SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iy9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB4
(Homo
sapiens) 		5 / 10 ALA D  17
LEU D  20
GLU D  96
LEU D 118
GLU D 110
 None
 1.48A 1a29A-5iy9D:
undetectable		 1a29A-5iy9D:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB7
(Homo
sapiens) 		5 / 11 ALA G  87
THR G  99
ILE G 108
LEU G 168
GLY G 169
 None
 0.85A 1b02A-5iy9G:
undetectable		 1b02A-5iy9G:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 12 ILE A 595
PHE A 592
THR A 541
LEU A 645
ILE A 672
 None
 1.05A 1cd2A-5iy9A:
undetectable		 1cd2A-5iy9A:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 12 LEU A 645
LEU A 652
VAL A 653
SER A 656
VAL A 545
 None
 1.17A 1db1A-5iy9A:
undetectable		 1db1A-5iy9A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		4 / 6 LEU A 276
ASP A 282
MET A  58
LEU A 258
 None
 0.90A 1errB-5iy9A:
undetectable		 1errB-5iy9A:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 10 LEU A 640
LEU A 635
ILE A 591
THR A 541
ILE A 676
 None
 1.29A 1i18A-5iy9A:
undetectable
1i18B-5iy9A:
undetectable		 1i18A-5iy9A:
4.69
1i18B-5iy9A:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 10 THR A 541
ILE A 676
LEU A 640
LEU A 635
ILE A 591
 None
 1.28A 1i18A-5iy9A:
undetectable
1i18B-5iy9A:
undetectable		 1i18A-5iy9A:
4.69
1i18B-5iy9A:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 12 LEU A 645
LEU A 652
VAL A 653
SER A 656
VAL A 545
 None
 1.30A 1ie9A-5iy9A:
undetectable		 1ie9A-5iy9A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB4
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB7
(Homo
sapiens;
Homo
sapiens) 		5 / 12 PHE D  26
THR G  37
THR G  39
LEU G   7
ILE G   5
 None
 1.24A 1kqwA-5iy9D:
undetectable		 1kqwA-5iy9D:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB6
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB7
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ILE F 102
PRO F 103
GLU F  96
PHE G  18
 None
 1.14A 1oniA-5iy9F:
undetectable
1oniC-5iy9F:
undetectable		 1oniA-5iy9F:
19.35
1oniC-5iy9F:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB6
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB7
(Homo
sapiens;
Homo
sapiens) 		4 / 7 ILE F 102
PRO F 103
GLU F  96
PHE G  18
 None
 1.15A 1oniD-5iy9F:
undetectable
1oniE-5iy9F:
undetectable		 1oniD-5iy9F:
19.35
1oniE-5iy9F:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		3 / 3 GLU A 631
ASN A 601
TRP A 988
 None
 1.13A 1r15D-5iy9A:
undetectable		 1r15D-5iy9A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		3 / 3 GLU A 631
ASN A 601
TRP A 988
 None
 1.17A 1r15E-5iy9A:
undetectable		 1r15E-5iy9A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		3 / 3 GLU A 631
ASN A 601
TRP A 988
 None
 1.19A 1r15F-5iy9A:
undetectable		 1r15F-5iy9A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		4 / 7 LEU A 680
MET A 769
VAL A 770
SER A 772
 None
 1.11A 1wrlA-5iy9A:
undetectable
1wrlB-5iy9A:
undetectable		 1wrlA-5iy9A:
3.46
1wrlB-5iy9A:
3.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		4 / 5 LEU A 276
ASP A 282
MET A  58
LEU A 258
 None
 0.92A 2jfaA-5iy9A:
undetectable		 2jfaA-5iy9A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		3 / 3 VAL A1010
GLU A 951
GLU A1011
 None
 0.72A 2nv4A-5iy9A:
undetectable		 2nv4A-5iy9A:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		4 / 5 LEU A 325
VAL A1438
LEU A1439
ARG A 351
 None
 0.98A 2oiqA-5iy9A:
3.0		 2oiqA-5iy9A:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		4 / 5 LEU A 276
ASP A 282
MET A  58
LEU A 258
 None
 0.91A 2qxsA-5iy9A:
undetectable		 2qxsA-5iy9A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		4 / 5 LEU A 276
ASP A 282
MET A  58
LEU A 258
 None
 0.90A 2qxsB-5iy9A:
undetectable		 2qxsB-5iy9A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB6
(Homo
sapiens) 		4 / 6 LEU F  90
LEU F  91
ASP F  88
ILE A 455
