SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ixm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5ixm LPS-ASSEMBLY PROTEIN
LPTD
(Yersinia
pestis) 		5 / 12 TYR A 359
LEU A 315
SER A 334
SER A 379
TRP A 382
 None
 1.50A 1rk3A-5ixmA:
undetectable		 1rk3A-5ixmA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis) 		5 / 11 ALA B 144
VAL B  88
LEU B  55
LEU B 139
GLN B 138
 None
 1.17A 1rlbF-5ixmB:
undetectable		 1rlbF-5ixmB:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 5ixm LPS-ASSEMBLY PROTEIN
LPTD
(Yersinia
pestis) 		3 / 3 SER A 119
VAL A 108
LEU A  86
 None
 0.75A 1yajG-5ixmA:
undetectable		 1yajG-5ixmA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis) 		4 / 6 ILE B  32
ARG B  56
THR B  54
LEU B  17
 None
 0.99A 2einN-5ixmB:
undetectable
2einW-5ixmB:
undetectable		 2einN-5ixmB:
15.20
2einW-5ixmB:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 5ixm LPS-ASSEMBLY PROTEIN
LPTD
(Yersinia
pestis) 		4 / 7 ASN A 501
GLY A 540
MET A 544
SER A 462
 None
 1.21A 2o5yH-5ixmA:
undetectable
2o5yL-5ixmA:
undetectable		 2o5yH-5ixmA:
17.99
2o5yL-5ixmA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis) 		3 / 3 GLU B 129
GLN B 134
ARG B 137
 None
 0.93A 2w3bB-5ixmB:
undetectable		 2w3bB-5ixmB:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis) 		4 / 6 ILE B  32
ARG B  56
THR B  54
LEU B  17
 None
 1.01A 3ag1N-5ixmB:
undetectable
3ag1W-5ixmB:
undetectable		 3ag1N-5ixmB:
15.20
3ag1W-5ixmB:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 5ixm LPS-ASSEMBLY PROTEIN
LPTD
LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis;
Yersinia
pestis) 		3 / 3 SER A 322
GLU B 121
ASP A 304
 None
 0.83A 3bwyA-5ixmA:
undetectable		 3bwyA-5ixmA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
LPS-ASSEMBLY PROTEIN
LPTD
(Yersinia
pestis) 		4 / 5 LYS A 397
VAL B  67
ILE A 415
TYR A 418
 None
 1.49A 3gvuA-5ixmA:
undetectable		 3gvuA-5ixmA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
LPS-ASSEMBLY PROTEIN
LPTD
(Yersinia
pestis) 		3 / 3 GLN A 309
PHE B 107
TYR A 437
 None
 0.78A 3ucjB-5ixmA:
undetectable		 3ucjB-5ixmA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
LPS-ASSEMBLY PROTEIN
LPTD
(Yersinia
pestis) 		3 / 3 GLN A 309
PHE B 107
TYR A 437
 None
 0.82A 3ucjA-5ixmA:
undetectable		 3ucjA-5ixmA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis) 		5 / 10 GLY B  59
LEU B 135
LEU B  28
ASP B  23
ILE B  32
 None
 1.13A 3wdmD-5ixmB:
undetectable		 3wdmD-5ixmB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis) 		4 / 6 ILE B  32
ARG B  56
THR B  54
LEU B  17
 None
 1.05A 3wg7N-5ixmB:
undetectable
3wg7W-5ixmB:
undetectable		 3wg7N-5ixmB:
15.20
3wg7W-5ixmB:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 5ixm LPS-ASSEMBLY PROTEIN
LPTD
LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis;
Yersinia
pestis) 		3 / 3 ARG B 128
ASP A 170
GLN A 168
 None
 0.91A 4azsA-5ixmB:
undetectable		 4azsA-5ixmB:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 5ixm LPS-ASSEMBLY PROTEIN
LPTD
LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis;
Yersinia
pestis) 		4 / 6 GLN B 130
ARG B 137
GLN B 125
GLU A 225
 None
 1.10A 4azvA-5ixmB:
undetectable		 4azvA-5ixmB:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJK_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 5ixm LPS-ASSEMBLY PROTEIN
LPTD
LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis;
Yersinia
pestis) 		5 / 12 GLU B 121
ASN A 102
LYS A 149
GLN A 168
GLN A 188
 None
 1.37A 4njkA-5ixmB:
undetectable		 4njkA-5ixmB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJK_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 5ixm LPS-ASSEMBLY PROTEIN
LPTD
LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis;
Yersinia
pestis) 		5 / 12 GLU B 121
ASN A 102
LYS A 149
GLN A 168
GLN A 188
 None
 1.35A 4njkB-5ixmB:
undetectable		 4njkB-5ixmB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WZM_A_ACTA503_0
(RNA DEPENDENT RNA
POLYMERASE)		 5ixm LPS-ASSEMBLY PROTEIN
