SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ivw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5ivw GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 3
(Homo
sapiens) 		5 / 11 SER 3  35
ILE 3  60
VAL 3  15
LEU 3  34
MET 3 119
 None
 1.28A 1uduA-5ivw3:
undetectable		 1uduA-5ivw3:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ivw GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 3
(Homo
sapiens) 		3 / 3 THR 3 120
GLU 3  66
HIS 3 128
 None
 0.91A 1xwfB-5ivw3:
undetectable		 1xwfB-5ivw3:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ivw GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 3
(Homo
sapiens) 		3 / 3 THR 3 120
GLU 3  66
HIS 3 128
 None
 0.88A 1xwfC-5ivw3:
3.2		 1xwfC-5ivw3:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ivw GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 3
(Homo
sapiens) 		3 / 3 THR 3 120
GLU 3  66
HIS 3 128
 None
 0.90A 1xwfD-5ivw3:
undetectable		 1xwfD-5ivw3:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 5ivw GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 3
(Homo
sapiens) 		5 / 12 LEU 3 162
VAL 3  59
ILE 3 111
VAL 3  43
ILE 3  13
 None
 1.06A 3nu5B-5ivw3:
undetectable		 3nu5B-5ivw3:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5ivw GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 3
(Homo
sapiens) 		5 / 10 PHE 3 177
ILE 3 181
ILE 3 161
LEU 3 203
SER 3  62
 None
 1.22A 3o1cA-5ivw3:
undetectable		 3o1cA-5ivw3:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5ivw GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 3
(Homo
sapiens) 		5 / 10 PHE 3 177
ILE 3 181
ILE 3 161
LEU 3 203
SER 3  62
 None
 1.25A 3o1xA-5ivw3:
undetectable		 3o1xA-5ivw3:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 5ivw GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 3
(Homo
sapiens) 		5 / 10 LEU 3 162
VAL 3  59
ILE 3 111
VAL 3  43
ILE 3  13
 None
 0.99A 3oxwB-5ivw3:
undetectable		 3oxwB-5ivw3:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 5ivw GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 3
(Homo
sapiens) 		5 / 12 ASP 3 169
ILE 3 181
GLN 3 187
ALA 3 184
ILE 3 191
 None
 1.14A 4uroC-5ivw3:
undetectable		 4uroC-5ivw3:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5ivw GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 3
(Homo
sapiens) 		5 / 9 ALA 3 206
GLN 3 205
PHE 3 177
LEU 3 137
ILE 3 191
 None
 1.41A 5i73A-5ivw3:
undetectable		 5i73A-5ivw3:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 5ivw GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 3
(Homo
sapiens) 		5 / 12 LEU 3 162
VAL 3  59
ILE 3 111
VAL 3  43
ILE 3  13
 None
 0.98A 6dh6A-5ivw3:
undetectable		 6dh6A-5ivw3:
15.19