SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iz3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5iz3 PREDICTED PROTEIN
(Physcomitrella
patens) 		5 / 9 LEU B 240
THR B 225
ILE B 219
THR B 253
ILE B 304
 None
 1.40A 1hzeA-5iz3B:
undetectable
1hzeB-5iz3B:
undetectable		 1hzeA-5iz3B:
20.00
1hzeB-5iz3B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5iz3 PREDICTED PROTEIN
(Physcomitrella
patens) 		5 / 9 THR B 253
ILE B 304
LEU B 240
THR B 225
ILE B 219
 None
 1.40A 1hzeA-5iz3B:
undetectable
1hzeB-5iz3B:
undetectable		 1hzeA-5iz3B:
20.00
1hzeB-5iz3B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5iz3 PREDICTED PROTEIN
(Physcomitrella
patens) 		5 / 12 VAL B 355
ASP B 360
ALA B 365
SER B 343
LEU B 379
 None
 1.36A 1kiaD-5iz3B:
undetectable		 1kiaD-5iz3B:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 5iz3 PREDICTED PROTEIN
(Physcomitrella
patens) 		5 / 12 GLY B 201
GLY B 172
GLY B 170
ASP B 211
ILE B 207
 None
 1.05A 2b25A-5iz3B:
undetectable		 2b25A-5iz3B:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 5iz3 PREDICTED PROTEIN
(Physcomitrella
patens) 		4 / 5 ILE B 111
LEU B 108
ASP B 178
ALA B 140
 None
 1.02A 2opxA-5iz3B:
undetectable		 2opxA-5iz3B:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5iz3 PREDICTED PROTEIN
(Physcomitrella
patens) 		5 / 11 GLY B 105
THR B 110
ILE B 111
LEU B 144
THR B 194
 None
 1.37A 3bexC-5iz3B:
undetectable
3bexD-5iz3B:
undetectable		 3bexC-5iz3B:
22.87
3bexD-5iz3B:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 5iz3 PREDICTED PROTEIN
(Physcomitrella
patens) 		5 / 10 LEU B 144
THR B 194
GLY B 105
THR B 110
ILE B 111
 None
 1.37A 3bexC-5iz3B:
undetectable
3bexD-5iz3B:
undetectable		 3bexC-5iz3B:
22.87
3bexD-5iz3B:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 5iz3 PREDICTED PROTEIN
(Physcomitrella
patens) 		5 / 10 GLY B 105
THR B 110
ILE B 111
LEU B 144
THR B 194
 None
 1.37A 3bexE-5iz3B:
undetectable
3bexF-5iz3B:
undetectable		 3bexE-5iz3B:
22.87
3bexF-5iz3B:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 5iz3 PREDICTED PROTEIN
(Physcomitrella
patens) 		5 / 11 LEU B 144
THR B 194
GLY B 105
THR B 110
ILE B 111
 None
 1.36A 3bexE-5iz3B:
undetectable
3bexF-5iz3B:
undetectable		 3bexE-5iz3B:
22.87
3bexF-5iz3B:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5iz3 PREDICTED PROTEIN
(Physcomitrella
patens) 		5 / 11 GLY B 105
THR B 110
ILE B 111
LEU B 144
THR B 194
 None
 1.40A 3bf1C-5iz3B:
undetectable
3bf1D-5iz3B:
undetectable		 3bf1C-5iz3B:
22.87
3bf1D-5iz3B:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 5iz3 PREDICTED PROTEIN
(Physcomitrella
patens) 		5 / 11 LEU B 144
THR B 194
GLY B 105
THR B 110
ILE B 111
 None
 1.38A 3bf1C-5iz3B:
undetectable
3bf1D-5iz3B:
undetectable		 3bf1C-5iz3B:
22.87
3bf1D-5iz3B:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 5iz3 PREDICTED PROTEIN
(Physcomitrella
patens) 		5 / 11 GLY B 105
THR B 110
ILE B 111
LEU B 144
THR B 194
 None
 1.34A 3bf1E-5iz3B:
undetectable
3bf1F-5iz3B:
undetectable		 3bf1E-5iz3B:
22.87
3bf1F-5iz3B:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 5iz3 PREDICTED PROTEIN
(Physcomitrella
patens) 		5 / 11 LEU B 144
THR B 194
GLY B 105
THR B 110
ILE B 111
 None
 1.41A 3bf1E-5iz3B:
undetectable
3bf1F-5iz3B:
undetectable		 3bf1E-5iz3B:
22.87
3bf1F-5iz3B:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5iz3 PREDICTED PROTEIN
(Physcomitrella
patens) 		3 / 3 TYR B 292
ASP B 181
ASP B 137
 PO4  B 402 (-4.8A)
None
None
 0.94A 3ou6B-5iz3B:
undetectable		 3ou6B-5iz3B:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5iz3 PREDICTED PROTEIN
(Physcomitrella
patens) 		4 / 7 PRO B 298
LEU B 332
LEU B 335
ILE B 219
 None
 1.04A 3u5jA-5iz3B:
undetectable		 3u5jA-5iz3B:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 5iz3 PREDICTED PROTEIN
(Physcomitrella
patens) 		4 / 5 GLU B 169
GLY B 170
TYR B 156
ASP B 202
 None
 1.39A 3w9tD-5iz3B:
undetectable		 3w9tD-5iz3B:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5iz3 PREDICTED PROTEIN
(Physcomitrella
patens) 		5 / 12 GLY B 221
PRO B 222
ILE B 111
GLY B 193
LEU B 180
 None
 0.99A 4n48A-5iz3B:
undetectable		 4n48A-5iz3B:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 5iz3 PREDICTED PROTEIN
(Physcomitrella
patens) 		4 / 7 GLY B 340
ALA B 339
THR B 236
SER B 215
 None
 0.82A 4r1zB-5iz3B:
undetectable		 4r1zB-5iz3B:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 5iz3 PREDICTED PROTEIN
(Physcomitrella
patens) 		3 / 3 ARG B 374
GLU B 258
TYR B 283
 None
 0.96A 4r29D-5iz3B:
undetectable		 4r29D-5iz3B:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5iz3 PREDICTED PROTEIN
(Physcomitrella
patens) 		4 / 7 TYR B 366
ILE B 310
GLY B 265
LEU B 323
 None
None
PO4  B 402 ( 4.1A)
None
 0.91A 5esmA-5iz3B:
undetectable		 5esmA-5iz3B:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 5iz3 PREDICTED PROTEIN
(Physcomitrella
patens) 		3 / 3 GLY B  81
LEU B  80
HIS B 249
 None
 0.70A 5u63A-5iz3B:
undetectable		 5u63A-5iz3B:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 5iz3 PREDICTED PROTEIN
(Physcomitrella
patens) 		3 / 3 GLY B  81
LEU B  80
HIS B 249
 None
 0.68A 5u63B-5iz3B:
undetectable		 5u63B-5iz3B:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 5iz3 PREDICTED PROTEIN
(Physcomitrella
patens) 		5 / 12 LEU B 323
VAL B 350
GLY B 367
ILE B 310
LEU B 351
 None
 1.10A 6dgxB-5iz3B:
undetectable		 6dgxB-5iz3B:
13.69