SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iw9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 5iw9 BASEPLATE WEDGE
PROTEIN GP25
(Escherichia
virus
T4) 		5 / 12 ILE A  40
SER A  35
ILE A  39
CYH A  55
LEU A  91
 None
 1.29A 2ft9A-5iw9A:
undetectable		 2ft9A-5iw9A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5iw9 BASEPLATE WEDGE
PROTEIN GP25
(Escherichia
virus
T4) 		4 / 8 SER A  79
ASN A  76
GLU A  74
ILE A  77
 None
 1.02A 4d33A-5iw9A:
undetectable		 4d33A-5iw9A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5iw9 BASEPLATE WEDGE
PROTEIN GP25
(Escherichia
virus
T4) 		4 / 7 SER A  79
ASN A  76
GLU A  74
ILE A  77
 None
 1.05A 4d33B-5iw9A:
undetectable		 4d33B-5iw9A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5iw9 BASEPLATE WEDGE
PROTEIN GP25
(Escherichia
virus
T4) 		4 / 8 SER A  79
ASN A  76
GLU A  74
ILE A  77
 None
 1.05A 4d39A-5iw9A:
undetectable		 4d39A-5iw9A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5iw9 BASEPLATE WEDGE
PROTEIN GP25
(Escherichia
virus
T4) 		4 / 7 SER A  79
ASN A  76
GLU A  74
ILE A  77
 None
 1.01A 4d39B-5iw9A:
undetectable		 4d39B-5iw9A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 5iw9 BASEPLATE WEDGE
PROTEIN GP25
(Escherichia
virus
T4) 		4 / 8 ILE A  40
LEU A  36
LEU A 124
ILE A  77
 None
 0.76A 4zvcA-5iw9A:
undetectable
4zvcB-5iw9A:
undetectable		 4zvcA-5iw9A:
22.70
4zvcB-5iw9A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 5iw9 BASEPLATE WEDGE
PROTEIN GP25
(Escherichia
virus
T4) 		4 / 8 ILE A  77
ILE A  40
LEU A  36
LEU A 124
 None
 0.76A 4zvcA-5iw9A:
undetectable
4zvcB-5iw9A:
undetectable		 4zvcA-5iw9A:
22.70
4zvcB-5iw9A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5iw9 BASEPLATE WEDGE
PROTEIN GP25
(Escherichia
virus
T4) 		5 / 9 VAL A 106
VAL A  81
LEU A 124
GLY A  38
LEU A  37
 None
 1.27A 6czmA-5iw9A:
undetectable
6czmB-5iw9A:
undetectable		 6czmA-5iw9A:
17.43
6czmB-5iw9A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5iw9 BASEPLATE WEDGE
PROTEIN GP25
(Escherichia
virus
T4) 		5 / 9 VAL A 106
VAL A  81
LEU A 124
GLY A  38
LEU A  37
 None
 1.25A 6czmB-5iw9A:
undetectable
6czmC-5iw9A:
undetectable		 6czmB-5iw9A:
17.43
6czmC-5iw9A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5iw9 BASEPLATE WEDGE
PROTEIN GP25
(Escherichia
virus
T4) 		5 / 9 VAL A 106
VAL A  81
LEU A 124
GLY A  38
LEU A  37
 None
 1.22A 6czmD-5iw9A:
undetectable
6czmE-5iw9A:
undetectable		 6czmD-5iw9A:
17.43
6czmE-5iw9A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5iw9 BASEPLATE WEDGE
PROTEIN GP25
(Escherichia
virus
T4) 		5 / 10 SER A  35
GLY A  38
ILE A  39
PHE A 110
ILE A  32
 None
 1.14A 6ebpB-5iw9A:
undetectable		 6ebpB-5iw9A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5iw9 BASEPLATE WEDGE
PROTEIN GP25
(Escherichia
virus
T4) 		5 / 11 GLY A  38
ILE A  39
PHE A 110
ILE A  88
ILE A  32
 None
 0.97A 6ebzA-5iw9A:
undetectable		 6ebzA-5iw9A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5iw9 BASEPLATE WEDGE
PROTEIN GP25
(Escherichia
virus
T4) 		5 / 11 GLY A  38
ILE A  39
PHE A 110
ILE A  88
ILE A  32
 None
 0.94A 6ebzB-5iw9A:
undetectable		 6ebzB-5iw9A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5iw9 BASEPLATE WEDGE
PROTEIN GP25
(Escherichia
virus
T4) 		5 / 11 GLY A  38
ILE A  39
PHE A 110
ILE A  88
ILE A  32
 None
 0.92A 6ebzC-5iw9A:
undetectable		 6ebzC-5iw9A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5iw9 BASEPLATE WEDGE
PROTEIN GP25
(Escherichia
virus
T4) 		5 / 11 GLY A  38
ILE A  39
PHE A 110
ILE A  88
ILE A  32
 None
 0.96A 6ebzD-5iw9A:
undetectable		 6ebzD-5iw9A:
23.85