SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iy7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 5iy7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB10
(Homo
sapiens) 		3 / 3 CYH J  44
ARG J  47
CYH J   7
 None
 1.29A 1p9gA-5iy7J:
undetectable		 1p9gA-5iy7J:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 5iy7 TATA-BOX-BINDING
PROTEIN
TRANSCRIPTION
INITIATION FACTOR
IIB
(Homo
sapiens) 		4 / 7 ILE M 166
ARG M 169
PHE M 177
GLU P 284
 None
 1.12A 2qebA-5iy7M:
undetectable		 2qebA-5iy7M:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5iy7 TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA
(Homo
sapiens) 		5 / 12 GLU R 131
PHE R 139
ARG R 146
ALA R 174
LEU R 151
 None
 1.32A 2xkwB-5iy7R:
undetectable		 2xkwB-5iy7R:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 5iy7 TRANSCRIPTION
INITIATION FACTOR
IIB
(Homo
sapiens) 		3 / 3 LEU M 291
ARG M 290
ILE M 292
 None
 0.69A 2xn5B-5iy7M:
undetectable		 2xn5B-5iy7M:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 5iy7 GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1
(Homo
sapiens) 		5 / 12 VAL Q  21
GLY Q  27
TYR Q  20
GLN Q  58
HIS Q  30
 None
 1.48A 3bwmA-5iy7Q:
undetectable		 3bwmA-5iy7Q:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5iy7 TATA-BOX-BINDING
PROTEIN
(Homo
sapiens) 		4 / 7 THR P 210
VAL P 220
THR P 222
VAL P 169
 None
 0.58A 3em0B-5iy7P:
undetectable		 3em0B-5iy7P:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 5iy7 TRANSCRIPTION
INITIATION FACTOR
IIB
(Homo
sapiens) 		4 / 5 SER M 216
ARG M 217
ARG M 169
GLY M 172
 None
 1.22A 3k9fA-5iy7M:
undetectable
3k9fB-5iy7M:
undetectable
3k9fC-5iy7M:
undetectable		 3k9fA-5iy7M:
21.62
3k9fB-5iy7M:
21.62
3k9fC-5iy7M:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 5iy7 GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE Q  38
THR Q  98
LEU Q  66
VAL Q  21
ILE Q  22
 None
 1.06A 4c9lA-5iy7Q:
undetectable		 4c9lA-5iy7Q:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 5iy7 GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE Q  38
THR Q  98
LEU Q  66
VAL Q  21
ILE Q  22
 None
 1.05A 4c9lB-5iy7Q:
undetectable		 4c9lB-5iy7Q:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 5iy7 GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE Q  38
THR Q  98
LEU Q  66
VAL Q  21
ILE Q  22
 None
 1.06A 4c9oA-5iy7Q:
undetectable		 4c9oA-5iy7Q:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 5iy7 GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE Q  38
THR Q  98
LEU Q  66
VAL Q  21
ILE Q  22
 None
 1.05A 4c9oB-5iy7Q:
undetectable		 4c9oB-5iy7Q:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 5iy7 TRANSCRIPTION
INITIATION FACTOR
IIB
(Homo
sapiens) 		4 / 7 ALA M 256
ALA M 278
GLY M 275
ILE M 251
 None
 0.65A 4eatA-5iy7M:
undetectable		 4eatA-5iy7M:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5iy7 TATA-BOX-BINDING
PROTEIN
(Homo
sapiens) 		5 / 11 VAL P 240
ALA P 187
PHE P 214
LEU P 174
VAL P 241
 None
 1.20A 4eilC-5iy7P:
undetectable		 4eilC-5iy7P:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5iy7 TATA-BOX-BINDING
PROTEIN
(Homo
sapiens) 		5 / 11 VAL P 240
ALA P 187
PHE P 214
LEU P 174
VAL P 241
 None
 1.23A 4eilE-5iy7P:
undetectable		 4eilE-5iy7P:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 5iy7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB12
(Homo
sapiens) 		3 / 3 ARG L  37
GLU L  27
ASN L  26
 None
 0.90A 4imaD-5iy7L:
undetectable		 4imaD-5iy7L:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 5iy7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB12
(Homo
sapiens) 		3 / 3 ARG L  37
GLU L  27
ASN L  26
 None
 0.91A 4ip7D-5iy7L:
undetectable		 4ip7D-5iy7L:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 5iy7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB10
(Homo
sapiens) 		4 / 5 LYS J  41
LEU J  40
LEU J  38
LYS J  17
 None
 1.36A 4k4yI-5iy7J:
undetectable		 4k4yI-5iy7J:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 5iy7 TRANSCRIPTION
