebsiella
pneumoniae) 		4 / 6 ASP A 643
TYR A 640
GLU A 615
ASP A 614
 None
 1.41A 6mn5C-5iv8A:
undetectable		 6mn5C-5iv8A:
9.35