SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iyx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 5iyx SOMATIC
EMBRYOGENESIS
RECEPTOR KINASE 1
(Arabidopsis
thaliana) 		5 / 12 LEU C  76
LEU C 100
LEU C 124
LEU C  33
LEU C  92
 None
 1.14A 1sqnB-5iyxC:
undetectable		 1sqnB-5iyxC:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5iyx SOMATIC
EMBRYOGENESIS
RECEPTOR KINASE 1
(Arabidopsis
thaliana) 		5 / 12 VAL C  86
LEU C  89
ILE C 133
LEU C 122
LEU C 146
 None
 1.06A 3cjtG-5iyxC:
undetectable		 3cjtG-5iyxC:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5iyx SOMATIC
EMBRYOGENESIS
RECEPTOR KINASE 1
(Arabidopsis
thaliana) 		5 / 12 ASP C 123
LEU C 122
ILE C 133
PRO C 134
LEU C 161
 None
 1.09A 4gh8A-5iyxC:
undetectable		 4gh8A-5iyxC:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5iyx SOMATIC
EMBRYOGENESIS
RECEPTOR KINASE 1
(Arabidopsis
thaliana) 		5 / 12 LEU C 100
LEU C  40
GLY C  83
HIS C  84
PHE C 129
 None
 1.42A 4pfjA-5iyxC:
undetectable		 4pfjA-5iyxC:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5iyx SOMATIC
EMBRYOGENESIS
RECEPTOR KINASE 1
(Arabidopsis
thaliana) 		4 / 8 LEU C  89
THR C  39
LEU C  40
LEU C  36
 None
 0.76A 4z90F-5iyxC:
undetectable
4z90G-5iyxC:
undetectable
4z90H-5iyxC:
undetectable
4z90I-5iyxC:
undetectable
4z90J-5iyxC:
undetectable		 4z90F-5iyxC:
21.54
4z90G-5iyxC:
21.54
4z90H-5iyxC:
21.54
4z90I-5iyxC:
21.54
4z90J-5iyxC:
21.54