SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ixq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
4 / 5 GLU A 310
THR A 284
LEU A 306
LEU A 307
None
1.22A 1u18B-5ixqA:
undetectable
1u18B-5ixqA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
4 / 6 SER A 555
PHE A 599
ASN A 576
ASP A 553
NAG  A 712 (-2.5A)
None
NAG  A 712 (-1.8A)
NAG  A 712 ( 4.5A)
0.95A 1yc2A-5ixqA:
undetectable
1yc2A-5ixqA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
4 / 5 PRO A 180
GLY A 184
ASN A 185
GLY A 160
None
None
NAG  A 706 (-1.9A)
None
1.18A 1zlqA-5ixqA:
undetectable
1zlqA-5ixqA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
5 / 12 LEU A 434
LEU A 410
ILE A 447
LEU A 381
VAL A 375
None
1.09A 2hrcB-5ixqA:
undetectable
2hrcB-5ixqA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
5 / 8 ILE A 458
GLY A 482
LEU A 506
LEU A 511
PHE A 487
None
1.32A 2vctA-5ixqA:
undetectable
2vctA-5ixqA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
4 / 8 ILE A 458
LEU A 506
LEU A 511
PHE A 487
None
0.87A 2vctB-5ixqA:
undetectable
2vctB-5ixqA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
5 / 8 ILE A 458
GLY A 482
LEU A 506
LEU A 511
PHE A 487
None
1.35A 2vctC-5ixqA:
undetectable
2vctC-5ixqA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
4 / 7 LEU A 296
ASN A 294
GLU A 316
MET A 280
None
1.16A 2w8yA-5ixqA:
undetectable
2w8yA-5ixqA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
4 / 8 LEU A 309
LEU A 314
ASN A 313
LEU A 336
None
1.04A 2xn3A-5ixqA:
undetectable
2xn3B-5ixqA:
undetectable
2xn3A-5ixqA:
21.91
2xn3B-5ixqA:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
4 / 6 LEU A 170
GLY A 148
LEU A 168
SER A 167
None
0.90A 3aiaA-5ixqA:
undetectable
3aiaA-5ixqA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
4 / 5 ILE A 586
PRO A 587
TYR A 590
TYR A 595
None
1.25A 3d9lA-5ixqA:
undetectable
3d9lY-5ixqA:
undetectable
3d9lA-5ixqA:
12.44
3d9lY-5ixqA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
4 / 5 PRO A 564
ILE A 563
PRO A 587
TYR A 590
None
1.40A 3d9lA-5ixqA:
undetectable
3d9lY-5ixqA:
undetectable
3d9lA-5ixqA:
12.44
3d9lY-5ixqA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
4 / 6 LEU A 384
VAL A 408
PHE A 423
PHE A 439
None
1.07A 3soaA-5ixqA:
undetectable
3soaA-5ixqA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
5 / 12 LEU A 144
LEU A 208
GLY A 160
PHE A 162
ILE A 155
None
1.04A 3uwlD-5ixqA:
undetectable
3uwlD-5ixqA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
5 / 12 LEU A 121
PHE A 162
ILE A 155
ILE A 130
PHE A  81
None
1.11A 3w67D-5ixqA:
undetectable
3w67D-5ixqA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
5 / 12 PRO A 348
LEU A 351
LEU A 312
ILE A 327
PHE A 289
None
1.27A 4a79A-5ixqA:
undetectable
4a79A-5ixqA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
5 / 12 PRO A 348
LEU A 351
LEU A 312
ILE A 327
PHE A 289
None
1.31A 4a79B-5ixqA:
undetectable
4a79B-5ixqA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
4 / 8 SER A  74
SER A  73
ASN A  99
GLY A  58
NAG  A 701 (-3.5A)
None
None
None
0.91A 4af0A-5ixqA:
undetectable
4af0A-5ixqA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
4 / 6 SER A 481
SER A 435
ASP A 436
GLU A 484
MG  A 715 (-3.1A)
MG  A 715 (-3.8A)
None
None
1.20A 4eysA-5ixqA:
undetectable
4eysA-5ixqA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
5 / 12 ALA A 531
LEU A 528
ILE A 539
PRO A 540
LEU A 567
NAG  A 712 ( 4.8A)
None
None
None
None
0.94A 4gh8A-5ixqA:
undetectable
