SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iww'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5iww MULTIPLE ORGANELLAR
RNA EDITING FACTOR
9, CHLOROPLASTIC
PLS9-PPR
(Arabidopsis
thaliana;
unidentified) 		3 / 3 LYS D 181
ASP A 145
ASP A 164
 None
 0.96A 2br4D-5iwwD:
undetectable		 2br4D-5iwwD:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 5iww MULTIPLE ORGANELLAR
RNA EDITING FACTOR
9, CHLOROPLASTIC
PLS9-PPR
(Arabidopsis
thaliana;
unidentified) 		4 / 7 SER D 182
LEU A  82
PHE D 141
GLY A  84
 None
 1.01A 2v0mC-5iwwD:
undetectable		 2v0mC-5iwwD:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 5iww MULTIPLE ORGANELLAR
RNA EDITING FACTOR
9, CHLOROPLASTIC
PLS9-PPR
(Arabidopsis
thaliana;
unidentified) 		5 / 12 VAL A 169
LEU A  82
SER A 165
VAL D 145
ILE D 175
 None
 1.32A 3frqA-5iwwA:
undetectable		 3frqA-5iwwA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5iww PLS9-PPR
(unidentified) 		4 / 5 TYR D  77
THR D  54
PRO D  50
VAL D  17
 None
 1.21A 4mjqA-5iwwD:
undetectable		 4mjqA-5iwwD:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 5iww MULTIPLE ORGANELLAR
RNA EDITING FACTOR
9, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 TYR A 179
ILE A 184
GLY A 176
PHE A 132
 None
 0.87A 5nooA-5iwwA:
undetectable		 5nooA-5iwwA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5iww MULTIPLE ORGANELLAR
RNA EDITING FACTOR
9, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 LEU A 115
LYS A 127
LEU A 119
GLU A 124
 None
 1.33A 5weaA-5iwwA:
2.9		 5weaA-5iwwA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 5iww PLS9-PPR
(unidentified) 		4 / 5 HIS D 277
MET D 298
VAL D 291
LEU D 261
 None
 1.28A 5xdhD-5iwwD:
undetectable		 5xdhD-5iwwD:
14.16