SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iw4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 5iw4 NADH PYROPHOSPHATASE
(Escherichia
coli) 		3 / 4 VAL A  57
TRP A 112
TRP A  55
 None
 1.07A 1gmkA-5iw4A:
undetectable
1gmkB-5iw4A:
undetectable		 1gmkA-5iw4A:
5.02
1gmkB-5iw4A:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5iw4 NADH PYROPHOSPHATASE
(Escherichia
coli) 		4 / 6 LEU A 220
LEU A 143
ILE A 135
GLU A 178
 None
 1.09A 1mt1A-5iw4A:
undetectable
1mt1F-5iw4A:
undetectable		 1mt1A-5iw4A:
12.16
1mt1F-5iw4A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5iw4 NADH PYROPHOSPHATASE
(Escherichia
coli) 		4 / 8 ASN A 224
SER A 140
ARG A 227
ALA A 223
 None
 1.19A 1rqpC-5iw4A:
undetectable		 1rqpC-5iw4A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 5iw4 NADH PYROPHOSPHATASE
(Escherichia
coli) 		4 / 5 ALA A 254
TYR A 256
ALA A 250
TYR A 228
 None
 1.06A 1xl6A-5iw4A:
undetectable
1xl6B-5iw4A:
undetectable		 1xl6A-5iw4A:
21.74
1xl6B-5iw4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		 5iw4 NADH PYROPHOSPHATASE
(Escherichia
coli) 		5 / 11 GLN A  58
GLN A  59
ASP A  37
ARG A  61
PRO A  29
 None
 1.39A 2a68M-5iw4A:
0.0		 2a68M-5iw4A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5iw4 NADH PYROPHOSPHATASE
(Escherichia
coli) 		4 / 8 ASN A 224
SER A 140
ARG A 227
ALA A 223
 None
 1.18A 2v7uA-5iw4A:
undetectable		 2v7uA-5iw4A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 5iw4 NADH PYROPHOSPHATASE
(Escherichia
coli) 		5 / 12 ARG A 148
GLU A 219
LEU A 220
GLU A 178
GLU A 174
 NAD  A 501 ( 4.0A)
None
None
None
None
 1.45A 3k37B-5iw4A:
undetectable		 3k37B-5iw4A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_F_BCZF1001_0
(NEURAMINIDASE)		 5iw4 NADH PYROPHOSPHATASE
(Escherichia
coli) 		5 / 12 ARG A 148
GLU A 219
LEU A 220
GLU A 178
GLU A 174
 NAD  A 501 ( 4.0A)
None
None
None
None
 1.45A 3k39F-5iw4A:
undetectable		 3k39F-5iw4A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 5iw4 NADH PYROPHOSPHATASE
(Escherichia
coli) 		4 / 5 VAL A  68
PRO A 193
MET A 201
VAL A 240
 None
None
NAD  A 501 (-3.5A)
NAD  A 501 (-4.5A)
 1.16A 6ekzA-5iw4A:
undetectable		 6ekzA-5iw4A:
14.79