SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iy6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5iy6 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT
(Homo
sapiens) 		4 / 8 MET V 536
PHE V 541
ALA V 572
LEU V 575
 None
 1.08A 2o01A-5iy6V:
undetectable		 2o01A-5iy6V:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5iy6 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT
(Homo
sapiens) 		5 / 12 GLU V 619
VAL V 560
ASP V 556
ILE V 558
ASN V 603
 None
 1.25A 3jayA-5iy6V:
undetectable		 3jayA-5iy6V:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5iy6 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT
(Homo
sapiens) 		4 / 7 LEU V 455
LEU V 364
SER V 411
THR V 393
 None
 0.52A 3lm8B-5iy6V:
undetectable
3lm8D-5iy6V:
undetectable		 3lm8B-5iy6V:
14.73
3lm8D-5iy6V:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 5iy6 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT
(Homo
sapiens) 		4 / 6 VAL V 505
ASN V 656
TYR V 685
ILE V 502
 None
 1.15A 3q5sA-5iy6V:
undetectable		 3q5sA-5iy6V:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5iy6 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT
(Homo
sapiens) 		5 / 12 ILE V 439
LEU V 440
VAL V 458
ALA V 460
LEU V 437
 None
 1.28A 4m11C-5iy6V:
undetectable		 4m11C-5iy6V:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 5iy6 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT
(Homo
sapiens) 		4 / 4 THR V 469
GLY V 630
ASP V 563
SER V 632
 None
 1.39A 4rfqA-5iy6V:
2.7		 4rfqA-5iy6V:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5iy6 GENERAL
TRANSCRIPTION FACTOR
IIF SUBUNIT 2
(Homo
sapiens) 		5 / 11 LEU T 199
GLU T 219
LYS T 218
LEU T 217
LEU T 213
 None
 1.10A 4wg0F-5iy6T:
undetectable
4wg0G-5iy6T:
undetectable
4wg0H-5iy6T:
undetectable		 4wg0F-5iy6T:
5.78
4wg0G-5iy6T:
5.78
4wg0H-5iy6T:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5iy6 GENERAL
TRANSCRIPTION FACTOR
IIF SUBUNIT 2
(Homo
sapiens) 		5 / 11 LEU T 199
GLU T 219
LYS T 218
LEU T 217
LEU T 213
 None
 1.16A 4wg0H-5iy6T:
undetectable
4wg0I-5iy6T:
undetectable
4wg0J-5iy6T:
undetectable		 4wg0H-5iy6T:
5.78
4wg0I-5iy6T:
5.78
4wg0J-5iy6T:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5iy6 GENERAL
TRANSCRIPTION FACTOR
IIF SUBUNIT 2
(Homo
sapiens) 		5 / 11 LEU T 213
GLU T 219
LYS T 218
LEU T 217
LEU T 199
 None
 1.08A 4wg0G-5iy6T:
undetectable
4wg0H-5iy6T:
undetectable
4wg0I-5iy6T:
undetectable		 4wg0G-5iy6T:
5.78
4wg0H-5iy6T:
5.78
4wg0I-5iy6T:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5iy6 GENERAL
TRANSCRIPTION FACTOR
IIF SUBUNIT 2
(Homo
sapiens) 		5 / 10 GLY T  11
GLU T 107
THR T  94
SER T 105
LEU T   7
 None
 1.31A 4yb6C-5iy6T:
undetectable
4yb6F-5iy6T:
undetectable		 4yb6C-5iy6T:
23.27
4yb6F-5iy6T:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5iy6 GENERAL
TRANSCRIPTION FACTOR
IIF SUBUNIT 2
(Homo
sapiens) 		5 / 10 SER T 105
LEU T   7
GLY T  11
GLU T 107
THR T  94
 None
 1.32A 4yb6A-5iy6T:
undetectable
4yb6D-5iy6T:
undetectable		 4yb6A-5iy6T:
23.27
4yb6D-5iy6T:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5iy6 GENERAL
TRANSCRIPTION FACTOR
IIF SUBUNIT 2
(Homo
sapiens) 		5 / 10 SER T 105
LEU T   7
GLY T  11
GLU T 107
THR T  94
 None
 1.31A 4yb6D-5iy6T:
undetectable
4yb6E-5iy6T:
undetectable		 4yb6D-5iy6T:
23.27
4yb6E-5iy6T:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5iy6 GENERAL
TRANSCRIPTION FACTOR
IIF SUBUNIT 2
(Homo
sapiens) 		5 / 10 SER T 105
LEU T   7
GLY T  11
GLU T 107
THR T  94
 None
 1.30A 4yb6B-5iy6T:
undetectable
4yb6F-5iy6T:
undetectable		 4yb6B-5iy6T:
23.27
4yb6F-5iy6T:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 5iy6 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT
(Homo
sapiens) 		4 / 8 ASN V 539
PRO V 538
PHE V 703
SER V 704
 None
 1.45A 5amiB-5iy6V:
undetectable		 5amiB-5iy6V:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5iy6 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT
(Homo
sapiens) 		5 / 12 ALA V 562
GLY V 630
SER V 627
GLU V 669
TYR V 672
 None
 1.32A 5hfjA-5iy6V:
2.1		 5hfjA-5iy6V:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5iy6 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT
(Homo
sapiens) 		5 / 12 ALA V 562
GLY V 630
SER V 627
GLU V 669
TYR V 672
 None
 1.33A 5hfjC-5iy6V:
2.4		 5hfjC-5iy6V:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5iy6 GENERAL
TRANSCRIPTION FACTOR
IIF SUBUNIT 2
(Homo
sapiens) 		4 / 6 PHE T  83
PRO T  82
ARG T  44
THR T  57
 None
 1.46A 5ih0A-5iy6T:
undetectable		 5ih0A-5iy6T:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5iy6 TRANSCRIPTION
ELONGATION FACTOR A
PROTEIN 1
(Homo
sapiens) 		4 / 6 ASP U 200
ARG U 190
ASN U 189
ASN U 197
 None
 0.97A 5l6eA-5iy6U:
undetectable		 5l6eA-5iy6U:
18.87