SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ivl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		4 / 6 ILE B 317
GLU B  81
ASP B 320
PRO B 321
 None
 1.13A 1ditH-5ivlB:
undetectable
1ditP-5ivlB:
undetectable		 1ditH-5ivlB:
19.36
1ditP-5ivlB:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		4 / 4 MET B  20
ALA B  16
TYR B  91
ILE B  93
 None
 1.34A 1upfD-5ivlB:
4.1		 1upfD-5ivlB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		4 / 4 TYR B 219
MET B 363
PRO B 318
ILE B 349
 None
 1.46A 2qm9A-5ivlB:
undetectable		 2qm9A-5ivlB:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		4 / 5 TYR B 313
MET B 341
THR B 342
LEU B 220
 None
 1.47A 3ag1J-5ivlB:
undetectable		 3ag1J-5ivlB:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA315_0
(UNCHARACTERIZED
PROTEIN)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		5 / 11 THR B 342
LYS B 212
ILE B 215
ARG B 330
VAL B 325
 None
 1.26A 3ijdA-5ivlB:
undetectable		 3ijdA-5ivlB:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB315_0
(UNCHARACTERIZED
PROTEIN)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		5 / 12 THR B 342
LYS B 212
ILE B 215
ARG B 330
VAL B 325
 None
 1.16A 3ijdB-5ivlB:
undetectable		 3ijdB-5ivlB:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		3 / 3 ARG B 130
ASP B 164
ASP B 133
 None
 0.83A 3jayA-5ivlB:
2.0		 3jayA-5ivlB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		3 / 3 ARG B 130
ASP B 164
ASP B 133
 None
 0.89A 3jb2A-5ivlB:
3.0		 3jb2A-5ivlB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		4 / 8 ASP B 320
ALA B  77
SER B 323
ASP B 298
 None
 1.04A 4k0bB-5ivlB:
undetectable		 4k0bB-5ivlB:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		4 / 8 ASP B 320
ALA B  77
SER B 323
ASP B 298
 None
 1.06A 4l7iB-5ivlB:
undetectable		 4l7iB-5ivlB:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		4 / 8 GLY B 377
LEU B 419
LEU B 422
GLU B 423
 None
 0.73A 4mwzB-5ivlB:
undetectable		 4mwzB-5ivlB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_A_KANA201_1
(BIFUNCTIONAL AAC/APH)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		5 / 11 TYR B 265
GLY B 264
HIS B 424
GLN B 378
ASP B 236
 None
 1.47A 4qc6A-5ivlB:
0.0		 4qc6A-5ivlB:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		3 / 3 GLY B 129
PRO B 128
ALA B  77
 None
 0.49A 4qn9B-5ivlB:
undetectable		 4qn9B-5ivlB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		5 / 12 ILE B 124
GLN B 108
LYS B 250
THR B 297
VAL B 299
 None
SO4  B 501 (-3.1A)
SO4  B 501 (-4.1A)
None
None
 1.35A 4qzuA-5ivlB:
undetectable		 4qzuA-5ivlB:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		5 / 11 ILE B  28
THR B  48
GLY B  51
PHE B  56
THR B  32
 None
SO4  B 502 (-3.5A)
SO4  B 502 (-3.4A)
None
None
 1.46A 4xt7A-5ivlB:
1.6		 4xt7A-5ivlB:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		5 / 11 THR B  26
THR B  32
GLY B  51
THR B  53
ALA B  54
 None
None
SO4  B 502 (-3.4A)
SO4  B 502 (-3.6A)
None
 1.35A 5bxnV-5ivlB:
undetectable
5bxnW-5ivlB:
undetectable		 5bxnV-5ivlB:
20.60
5bxnW-5ivlB:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		5 / 12 GLY B 338
GLY B 332
ILE B 328
ARG B 333
LEU B 242
 None
