SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iys'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
3 / 3 LEU A  32
HIS A 272
LYS A 275
None
1.09A 1y7iA-5iysA:
undetectable
1y7iA-5iysA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
4 / 8 ALA A  50
PHE A  51
ALA A  55
LEU A 110
None
0.85A 2bxmA-5iysA:
undetectable
2bxmA-5iysA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
5 / 10 ALA A  50
PHE A  51
ALA A  55
LEU A  68
LEU A 110
None
1.12A 2bxqA-5iysA:
2.8
2bxqA-5iysA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
5 / 9 ASP A  56
ASP A  60
GLN A 113
GLN A 166
ASN A 169
MG  A 505 (-2.5A)
MG  A 504 (-2.5A)
MG  A 504 (-3.9A)
FPS  A 507 (-3.9A)
MG  A 503 (-2.9A)
0.63A 2o1oA-5iysA:
5.7
2o1oA-5iysA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
5 / 10 ASP A  56
ASP A  60
ARG A  53
GLN A 166
ASN A 169
MG  A 505 (-2.5A)
MG  A 504 (-2.5A)
FPS  A 506 ( 3.1A)
FPS  A 507 (-3.9A)
MG  A 503 (-2.9A)
0.95A 2o1oB-5iysA:
5.4
2o1oB-5iysA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
5 / 10 ASP A  56
ASP A  60
GLN A 113
GLN A 166
ASN A 169
MG  A 505 (-2.5A)
MG  A 504 (-2.5A)
MG  A 504 (-3.9A)
FPS  A 507 (-3.9A)
MG  A 503 (-2.9A)
0.66A 2o1oB-5iysA:
5.4
2o1oB-5iysA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
5 / 10 ASP A  56
ASP A  60
ARG A  53
GLN A 166
ASN A 169
MG  A 505 (-2.5A)
MG  A 504 (-2.5A)
FPS  A 506 ( 3.1A)
FPS  A 507 (-3.9A)
MG  A 503 (-2.9A)
0.85A 2q58A-5iysA:
7.1
2q58A-5iysA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
5 / 10 ASP A  56
ASP A  60
GLN A 113
GLN A 166
ASN A 169
MG  A 505 (-2.5A)
MG  A 504 (-2.5A)
MG  A 504 (-3.9A)
FPS  A 507 (-3.9A)
MG  A 503 (-2.9A)
0.69A 2q58A-5iysA:
7.1
2q58A-5iysA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
5 / 9 ASP A  56
ASP A  60
ARG A  53
GLN A 166
ASN A 169
MG  A 505 (-2.5A)
MG  A 504 (-2.5A)
FPS  A 506 ( 3.1A)
FPS  A 507 (-3.9A)
MG  A 503 (-2.9A)
1.02A 2q58B-5iysA:
8.3
2q58B-5iysA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
5 / 9 ASP A  56
ASP A  60
GLN A 113
GLN A 166
ASN A 169
MG  A 505 (-2.5A)
MG  A 504 (-2.5A)
MG  A 504 (-3.9A)
FPS  A 507 (-3.9A)
MG  A 503 (-2.9A)
0.72A 2q58B-5iysA:
8.3
2q58B-5iysA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
5 / 12 TYR A 224
GLY A 137
SER A 138
VAL A 139
TYR A 249
None
None
None
FPS  A 506 (-4.3A)
FPS  A 506 (-4.2A)
1.39A 3hiiA-5iysA:
undetectable
3hiiA-5iysA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
5 / 12 TYR A 224
GLY A 137
SER A 138
VAL A 139
TYR A 249
None
None
None
FPS  A 506 (-4.3A)
FPS  A 506 (-4.2A)
1.38A 3hiiB-5iysA:
undetectable
3hiiB-5iysA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
3 / 3 THR A 191
LYS A 115
GLU A 188
None
0.95A 3ijdB-5iysA:
undetectable
3ijdB-5iysA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
4 / 8 TYR A 261
ARG A 125
ASP A 189
PHE A 193
None
1.02A 3mjrD-5iysA:
undetectable
3mjrD-5iysA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
4 / 6 GLU A 225
PHE A 228
GLU A 281
VAL A 282
None
1.35A 5h4dA-5iysA:
undetectable
5h4dA-5iysA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
5 / 12 VAL A  88
ASP A  86
THR A 111
GLY A  67
LEU A  68
None
1.42A 5m50B-5iysA:
undetectable
