SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ixx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 5ixx ALR2278 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 6 HIS A  16
ALA A  69
GLY A  71
TYR A  73
 MLI  A 203 (-3.1A)
MLI  A 203 ( 3.7A)
None
None
 1.09A 1gfzA-5ixxA:
undetectable		 1gfzA-5ixxA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 5ixx ALR2278 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 6 LEU A 141
MET A 144
LEU A 148
MET A   1
 HEM  A 201 ( 4.7A)
6EX  A 202 ( 3.6A)
HEM  A 201 ( 3.4A)
6EX  A 202 (-4.2A)
 1.08A 2kuhA-5ixxA:
undetectable		 2kuhA-5ixxA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 5ixx ALR2278 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 VAL A   5
ALA A   8
VAL A 108
VAL A  52
THR A  48
 6EX  A 202 (-4.0A)
None
HEM  A 201 ( 4.7A)
None
None
 1.13A 3czhA-5ixxA:
undetectable		 3czhA-5ixxA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 5ixx ALR2278 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 VAL A   5
ALA A   8
VAL A 108
VAL A  52
THR A  48
 6EX  A 202 (-4.0A)
None
HEM  A 201 ( 4.7A)
None
None
 1.13A 3dl9A-5ixxA:
undetectable		 3dl9A-5ixxA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 5ixx ALR2278 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 7 LEU A 101
LEU A 148
ILE A 179
VAL A 162
 HEM  A 201 (-4.8A)
HEM  A 201 ( 3.4A)
None
None
 0.80A 4ojbA-5ixxA:
undetectable		 4ojbA-5ixxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5ixx ALR2278 PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU A 152
ASP A  92
GLY A  91
ASN A 100
LEU A 104
 None
 1.33A 5kc4E-5ixxA:
undetectable		 5kc4E-5ixxA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5ixx ALR2278 PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 5 ALA A   8
TYR A  73
GLN A  10
ILE A  13
 None
 1.18A 6f6sA-5ixxA:
undetectable
6f6sB-5ixxA:
undetectable		 6f6sA-5ixxA:
15.34
6f6sB-5ixxA:
23.72