INITIATION FACTOR
IIB
(Homo
sapiens) 		5 / 12 ILE M 235
ALA M 256
ILE M 274
GLN M 263
LEU M 224
 None
 1.08A 4m2xG-5iy7M:
undetectable		 4m2xG-5iy7M:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5iy7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB11-A
(Homo
sapiens) 		4 / 6 ASN K  36
GLU K  68
GLU K   8
GLU K  16
 None
 1.29A 4mi4A-5iy7K:
undetectable		 4mi4A-5iy7K:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5iy7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB11-A
(Homo
sapiens) 		4 / 7 ASN K  36
GLU K  68
GLU K   8
GLU K  16
 None
 1.29A 4mi4A-5iy7K:
undetectable
4mi4C-5iy7K:
undetectable		 4mi4A-5iy7K:
19.90
4mi4C-5iy7K:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5iy7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB11-A
(Homo
sapiens) 		4 / 7 ASN K  36
GLU K  68
GLU K   8
GLU K  16
 None
 1.29A 4mj8C-5iy7K:
undetectable		 4mj8C-5iy7K:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 5iy7 GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1
(Homo
sapiens) 		5 / 12 ASP Q  35
LEU Q  32
LEU Q  52
LEU Q  37
ILE Q  36
 None
 1.10A 4x1fA-5iy7Q:
undetectable		 4x1fA-5iy7Q:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5iy7 GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1
(Homo
sapiens) 		5 / 12 VAL Q  21
GLY Q  27
TYR Q  20
GLN Q  58
HIS Q  30
 None
 1.47A 4xudA-5iy7Q:
undetectable		 4xudA-5iy7Q:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5iy7 TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 1
TATA-BOX-BINDING
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP N 322
LEU P 244
ARG P 186
 None
 0.87A 5e8qA-5iy7N:
undetectable		 5e8qA-5iy7N:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 5iy7 GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU Q  63
ASN Q  64
LEU Q  66
GLY Q  68
LEU Q  37
 None
 1.12A 5uc1B-5iy7Q:
undetectable		 5uc1B-5iy7Q:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5iy7 TATA-BOX-BINDING
PROTEIN
(Homo
sapiens) 		5 / 12 ALA P 238
PRO P 247
GLY P 245
ALA P 234
ARG P 231
 None
 1.19A 5zvgA-5iy7P:
undetectable		 5zvgA-5iy7P:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5iy7 TATA-BOX-BINDING
PROTEIN
(Homo
sapiens) 		5 / 12 ALA P 238
PRO P 247
GLY P 245
ALA P 234
ARG P 231
 None
 1.20A 5zvgB-5iy7P:
undetectable		 5zvgB-5iy7P:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5iy7 TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA
(Homo
sapiens) 		5 / 9 LEU R  97
THR R  98
GLY R 135
ILE R 133
ILE R 130
 None
 1.04A 6ebpA-5iy7R:
undetectable		 6ebpA-5iy7R:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5iy7 TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA
(Homo
sapiens) 		5 / 10 LEU R  97
THR R  98
GLY R 135
ILE R 133
ILE R 130
 None
 1.07A 6ebpB-5iy7R:
undetectable		 6ebpB-5iy7R:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5iy7 TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA
(Homo
sapiens) 		5 / 10 LEU R  97
THR R  98
GLY R 135
ILE R 133
ILE R 130
 None
 1.07A 6ebpC-5iy7R:
undetectable		 6ebpC-5iy7R:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5iy7 TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA
(Homo
sapiens) 		5 / 10 LEU R  97
THR R  98
GLY R 135
ILE R 133
ILE R 130
 None
 1.08A 6ebpD-5iy7R:
undetectable		 6ebpD-5iy7R:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5iy7 TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA
(Homo
sapiens) 		5 / 11 LEU R  97
THR R  98
GLY R 135
ILE R 133
ILE R 130
 None
 1.07A 6ebzB-5iy7R:
undetectable		 6ebzB-5iy7R:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 5iy7 TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA
(Homo
sapiens) 		5 / 11 LEU R  97
THR R  98
GLY R 135
ILE R 133
ILE R 130
 None
 1.07A 6gp2B-5iy7R:
undetectable		 6gp2B-5iy7R:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5iy7 GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1
(Homo
sapiens) 		3 / 3 THR Q 137
GLU Q 165
ASN Q 123
 None
 0.54A 6nj9K-5iy7Q:
undetectable		 6nj9K-5iy7Q:
20.91