5m50B-5iysA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
4 / 5 LEU A 216
ALA A 220
LEU A 223
LEU A 253
None
0.85A 5vkqA-5iysA:
2.7
5vkqD-5iysA:
2.7
5vkqA-5iysA:
10.57
5vkqD-5iysA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
4 / 5 LEU A 253
LEU A 216
ALA A 220
LEU A 223
None
0.83A 5vkqA-5iysA:
2.7
5vkqB-5iysA:
2.7
5vkqA-5iysA:
10.57
5vkqB-5iysA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
4 / 5 LEU A 253
LEU A 216
ALA A 220
LEU A 223
None
0.81A 5vkqB-5iysA:
2.7
5vkqC-5iysA:
2.7
5vkqB-5iysA:
10.57
5vkqC-5iysA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
4 / 5 LEU A 253
LEU A 216
ALA A 220
LEU A 223
None
0.86A 5vkqC-5iysA:
2.7
5vkqD-5iysA:
2.7
5vkqC-5iysA:
10.57
5vkqD-5iysA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
5 / 12 VAL A 256
LEU A 128
LEU A 216
GLY A 175
LEU A 200
None
1.18A 6b0lB-5iysA:
undetectable
6b0lB-5iysA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
4 / 7 ASP A  56
ASP A  60
GLN A 113
GLN A 166
MG  A 505 (-2.5A)
MG  A 504 (-2.5A)
MG  A 504 (-3.9A)
FPS  A 507 (-3.9A)
0.50A 6g31A-5iysA:
11.6
6g31A-5iysA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_B_ZOLB401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
4 / 6 ASP A  56
ASP A  60
GLN A 113
GLN A 166
MG  A 505 (-2.5A)
MG  A 504 (-2.5A)
MG  A 504 (-3.9A)
FPS  A 507 (-3.9A)
0.56A 6g31B-5iysA:
11.4
6g31B-5iysA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
4 / 7 ASP A  56
ASP A  60
GLN A 113
GLN A 166
MG  A 505 (-2.5A)
MG  A 504 (-2.5A)
MG  A 504 (-3.9A)
FPS  A 507 (-3.9A)
0.55A 6g31D-5iysA:
11.2
6g31D-5iysA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
4 / 5 ASP A  56
ASP A  60
ARG A  53
GLN A 166
MG  A 505 (-2.5A)
MG  A 504 (-2.5A)
FPS  A 506 ( 3.1A)
FPS  A 507 (-3.9A)
0.77A 6g31F-5iysA:
11.5
6g31F-5iysA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_F_ZOLF401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
4 / 5 ASP A  56
ASP A  60
GLN A 113
GLN A 166
MG  A 505 (-2.5A)
MG  A 504 (-2.5A)
MG  A 504 (-3.9A)
FPS  A 507 (-3.9A)
0.73A 6g31F-5iysA:
11.5
6g31F-5iysA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
4 / 7 ASP A  56
ASP A  60
GLN A 113
GLN A 166
MG  A 505 (-2.5A)
MG  A 504 (-2.5A)
MG  A 504 (-3.9A)
FPS  A 507 (-3.9A)
0.64A 6g31G-5iysA:
3.2
6g31G-5iysA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_H_ZOLH401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
4 / 5 ASP A  56
ASP A  60
GLN A 113
GLN A 166
MG  A 505 (-2.5A)
MG  A 504 (-2.5A)
MG  A 504 (-3.9A)
FPS  A 507 (-3.9A)
0.63A 6g31H-5iysA:
11.5
6g31H-5iysA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
4 / 6 ASP A  56
ASP A  60
GLN A 113
GLN A 166
MG  A 505 (-2.5A)
MG  A 504 (-2.5A)
MG  A 504 (-3.9A)
FPS  A 507 (-3.9A)
0.56A 6g31J-5iysA:
9.2
6g31J-5iysA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
4 / 6 ASP A  56
ASP A  60
ARG A  53
GLN A 166
MG  A 505 (-2.5A)
MG  A 504 (-2.5A)
FPS  A 506 ( 3.1A)
FPS  A 507 (-3.9A)
0.85A 6g31L-5iysA:
9.3
6g31L-5iysA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
5iys PHYTOENE SYNTHASE
(Enterococcus
hirae)
4 / 6 ASP A  56
ASP A  60
GLN A 113
GLN A 166
MG  A 505 (-2.5A)
MG  A 504 (-2.5A)
MG  A 504 (-3.9A)
FPS  A 507 (-3.9A)
0.78A 6g31L-5iysA:
9.3
6g31L-5iysA:
14.88