SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ixd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 12 LEU A 266
LEU A 195
ALA A 201
ASN A 252
SER A 259
 None
 1.14A 1dfoA-5ixdA:
undetectable		 1dfoA-5ixdA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 12 LEU A 266
LEU A 195
ALA A 201
ASN A 252
SER A 259
 None
 1.14A 1dfoB-5ixdA:
undetectable		 1dfoB-5ixdA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 12 LEU A 266
LEU A 195
ALA A 201
ASN A 252
SER A 259
 None
 1.14A 1dfoC-5ixdA:
undetectable		 1dfoC-5ixdA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 12 LEU A 266
LEU A 195
ALA A 201
ASN A 252
SER A 259
 None
 1.14A 1dfoD-5ixdA:
undetectable		 1dfoD-5ixdA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 12 LEU A 266
LEU A 195
ALA A 201
ASN A 252
SER A 259
 None
 1.12A 1eqbA-5ixdA:
undetectable		 1eqbA-5ixdA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 12 LEU A 266
LEU A 195
ALA A 201
ASN A 252
SER A 259
 None
 1.13A 1eqbB-5ixdA:
undetectable		 1eqbB-5ixdA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 12 LEU A 266
LEU A 195
ALA A 201
ASN A 252
SER A 259
 None
 1.13A 1eqbC-5ixdA:
undetectable		 1eqbC-5ixdA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 12 LEU A 266
LEU A 195
ALA A 201
ASN A 252
SER A 259
 None
 1.13A 1eqbD-5ixdA:
undetectable		 1eqbD-5ixdA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		3 / 3 TRP A 116
HIS A 264
LYS A 267
 None
 1.48A 1l7xA-5ixdA:
undetectable		 1l7xA-5ixdA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		3 / 3 LEU A 155
HIS A 264
LYS A 267
 None
 1.12A 1y7iA-5ixdA:
undetectable		 1y7iA-5ixdA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA602_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		4 / 5 HIS A 420
ILE A 436
PRO A 548
ASP A 418
 None
 0.92A 2f7fA-5ixdA:
1.2		 2f7fA-5ixdA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 9 ILE A 323
GLY A 322
GLY A 319
SER A 407
SER A 404
 None
 0.92A 2qmmA-5ixdA:
undetectable		 2qmmA-5ixdA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 11 ILE A 323
GLY A 322
GLY A 319
SER A 407
SER A 404
 None
 0.97A 2qmmA-5ixdA:
undetectable
2qmmB-5ixdA:
undetectable		 2qmmA-5ixdA:
16.36
2qmmB-5ixdA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 12 LEU A 274
THR A 273
ALA A 272
LEU A 158
LEU A 195
 None
 1.06A 3hm1A-5ixdA:
undetectable		 3hm1A-5ixdA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 10 GLY A 162
PHE A 159
CYH A 189
ILE A 221
MET A 192
 None
 1.43A 3ko0L-5ixdA:
undetectable
3ko0N-5ixdA:
undetectable		 3ko0L-5ixdA:
12.01
3ko0N-5ixdA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 9 ASP A 410
ASP A 426
ILE A 377
ILE A 384
LEU A 408
 None
 1.12A 3u7sA-5ixdA:
undetectable		 3u7sA-5ixdA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 9 ALA A 193
LEU A 277
LEU A 166
LEU A 225
ASN A 226
 None
 1.21A 3wdmC-5ixdA:
undetectable		 3wdmC-5ixdA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		3 / 3 TYR A  41
HIS A 106
ARG A 108
 None
 1.21A 4e7bC-5ixdA:
undetectable		 4e7bC-5ixdA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 5ixd INTERFERON LAMBDA
RECEPTOR 1
TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		4 / 6 TRP B 257
ASN A 226
TYR A 217
LEU A 190
 None
 1.15A 4f8yA-5ixdB:
undetectable
4f8yB-5ixdB:
undetectable		 4f8yA-5ixdB:
16.49
4f8yB-5ixdB:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 5ixd INTERFERON LAMBDA
RECEPTOR 1
TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		4 / 7 TYR A 217
LEU A 190
TRP B 257
ASN A 226
 None
 1.24A 4f8yC-5ixdA:
undetectable
4f8yD-5ixdA:
undetectable		 4f8yC-5ixdA:
13.76
4f8yD-5ixdA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 9 LEU A 155
MET A 202
SER A 262
LEU A 266
VAL A 268
 None
 1.11A 4x3mB-5ixdA:
undetectable		 4x3mB-5ixdA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		4 / 6 ILE A 384
VAL A 381
PHE A 405
THR A 288
 None
 1.18A 4xe5A-5ixdA:
undetectable		 4xe5A-5ixdA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 10 SER A 404
ILE A  95
ALA A  57
LEU A  80
ALA A  79
 None
 1.48A 4xk8B-5ixdA:
undetectable		 4xk8B-5ixdA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 10 SER A 404
ILE A  95
ALA A  57
LEU A  80
ALA A  79
 None
 1.46A 5oy0b-5ixdA:
undetectable		 5oy0b-5ixdA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		4 / 5 PRO A 222
THR A 224
ASN A 226
LYS A 227
 None
 1.22A 5x23A-5ixdA:
undetectable		 5x23A-5ixdA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_B_PQNB2002_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens) 		5 / 9 SER A 404
ILE A  95
ALA A  57
LEU A  80
ALA A  79
 None
 1.46A 6hqbB-5ixdA:
undetectable		 6hqbB-5ixdA:
10.15