 1.18A 5fa8A-5ivlB:
2.1		 5fa8A-5ivlB:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		4 / 6 PHE B  56
PRO B  59
THR B 147
ILE B  60
 None
 1.46A 5ih0A-5ivlB:
undetectable		 5ih0A-5ivlB:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		4 / 7 HIS B 134
ILE B 114
ARG B 130
GLN B 108
 None
None
None
SO4  B 501 (-3.1A)
 1.32A 5kkzM-5ivlB:
undetectable
5kkzO-5ivlB:
undetectable		 5kkzM-5ivlB:
19.52
5kkzO-5ivlB:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		5 / 12 ILE B 114
ILE B  71
LEU B  74
VAL B  76
ILE B 131
 None
 1.09A 5mugA-5ivlB:
undetectable		 5mugA-5ivlB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		4 / 5 TYR B 313
MET B 341
THR B 342
LEU B 220
 None
 1.42A 5wauJ-5ivlB:
undetectable		 5wauJ-5ivlB:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		4 / 5 TYR B 313
MET B 341
THR B 342
LEU B 220
 None
 1.39A 5x1bW-5ivlB:
undetectable		 5x1bW-5ivlB:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		4 / 5 TYR B 313
MET B 341
THR B 342
LEU B 220
 None
 1.39A 5x1fW-5ivlB:
undetectable		 5x1fW-5ivlB:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11801_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		4 / 4 ARG B 252
ARG B 248
GLY B 106
ARG B 130
 None
 1.17A 6az3P-5ivlB:
undetectable		 6az3P-5ivlB:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		5 / 12 VAL B 101
GLU B 322
GLN B 319
PHE B 161
ILE B 165
 None
SO4  B 502 (-4.0A)
None
None
None
 1.28A 6becA-5ivlB:
undetectable
6becB-5ivlB:
undetectable
6becC-5ivlB:
undetectable		 6becA-5ivlB:
19.33
6becB-5ivlB:
19.33
6becC-5ivlB:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		5 / 9 LEU B 242
THR B 310
GLY B 332
PHE B 286
ILE B 244
 None
 1.16A 6ebpA-5ivlB:
undetectable		 6ebpA-5ivlB:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		5 / 10 LEU B 242
THR B 310
GLY B 332
PHE B 286
ILE B 244
 None
 1.15A 6ebpB-5ivlB:
undetectable		 6ebpB-5ivlB:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		5 / 10 LEU B 242
THR B 310
GLY B 332
PHE B 286
ILE B 244
 None
 1.17A 6ebpC-5ivlB:
undetectable		 6ebpC-5ivlB:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		5 / 12 VAL B  42
ASP B  41
GLU B 201
LEU B   9
LEU B   7
 None
 1.04A 6ew0B-5ivlB:
undetectable		 6ew0B-5ivlB:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		5 / 12 VAL B  42
ASP B  41
GLU B 201
LEU B   9
LEU B   7
 None
 1.04A 6ew0D-5ivlB:
undetectable		 6ew0D-5ivlB:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		5 / 12 VAL B  42
ASP B  41
GLU B 201
LEU B   9
LEU B   7
 None
 1.04A 6ew0F-5ivlB:
undetectable		 6ew0F-5ivlB:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		5 / 12 VAL B  42
ASP B  41
GLU B 201
LEU B   9
LEU B   7
 None
 1.03A 6ew0G-5ivlB:
undetectable		 6ew0G-5ivlB:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		5 / 12 VAL B  42
ASP B  41
GLU B 201
LEU B   9
LEU B   7
 None
 1.04A 6ew0H-5ivlB:
undetectable		 6ew0H-5ivlB:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 5ivl DEAD-BOX
ATP-DEPENDENT RNA
HELICASE CSHA
(Geobacillus
stearothermophil
us) 		5 / 12 VAL B  42
ASP B  41
GLU B 201
LEU B   9
LEU B   7
 None
 1.04A 6ew0I-5ivlB:
undetectable		 6ew0I-5ivlB:
10.96