SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ix8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Bordetella
parapertussis) 		5 / 12 THR A 248
GLY A 251
GLY A 226
VAL A 288
VAL A 267
 None
 1.03A 1n2xA-5ix8A:
3.0		 1n2xA-5ix8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Bordetella
parapertussis) 		4 / 6 ALA A 123
TYR A  96
ILE A 146
PRO A 121
 None
EDO  A 503 (-4.6A)
None
None
 1.25A 1oniB-5ix8A:
undetectable
1oniC-5ix8A:
undetectable		 1oniB-5ix8A:
21.00
1oniC-5ix8A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Bordetella
parapertussis) 		3 / 3 VAL A  50
ALA A  51
HIS A 308
 None
 0.80A 1q23L-5ix8A:
undetectable		 1q23L-5ix8A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Bordetella
parapertussis) 		4 / 7 GLU A 309
ALA A 304
LEU A  57
ALA A  80
 None
 1.16A 1sn0B-5ix8A:
undetectable
1sn0D-5ix8A:
undetectable		 1sn0B-5ix8A:
18.81
1sn0D-5ix8A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Bordetella
parapertussis) 		5 / 11 THR A 230
GLY A 251
THR A 245
ASP A 225
VAL A 185
 None
 1.17A 2a1nA-5ix8A:
undetectable		 2a1nA-5ix8A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Bordetella
parapertussis) 		5 / 12 THR A 245
THR A 230
GLY A 251
GLY A 226
MET A 227
 None
 0.88A 2b25B-5ix8A:
2.1		 2b25B-5ix8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Bordetella
parapertussis) 		5 / 11 ILE A 280
LEU A 285
GLY A 253
ALA A 254
VAL A 267
 None
 0.83A 2fxdA-5ix8A:
undetectable		 2fxdA-5ix8A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Bordetella
parapertussis) 		3 / 3 ASP A 232
THR A 245
PRO A 246
 None
 0.67A 2q64B-5ix8A:
undetectable		 2q64B-5ix8A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Bordetella
parapertussis) 		5 / 12 THR A  60
THR A 111
VAL A 114
GLY A  58
ALA A 117
 None
 1.09A 2x2iA-5ix8A:
undetectable		 2x2iA-5ix8A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Bordetella
parapertussis) 		4 / 8 GLU A 291
SER A 270
VAL A  61
HIS A  63
 None
None
None
EDO  A 503 ( 4.7A)
 1.22A 3b9lA-5ix8A:
undetectable		 3b9lA-5ix8A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Bordetella
parapertussis) 		5 / 11 LEU A  57
ILE A 153
GLY A 156
VAL A 157
VAL A  59
 None
 0.93A 3oxxD-5ix8A:
undetectable		 3oxxD-5ix8A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Bordetella
parapertussis) 		5 / 12 LEU A 285
ALA A 258
VAL A 243
THR A 269
VAL A 267
 None
 0.86A 3so9B-5ix8A:
undetectable		 3so9B-5ix8A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Bordetella
parapertussis) 		3 / 3 ASP A 232
THR A 245
PRO A 246
 None
 0.65A 3tkgD-5ix8A:
undetectable		 3tkgD-5ix8A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Bordetella
parapertussis) 		4 / 5 ASN A 149
SER A 322
LEU A 158
ASN A 329
 None
 1.27A 4n09C-5ix8A:
undetectable		 4n09C-5ix8A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Bordetella
parapertussis) 		4 / 6 SER A 322
GLY A 200
GLU A 199
ASP A 160
 None
 0.97A 4uckB-5ix8A:
undetectable		 4uckB-5ix8A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Bordetella
parapertussis) 		4 / 6 LEU A 119
LEU A 134
VAL A 131
PHE A 109
 None
 1.07A 4uswA-5ix8A:
undetectable		 4uswA-5ix8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Bordetella
parapertussis) 		4 / 7 VAL A 185
LEU A 223
GLY A 253
ALA A 254
 None
 0.86A 5f1aB-5ix8A:
undetectable		 5f1aB-5ix8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Bordetella
parapertussis) 		5 / 12 GLN A 105
VAL A  62
ALA A 104
ALA A 123
LEU A 191
 None
 1.06A 5kirB-5ix8A:
undetectable		 5kirB-5ix8A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_1
(SULFOTRANSFERASE)		 5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Bordetella
parapertussis) 		4 / 4 TYR A  69
ASP A  66
ASP A 161
SER A 270
 None
 1.27A 5tiwA-5ix8A:
0.0		 5tiwA-5ix8A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN
(Bordetella
parapertussis) 		5 / 12 LEU A 286
VAL A 182
LEU A 168
ALA A 171
LEU A 172
 None
 1.13A 6ajiA-5ix8A:
undetectable		 6ajiA-5ix8A:
18.65