SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iz4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5iz4 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		7 / 11 GLY A  13
ALA A  15
SER A  16
ASP A  66
VAL A  67
ALA A  94
VAL A 119
 ADP  A 300 (-3.6A)
ADP  A 300 ( 3.9A)
ADP  A 300 (-2.5A)
ADP  A 300 (-3.5A)
ADP  A 300 (-3.8A)
ADP  A 300 (-3.5A)
ADP  A 300 (-4.1A)
 0.39A 1uayA-5iz4A:
29.1		 1uayA-5iz4A:
31.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5iz4 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		7 / 10 GLY A  13
ALA A  15
SER A  16
ASP A  66
VAL A  67
ALA A  94
VAL A 119
 ADP  A 300 (-3.6A)
ADP  A 300 ( 3.9A)
ADP  A 300 (-2.5A)
ADP  A 300 (-3.5A)
ADP  A 300 (-3.8A)
ADP  A 300 (-3.5A)
ADP  A 300 (-4.1A)
 0.39A 1uayB-5iz4A:
29.7		 1uayB-5iz4A:
31.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5iz4 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 10 GLY A  36
GLY A  19
THR A  22
ALA A  23
ALA A  20
 None
 1.13A 2ej3B-5iz4A:
undetectable		 2ej3B-5iz4A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 5iz4 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 12 ILE A 233
GLY A  19
ALA A  46
VAL A  49
PHE A  38
 None
None
None
None
ADP  A 300 (-3.5A)
 1.26A 2yvlC-5iz4A:
6.6		 2yvlC-5iz4A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5iz4 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A  13
ALA A  21
ASP A  66
VAL A  67
VAL A 119
 ADP  A 300 (-3.6A)
None
ADP  A 300 (-3.5A)
ADP  A 300 (-3.8A)
ADP  A 300 (-4.1A)
 0.94A 3dmfA-5iz4A:
2.5		 3dmfA-5iz4A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 5iz4 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 9 ALA A 253
LEU A 258
GLY A 257
LEU A 259
LEU A 156
 None
 0.90A 5dqfA-5iz4A:
undetectable		 5dqfA-5iz4A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5iz4 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		6 / 12 GLY A  95
VAL A 150
VAL A  49
ILE A  11
THR A  22
GLY A  17
 ADP  A 300 (-4.4A)
None
None
None
None
ADP  A 300 (-2.9A)
 1.27A 5hieD-5iz4A:
undetectable		 5hieD-5iz4A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5iz4 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		3 / 3 VAL A  33
GLN A  28
CYH A  53
 None
 0.81A 5icxA-5iz4A:
undetectable
5icxE-5iz4A:
undetectable		 5icxA-5iz4A:
21.05
5icxE-5iz4A:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 5iz4 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 12 SER A 152
LEU A 153
THR A 159
GLY A 195
VAL A 197
 None
 0.94A 5jo9A-5iz4A:
26.4		 5jo9A-5iz4A:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 5iz4 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 12 ALA A 154
ASN A 120
SER A 152
GLY A 160
SER A 161
 None
 1.08A 6c79A-5iz4A:
undetectable		 6c79A-5iz4A:
17.06