SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iwd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5iwd DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
betaherpesvirus
5) 		5 / 9 LEU A 223
ILE A 182
PHE A 226
LEU A 156
ILE A 160
 None
 1.25A 2f78B-5iwdA:
undetectable		 2f78B-5iwdA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 5iwd DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
betaherpesvirus
5) 		4 / 6 ASN A  89
ASN A  82
ILE A  80
THR A  94
 None
 0.94A 2hkkA-5iwdA:
undetectable		 2hkkA-5iwdA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 5iwd DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
betaherpesvirus
5) 		4 / 7 TYR A  20
THR A  94
VAL A  40
VAL A 104
 None
 0.90A 2qbnA-5iwdA:
undetectable		 2qbnA-5iwdA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 5iwd DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
betaherpesvirus
5) 		4 / 7 PHE A  90
LEU A  48
PHE A 102
ILE A  24
 None
 0.95A 2v0mC-5iwdA:
undetectable		 2v0mC-5iwdA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VFT_A_SORA1419_0
(XYLITOL OXIDASE)		 5iwd DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
betaherpesvirus
5) 		5 / 12 VAL A 130
GLN A  51
THR A  79
THR A  39
LYS A  60
 None
6EV  A 302 (-3.3A)
6EV  A 302 (-4.3A)
None
6EV  A 302 (-1.4A)
 1.14A 2vftA-5iwdA:
undetectable		 2vftA-5iwdA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VFU_A_MTLA1419_0
(XYLITOL OXIDASE)		 5iwd DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
betaherpesvirus
5) 		5 / 12 VAL A 130
GLN A  51
THR A  79
THR A  39
LYS A  60
 None
6EV  A 302 (-3.3A)
6EV  A 302 (-4.3A)
None
6EV  A 302 (-1.4A)
 1.17A 2vfuA-5iwdA:
0.0		 2vfuA-5iwdA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5iwd DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
betaherpesvirus
5) 		5 / 12 LEU A  68
ALA A 112
PHE A  90
LEU A  27
THR A  94
 None
 1.28A 4iaqA-5iwdA:
undetectable		 4iaqA-5iwdA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 5iwd DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
betaherpesvirus
5) 		3 / 3 TYR A 227
GLY A 161
PRO A 162
 None
 0.68A 4qwpA-5iwdA:
undetectable		 4qwpA-5iwdA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 5iwd DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
betaherpesvirus
5) 		5 / 12 MET A 116
ILE A 114
LEU A  99
PHE A  90
THR A  94
 None
 1.14A 5byjA-5iwdA:
undetectable		 5byjA-5iwdA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5iwd DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
betaherpesvirus
5) 		5 / 10 ASP A 147
ALA A 190
ILE A 191
GLY A 213
SER A 210
 None
 1.24A 5i6xA-5iwdA:
undetectable		 5i6xA-5iwdA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5iwd DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
betaherpesvirus
5) 		5 / 12 SER A 127
PHE A  42
LEU A  68
LEU A  48
VAL A  40
 None
 1.16A 5tudA-5iwdA:
undetectable		 5tudA-5iwdA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5iwd DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
betaherpesvirus
5) 		5 / 9 ASP A 147
ALA A 190
ILE A 191
GLY A 213
SER A 210
 None
 1.20A 6awoA-5iwdA:
undetectable		 6awoA-5iwdA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5iwd DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
betaherpesvirus
5) 		5 / 9 ASP A 147
ALA A 190
ILE A 191
GLY A 213
SER A 210
 None
 1.21A 6awqA-5iwdA:
undetectable		 6awqA-5iwdA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 5iwd DNA POLYMERASE
PROCESSIVITY FACTOR
(Human
betaherpesvirus
5) 		5 / 12 MET A 116
ILE A 114
LEU A  99
PHE A  90
THR A  94
 None
 1.23A 6b54A-5iwdA:
undetectable		 6b54A-5iwdA:
19.74