 None
 1.10A 2rlfB-5iy9F:
undetectable
2rlfC-5iy9F:
undetectable		 2rlfB-5iy9F:
16.13
2rlfC-5iy9F:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 11 VAL A 873
GLY A1084
ILE A1080
GLU A1085
ALA A1081
 None
 1.16A 2yy8A-5iy9A:
undetectable
2yy8B-5iy9A:
undetectable		 2yy8A-5iy9A:
8.35
2yy8B-5iy9A:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 12 VAL A 526
GLU A 902
TYR A 657
ASN A 601
ARG A 604
 None
 1.42A 2zvjA-5iy9A:
undetectable		 2zvjA-5iy9A:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_0
(CATECHOL
O-METHYLTRANSFERASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 12 VAL A 526
GLU A 902
TYR A 657
ASN A 601
ARG A 604
 None
 1.36A 3a7eA-5iy9A:
0.0		 3a7eA-5iy9A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 11 LEU A1143
ALA A1151
ALA A1154
VAL A1352
LEU A1161
 None
 0.95A 3bszE-5iy9A:
undetectable		 3bszE-5iy9A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 12 LEU A1124
LEU A1127
LEU A1411
LEU A1401
MET A1405
 None
 1.26A 3d90B-5iy9A:
undetectable		 3d90B-5iy9A:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB6
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB7
(Homo
sapiens) 		5 / 9 ASP F 117
ASP A1472
ILE G  59
GLY G  57
ILE F 105
 None
 1.06A 3ekyB-5iy9F:
undetectable		 3ekyB-5iy9F:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB6
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB7
(Homo
sapiens) 		5 / 10 ASP F 117
ASP A1472
ILE G  59
GLY G  57
ILE F 105
 None
 1.06A 3em4V-5iy9F:
undetectable		 3em4V-5iy9F:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 10 GLY A1088
HIS A1397
VAL A 873
VAL A 879
GLN A 888
 None
 1.03A 3fhjA-5iy9A:
undetectable		 3fhjA-5iy9A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 10 GLY A1088
HIS A1397
VAL A 873
VAL A 879
GLN A 888
 None
 1.03A 3fhjB-5iy9A:
undetectable		 3fhjB-5iy9A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 10 GLY A1088
HIS A1397
VAL A 873
VAL A 879
GLN A 888
 None
 1.03A 3fhjC-5iy9A:
undetectable		 3fhjC-5iy9A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 9 GLY A1088
HIS A1397
VAL A 873
VAL A 879
GLN A 888
 None
 1.03A 3fhjD-5iy9A:
undetectable		 3fhjD-5iy9A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 10 GLY A1088
HIS A1397
VAL A 873
VAL A 879
GLN A 888
 None
 1.03A 3fhjE-5iy9A:
2.9		 3fhjE-5iy9A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 9 GLY A1088
HIS A1397
VAL A 873
VAL A 879
GLN A 888
 None
 1.03A 3fhjF-5iy9A:
undetectable		 3fhjF-5iy9A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 9 GLY A1088
HIS A1397
VAL A 873
VAL A 879
GLN A 888
 None
 0.97A 3fi0A-5iy9A:
undetectable		 3fi0A-5iy9A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 9 GLY A1088
HIS A1397
VAL A 873
VAL A 879
GLN A 888
 None
 0.97A 3fi0C-5iy9A:
undetectable		 3fi0C-5iy9A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 9 GLY A1088
HIS A1397
VAL A 873
VAL A 879
GLN A 888
 None
 0.95A 3fi0D-5iy9A:
undetectable		 3fi0D-5iy9A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		4 / 7 GLY A1088
HIS A1397
VAL A 873
GLN A 888
 None
 0.89A 3fi0E-5iy9A:
undetectable		 3fi0E-5iy9A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 9 GLY A1088
HIS A1397
VAL A 873
VAL A 879
GLN A 888
 None
 0.97A 3fi0F-5iy9A:
undetectable		 3fi0F-5iy9A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 9 GLY A1088
HIS A1397
VAL A 873
VAL A 879
GLN A 888
 None
 1.00A 3fi0H-5iy9A:
undetectable		 3fi0H-5iy9A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 9 GLY A1088
HIS A1397
VAL A 873
VAL A 879
GLN A 888
 None
 0.96A 3fi0J-5iy9A:
undetectable		 3fi0J-5iy9A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 9 GLY A1088
HIS A1397
VAL A 873
VAL A 879
GLN A 888
 None
 0.95A 3fi0K-5iy9A:
undetectable		 3fi0K-5iy9A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 9 GLY A1088
HIS A1397
VAL A 873
VAL A 879
GLN A 888
 None