4gh8A-5ixqA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
4 / 5 GLU A 433
SER A 459
ARG A 409
SER A 481
None
MG  A 715 (-3.0A)
None
MG  A 715 (-3.1A)
1.44A 4k17B-5ixqA:
5.6
4k17B-5ixqA:
27.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
4 / 8 LEU A 528
VAL A 543
LEU A 511
LEU A 535
None
0.98A 4l1xA-5ixqA:
undetectable
4l1xA-5ixqA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
5 / 12 ILE A 443
ILE A 477
LEU A 504
LEU A 506
ILE A 467
None
0.99A 4m2xA-5ixqA:
undetectable
4m2xA-5ixqA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
5 / 12 ILE A 443
ILE A 477
LEU A 504
LEU A 506
ILE A 467
None
0.96A 4m2xC-5ixqA:
undetectable
4m2xC-5ixqA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
5 / 12 ILE A 443
ILE A 477
LEU A 504
LEU A 506
ILE A 467
None
1.01A 4m2xE-5ixqA:
undetectable
4m2xE-5ixqA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
4 / 8 GLU A 479
ASP A 505
SER A 459
TRP A 424
None
None
MG  A 715 (-3.0A)
None
1.07A 4uhxA-5ixqA:
undetectable
4uhxA-5ixqA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
5 / 12 LEU A 189
LEU A 217
LEU A 183
THR A 178
ILE A 155
None
1.18A 4x1yB-5ixqA:
undetectable
4x1yB-5ixqA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
5 / 10 SER A  95
LEU A 134
LEU A 105
LEU A 121
LEU A 151
None
1.13A 4yiaA-5ixqA:
undetectable
4yiaA-5ixqA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
4 / 6 LEU A 276
MET A 283
THR A 284
LEU A 306
None
1.05A 5x1fA-5ixqA:
undetectable
5x1fJ-5ixqA:
undetectable
5x1fA-5ixqA:
22.09
5x1fJ-5ixqA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
5 / 9 ILE A 443
SER A 459
PHE A 463
SER A 466
GLY A 465
None
MG  A 715 (-3.0A)
None
None
None
1.38A 6awpA-5ixqA:
undetectable
6awpA-5ixqA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
5 / 10 SER A 494
LEU A 456
LEU A 501
ILE A 447
PRO A 468
None
1.26A 6dlzB-5ixqA:
undetectable
6dlzC-5ixqA:
undetectable
6dlzB-5ixqA:
8.44
6dlzC-5ixqA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
5 / 11 ILE A 447
PRO A 468
SER A 494
LEU A 456
LEU A 501
None
1.26A 6dlzA-5ixqA:
undetectable
6dlzD-5ixqA:
undetectable
6dlzA-5ixqA:
8.44
6dlzD-5ixqA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
5 / 10 SER A 494
LEU A 456
LEU A 501
ILE A 447
PRO A 468
None
1.25A 6dm0B-5ixqA:
undetectable
6dm0C-5ixqA:
undetectable
6dm0B-5ixqA:
8.44
6dm0C-5ixqA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
5 / 10 SER A 494
LEU A 456
LEU A 501
ILE A 447
PRO A 468
None
1.25A 6dm1B-5ixqA:
undetectable
6dm1C-5ixqA:
undetectable
6dm1B-5ixqA:
8.44
6dm1C-5ixqA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
5 / 11 ILE A 447
PRO A 468
SER A 494
LEU A 456
LEU A 501
None
1.25A 6dm1A-5ixqA:
undetectable
6dm1D-5ixqA:
undetectable
6dm1A-5ixqA:
8.44
6dm1D-5ixqA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
5 / 10 SER A 494
LEU A 456
LEU A 501
ILE A 447
PRO A 468
None
1.18A 6dm2B-5ixqA:
undetectable
6dm2C-5ixqA:
undetectable
6dm2B-5ixqA:
8.44
6dm2C-5ixqA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
5 / 10 ILE A 447
PRO A 468
SER A 494
LEU A 456
LEU A 501
None
1.18A 6dm2A-5ixqA:
undetectable
6dm2D-5ixqA:
undetectable
6dm2A-5ixqA:
8.44
6dm2D-5ixqA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
5 / 12 LEU A 338
ALA A 291
LEU A 306
MET A 283
LEU A 276
None
1.27A 6ie8A-5ixqA:
undetectable
6ie8A-5ixqA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana)
5 / 12 LEU A 338
ILE A 327
ALA A 291
LEU A 306
LEU A 276
None
0.93A 6ie8A-5ixqA:
undetectable
6ie8A-5ixqA:
13.87