LPTD
(Yersinia
pestis) 		4 / 4 ASP A 116
ASP A 110
ASP A  69
ALA A 112
 None
 1.22A 4wzmA-5ixmA:
undetectable		 4wzmA-5ixmA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
LPS-ASSEMBLY PROTEIN
LPTD
(Yersinia
pestis) 		4 / 4 GLN A 553
THR B  66
GLU B  77
LEU B 123
 None
 1.32A 5m66A-5ixmA:
undetectable		 5m66A-5ixmA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5ixm LPS-ASSEMBLY PROTEIN
LPTD
LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis;
Yersinia
pestis) 		4 / 5 TYR A 128
ALA B  75
GLN B  64
THR B  66
 None
 1.37A 5n4iA-5ixmA:
undetectable		 5n4iA-5ixmA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis) 		3 / 3 VAL B  84
VAL B 100
GLN B 130
 None
 0.55A 5qgjA-5ixmB:
undetectable		 5qgjA-5ixmB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis) 		3 / 3 VAL B  84
VAL B 100
GLN B 130
 None
 0.57A 5qgmA-5ixmB:
undetectable		 5qgmA-5ixmB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis) 		3 / 3 VAL B  84
VAL B 100
GLN B 130
 None
 0.51A 5qgnA-5ixmB:
undetectable		 5qgnA-5ixmB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis) 		3 / 3 VAL B  84
VAL B 100
GLN B 130
 None
 0.58A 5qgyA-5ixmB:
undetectable		 5qgyA-5ixmB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis) 		3 / 3 VAL B  84
VAL B 100
GLN B 130
 None
 0.60A 5qgzA-5ixmB:
undetectable		 5qgzA-5ixmB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis) 		3 / 3 VAL B  84
VAL B 100
GLN B 130
 None
 0.60A 5qh0A-5ixmB:
undetectable		 5qh0A-5ixmB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis) 		3 / 3 VAL B  84
VAL B 100
GLN B 130
 None
 0.59A 5qh2A-5ixmB:
undetectable		 5qh2A-5ixmB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis) 		3 / 3 VAL B  84
VAL B 100
GLN B 130
 None
 0.59A 5qh3A-5ixmB:
undetectable		 5qh3A-5ixmB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis) 		3 / 3 VAL B  84
VAL B 100
GLN B 130
 None
 0.53A 5qh5A-5ixmB:
undetectable		 5qh5A-5ixmB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis) 		3 / 3 VAL B  84
VAL B 100
GLN B 130
 None
 0.58A 5qh6A-5ixmB:
undetectable		 5qh6A-5ixmB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis) 		3 / 3 VAL B  84
VAL B 100
GLN B 130
 None
 0.57A 5qh7A-5ixmB:
undetectable		 5qh7A-5ixmB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis) 		3 / 3 VAL B  84
VAL B 100
GLN B 130
 None
 0.65A 5qhaA-5ixmB:
undetectable		 5qhaA-5ixmB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis) 		3 / 3 VAL B  84
VAL B 100
GLN B 130
 None
 0.60A 5qhhA-5ixmB:
undetectable		 5qhhA-5ixmB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 5ixm LPS-ASSEMBLY PROTEIN
LPTD
(Yersinia
pestis) 		3 / 3 ARG A 326
ARG A 204
ARG A 319
 None
 1.01A 5vcgA-5ixmA:
undetectable		 5vcgA-5ixmA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 5ixm LPS-ASSEMBLY PROTEIN
LPTD
(Yersinia
pestis) 		4 / 8 GLY A 366
GLN A 235
TYR A 303
ASP A 299
 None
 0.85A 5vlmB-5ixmA:
undetectable		 5vlmB-5ixmA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 5ixm LPS-ASSEMBLY PROTEIN
LPTD
(Yersinia
pestis) 		4 / 7 GLY A 366
GLN A 235
TYR A 303
ASP A 299
 None
 0.98A 5vlmE-5ixmA:
undetectable		 5vlmE-5ixmA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 5ixm LPS-ASSEMBLY PROTEIN
LPTD
(Yersinia
pestis) 		4 / 7 GLY A 366
GLN A 235
TYR A 303
ASP A 299
 None
 0.83A 5vlmG-5ixmA:
undetectable		 5vlmG-5ixmA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5ixm LPS-ASSEMBLY PROTEIN
LPTD
(Yersinia
pestis) 		4 / 5 PRO A  75
GLY A  74
THR A  78
LYS A  80
 None
 1.16A 5x23A-5ixmA:
undetectable		 5x23A-5ixmA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE
(Yersinia
pestis) 		5 / 12 VAL B 100
VAL B  84
VAL B  41
PRO B  53
THR B  54
 None
 1.06A 6brdC-5ixmB:
undetectable		 6brdC-5ixmB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 5ixm LPS-ASSEMBLY PROTEIN
LPTD
(Yersinia
pestis) 		4 / 4 LEU A 324
ASP A 304
GLN A 168
VAL A 211
 None
 1.45A 6bzoF-5ixmA:
undetectable		 6bzoF-5ixmA:
22.06