 1.05A 3fi0L-5iy9A:
undetectable		 3fi0L-5iy9A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 9 GLY A1088
HIS A1397
VAL A 873
VAL A 879
GLN A 888
 None
 1.02A 3fi0M-5iy9A:
undetectable		 3fi0M-5iy9A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 9 GLY A1088
HIS A1397
VAL A 873
VAL A 879
GLN A 888
 None
 0.94A 3fi0N-5iy9A:
2.5		 3fi0N-5iy9A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 9 GLY A1088
HIS A1397
VAL A 873
VAL A 879
GLN A 888
 None
 1.03A 3fi0O-5iy9A:
undetectable		 3fi0O-5iy9A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 9 GLY A1088
HIS A1397
VAL A 873
VAL A 879
GLN A 888
 None
 1.04A 3fi0R-5iy9A:
undetectable		 3fi0R-5iy9A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 12 LEU A1343
GLY A1340
ILE A1365
SER A1359
ARG A1123
 None
 1.07A 3gyqA-5iy9A:
undetectable
3gyqB-5iy9A:
undetectable		 3gyqA-5iy9A:
11.75
3gyqB-5iy9A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		3 / 3 ASN A 982
ASN A 989
GLU A 659
 None
 0.93A 3kpdB-5iy9A:
undetectable		 3kpdB-5iy9A:
4.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 5iy9 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		5 / 12 THR 2 133
GLY 2 165
SER 2  86
HIS 2  97
SER 2 172
 None
 1.19A 3mg02-5iy92:
undetectable
3mg0V-5iy92:
undetectable		 3mg02-5iy92:
17.24
3mg0V-5iy92:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB6
(Homo
sapiens) 		4 / 5 ILE F 124
ARG F 108
THR F  54
GLU F  61
 None
 1.46A 3ny4A-5iy9F:
undetectable		 3ny4A-5iy9F:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB9
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS A1306
ARG A1224
LYS I  57
 None
 1.45A 3okxA-5iy9A:
undetectable		 3okxA-5iy9A:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		4 / 8 VAL A 545
LEU A 640
LEU A 645
ILE A 595
 None
 0.91A 3u5kA-5iy9A:
undetectable		 3u5kA-5iy9A:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		4 / 7 VAL A 545
LEU A 640
LEU A 645
ILE A 595
 None
 0.93A 3u5kB-5iy9A:
undetectable		 3u5kB-5iy9A:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 12 LEU A1216
LEU A1166
MET A1296
ILE A1259
ILE A1235
 None
 1.13A 3ut5B-5iy9A:
undetectable		 3ut5B-5iy9A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		4 / 5 VAL A 545
LEU A 640
LEU A 645
ILE A 595
 None
 0.91A 4a9jB-5iy9A:
undetectable		 4a9jB-5iy9A:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		4 / 5 VAL A 545
LEU A 640
LEU A 645
ILE A 595
 None
 0.93A 4a9jC-5iy9A:
undetectable		 4a9jC-5iy9A:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 5iy9 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 GLN 2 181
ASP 2 174
GLN 2 173
 None
 0.81A 4aztA-5iy92:
undetectable		 4aztA-5iy92:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 5iy9 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 4
(Homo
sapiens) 		3 / 3 GLN 2 239
ASP 2 207
GLN 2 202
 None
 0.73A 4aztA-5iy92:
undetectable		 4aztA-5iy92:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		4 / 7 SER A1147
ARG A1153
GLU A1349
ILE A1157
 None
 1.13A 4d33B-5iy9A:
undetectable		 4d33B-5iy9A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 12 VAL A 521
ALA A 519
MET A 501
PHE A 482
LEU A 484
 None
 1.15A 4eckA-5iy9A:
undetectable		 4eckA-5iy9A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		4 / 6 LEU A 310
LYS A  92
LEU A 290
GLU A 294
 None
 1.08A 4f3tA-5iy9A:
undetectable		 4f3tA-5iy9A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB8
(Homo
sapiens) 		4 / 8 TYR H  90
VAL H  50
TYR H  48
LEU H  58
 None
 1.09A 4jtrA-5iy9H:
undetectable		 4jtrA-5iy9H:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 12 ILE A 595
PHE A 592
THR A 541
LEU A 645
ILE A 672
 None
 1.04A 4kjkA-5iy9A:
undetectable		 4kjkA-5iy9A:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 12 ALA A1377
LEU A1127
SER A1387
ILE A1386
LEU A1095
 None
 1.05A 4ky8C-5iy9A:
undetectable		 4ky8C-5iy9A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB4
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB7
(Homo
sapiens;
Homo
sapiens) 		3 / 3 GLU D 110
ARG G 144
GLN D 135
 None
 0.88A 4rtbA-5iy9D:
undetectable		 4rtbA-5iy9D:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		4 / 5 ILE A 419
VAL A 446
PHE A 397
HIS A 432
 None
 0.88A 4rzvA-5iy9A:
1.2		 4rzvA-5iy9A:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 12 ASN A 945
SER A 944
ARG A 932
PRO A1006
ILE A1007
 None
 0.98A 4uroB-5iy9A:
undetectable		 4uroB-5iy9A:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 12 LEU A  57
GLU A  38
GLY A  39
GLY A  55
GLY A  56
 None
 1.05A 4yvgA-5iy9A:
undetectable		 4yvgA-5iy9A:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		4 / 5 ARG A1153
GLN A1146
ILE A1157
ASP A1351
 None
 1.29A 4z4hA-5iy9A:
2.8		 4z4hA-5iy9A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		3 / 3 THR A 316
ALA A 328
ASN A 320
 None
 0.63A 5ersA-5iy9A:
undetectable		 5ersA-5iy9A:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHQ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 12 VAL A 526
GLU A 902
TYR A 657
ASN A 601
ARG A 604
 None
 1.40A 5fhqA-5iy9A:
undetectable		 5fhqA-5iy9A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		4 / 6 PHE A 800
GLU A 738
PHE A 737
VAL A 713
 None
 1.30A 5h4dA-5iy9A:
undetectable		 5h4dA-5iy9A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		4 / 8 LEU A1095
LEU A1127
GLN A1422
MET A 868
 None
 1.19A 5hbsA-5iy9A:
undetectable		 5hbsA-5iy9A:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 12 ILE A1362
ILE A1414
LEU A 864
GLY A1096
PRO A1098
 None
 1.15A 5ienA-5iy9A:
undetectable		 5ienA-5iy9A:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 12 ASN A 905
ASN A 982
THR A 605
SER A 651
GLY A 650
 None
 1.47A 5oj0A-5iy9A:
undetectable		 5oj0A-5iy9A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB7
(Homo
sapiens) 		5 / 9 VAL G  26
LEU G  22
PHE G  18
VAL G  66
HIS G  14
 None
 1.17A 5om2A-5iy9G:
undetectable
5om2B-5iy9G:
undetectable		 5om2A-5iy9G:
18.75
5om2B-5iy9G:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB6
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB7
(Homo
sapiens) 		4 / 8 ILE F  92
PHE A 397
ASN A 398
PRO G  15
 None
 1.05A 5x23A-5iy9F:
undetectable		 5x23A-5iy9F:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		5 / 12 ALA A1091
VAL A 871
VAL A 887
ASP A1403
LEU A1378
 None
 1.21A 5x24A-5iy9A:
undetectable		 5x24A-5iy9A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		4 / 5 ARG A1408
MET A1405
THR A1404
LEU A1401
 None
 1.30A 5z86J-5iy9A:
undetectable		 5z86J-5iy9A:
2.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		4 / 5 GLN A  62
VAL A  64
PRO A 257
THR A  79
 None
 1.48A 6cduI-5iy9A:
3.8
6cduJ-5iy9A:
3.2		 6cduI-5iy9A:
9.28
6cduJ-5iy9A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		4 / 7 ASP A1249
ASN A1251
ALA A1252
GLU A1188
 None
 1.08A 6ci6A-5iy9A:
2.1		 6ci6A-5iy9A:
3.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		4 / 7 LEU A1211
ASP A1178
ARG A1260
GLN A1190
 None
 1.20A 6g31D-5iy9A:
5.1		 6g31D-5iy9A:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		4 / 6 LEU A1211
ASP A1178
ARG A1260
GLN A1190
 None
 1.16A 6g31J-5iy9A:
2.9		 6g31J-5iy9A:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB9
(Homo
sapiens) 		4 / 8 ILE I  14
ARG I  15
ASN I  22
TYR I  44
 None
 1.23A 6hisA-5iy9I:
undetectable
6hisB-5iy9I:
undetectable		 6hisA-5iy9I:
14.40
6hisB-5iy9I:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB9
(Homo
sapiens) 		4 / 8 ILE I  14
ARG I  15
ASN I  22
TYR I  44
 None
 1.24A 6hisD-5iy9I:
undetectable
6hisE-5iy9I:
undetectable		 6hisD-5iy9I:
14.40
6hisE-5iy9I:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens) 		4 / 5 ARG A1408
MET A1405
THR A1404
LEU A1401
 None
 1.38A 6nknW-5iy9A:
undetectable		 6nknW-5iy9A:
2.72