SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ixp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		5 / 12 TYR A  57
GLY A 153
THR A 154
LEU A  47
LEU A 333
 None
 0.89A 1jipA-5ixpA:
undetectable		 1jipA-5ixpA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		4 / 7 ARG A 164
ASP A 273
THR A 294
GLY A 293
 None
 0.93A 2f6dA-5ixpA:
undetectable		 2f6dA-5ixpA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		4 / 7 GLY A 153
THR A 338
PHE A  55
PHE A  52
 None
 1.13A 2qx4A-5ixpA:
undetectable
2qx4B-5ixpA:
undetectable		 2qx4A-5ixpA:
22.77
2qx4B-5ixpA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		5 / 9 SER A 324
LEU A 333
ALA A 328
GLY A 151
LEU A 122
 None
 0.94A 2v0mB-5ixpA:
undetectable		 2v0mB-5ixpA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		3 / 3 ARG A 398
GLU A 401
SER A 145
 None
 0.82A 2xctD-5ixpA:
undetectable		 2xctD-5ixpA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		4 / 5 LEU A 318
GLN A 342
THR A 338
THR A  51
 None
 1.21A 2zj0B-5ixpA:
undetectable		 2zj0B-5ixpA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		4 / 5 LEU A 318
GLN A 342
THR A 338
THR A  51
 None
 1.16A 2zj0C-5ixpA:
undetectable		 2zj0C-5ixpA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		4 / 4 LEU A 318
GLN A 342
THR A 338
THR A  51
 None
 1.21A 2zj0D-5ixpA:
undetectable		 2zj0D-5ixpA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		4 / 5 LEU A 318
GLN A 342
THR A 338
THR A  51
 None
 1.15A 3ce6B-5ixpA:
undetectable		 3ce6B-5ixpA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		4 / 7 LEU A 233
GLU A 236
ASP A 235
SER A 227
 None
 1.40A 3dzgA-5ixpA:
undetectable		 3dzgA-5ixpA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		4 / 6 ILE A 109
THR A 154
PHE A  55
PHE A  52
 None
 1.19A 3elzB-5ixpA:
undetectable		 3elzB-5ixpA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		4 / 6 HIS A  84
GLU A 102
PHE A 119
GLN A 323
 None
 1.46A 3gclA-5ixpA:
undetectable		 3gclA-5ixpA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		4 / 5 ARG A 195
LEU A 173
ILE A 161
PHE A 184
 None
 1.29A 3ln1D-5ixpA:
undetectable		 3ln1D-5ixpA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		3 / 3 ARG A 164
ARG A 165
TRP A 300
 None
 1.30A 4b7nA-5ixpA:
undetectable		 4b7nA-5ixpA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		3 / 3 ARG A 164
ARG A 165
TRP A 300
 None
 1.31A 4cpzC-5ixpA:
undetectable		 4cpzC-5ixpA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		3 / 3 ARG A 164
ARG A 165
TRP A 300
 None
 1.38A 4cpzE-5ixpA:
undetectable		 4cpzE-5ixpA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		3 / 3 ARG A 164
ARG A 165
TRP A 300
 None
 1.29A 4cpzF-5ixpA:
undetectable		 4cpzF-5ixpA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		3 / 3 ARG A 164
ARG A 165
TRP A 300
 None
 1.29A 4cpzG-5ixpA:
undetectable		 4cpzG-5ixpA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		3 / 3 ARG A 164
ARG A 165
TRP A 300
 None
 1.28A 4cpzH-5ixpA:
undetectable		 4cpzH-5ixpA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		4 / 7 ARG A 218
ASN A 403
GLU A 401
ILE A 402
 None
 1.09A 4d39B-5ixpA:
undetectable		 4d39B-5ixpA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		4 / 5 LYS A 332
LEU A 333
GLU A 329
LEU A  47
 None
 1.30A 4k4yA-5ixpA:
undetectable		 4k4yA-5ixpA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		4 / 4 LYS A 332
LEU A 333
GLU A 329
LEU A  47
 None
 1.31A 4k4yE-5ixpA:
undetectable		 4k4yE-5ixpA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		4 / 5 LYS A 332
LEU A 333
GLU A 329
LEU A  47
 None
 1.33A 4k4yI-5ixpA:
undetectable		 4k4yI-5ixpA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		4 / 8 ALA A 210
SER A 256
ALA A 411
ALA A 261
 None
 0.70A 4twdF-5ixpA:
undetectable
4twdG-5ixpA:
undetectable
4twdH-5ixpA:
undetectable
4twdI-5ixpA:
undetectable
4twdJ-5ixpA:
undetectable		 4twdF-5ixpA:
21.62
4twdG-5ixpA:
21.62
4twdH-5ixpA:
21.62
4twdI-5ixpA:
21.62
4twdJ-5ixpA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		4 / 8 ALA A 261
ALA A 210
SER A 256
ALA A 411
 None
 0.68A 4twdF-5ixpA:
undetectable
4twdG-5ixpA:
undetectable
4twdH-5ixpA:
undetectable
4twdI-5ixpA:
undetectable
4twdJ-5ixpA:
undetectable		 4twdF-5ixpA:
21.62
4twdG-5ixpA:
21.62
4twdH-5ixpA:
21.62
4twdI-5ixpA:
21.62
4twdJ-5ixpA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		4 / 8 ALA A 261
ALA A 210
SER A 256
ALA A 411
 None
 0.68A 4twdF-5ixpA:
undetectable
4twdG-5ixpA:
undetectable
4twdH-5ixpA:
undetectable
4twdI-5ixpA:
undetectable
4twdJ-5ixpA:
undetectable		 4twdF-5ixpA:
21.62
4twdG-5ixpA:
21.62
4twdH-5ixpA:
21.62
4twdI-5ixpA:
21.62
4twdJ-5ixpA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		4 / 7 GLU A  75
TYR A  61
GLU A  54
TYR A  57
 None
 1.21A 4zz8A-5ixpA:
undetectable		 4zz8A-5ixpA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		3 / 3 ARG A  77
TYR A  61
GLU A  75
 None
 0.62A 4zzbE-5ixpA:
undetectable		 4zzbE-5ixpA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		4 / 5 GLN A 342
THR A 338
THR A  51
LEU A 333
 None
 1.22A 6aphA-5ixpA:
undetectable		 6aphA-5ixpA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_2
(-)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		4 / 4 GLN A 342
THR A 338
THR A  51
LEU A 333
 None
 1.20A 6f3mA-5ixpA:
undetectable		 6f3mA-5ixpA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_2
(-)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		4 / 4 GLN A 342
THR A 338
THR A  51
LEU A 333
 None
 1.20A 6f3mC-5ixpA:
undetectable		 6f3mC-5ixpA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1
(Kribbella
flavida) 		4 / 5 GLN A 342
THR A 338
THR A  51
LEU A 333
 None
 1.25A 6gbnB-5ixpA:
undetectable		 6gbnB-5ixpA:
22.65