SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iz5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		4 / 5 LEU B 606
SER B 658
LEU B 463
GLY B 489
 None
 1.14A 1a4lB-5iz5B:
undetectable		 1a4lB-5iz5B:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		5 / 11 ILE B 796
ASP B 352
LEU B 351
GLY B 349
VAL B 354
 None
 1.33A 1axwB-5iz5B:
undetectable		 1axwB-5iz5B:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		5 / 12 LEU B 338
SER B 363
SER B 358
HIS B 729
LEU B 683
 None
 1.33A 1db1A-5iz5B:
undetectable		 1db1A-5iz5B:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		4 / 5 THR B 336
LEU B 338
GLY B 362
TYR B 674
 None
 1.38A 1gtiF-5iz5B:
undetectable		 1gtiF-5iz5B:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_0
(NEURAMINIDASE)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		5 / 12 GLU B 290
LEU B 286
ARG B 664
ARG B 297
TYR B 486
 None
 1.49A 1l7hA-5iz5B:
undetectable		 1l7hA-5iz5B:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		4 / 8 SER B 363
THR B 364
LEU B 461
GLU B 290
 None
 1.11A 1mxgA-5iz5B:
undetectable		 1mxgA-5iz5B:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		4 / 5 ASP B 110
VAL B  87
ASP B 620
GLN B 613
 None
 1.24A 1n2xB-5iz5B:
3.4		 1n2xB-5iz5B:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		5 / 12 LEU B 338
SER B 363
SER B 358
HIS B 729
LEU B 683
 None
 1.31A 1rk3A-5iz5B:
undetectable		 1rk3A-5iz5B:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		5 / 11 VAL B  28
TYR B  46
GLU B  30
LEU B  34
ILE B  92
 None
 1.35A 1t6zB-5iz5B:
undetectable		 1t6zB-5iz5B:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		3 / 3 LEU B 606
PHE B 490
ARG B 601
 None
None
SO4  B 909 (-3.8A)
 0.81A 1xdkF-5iz5B:
undetectable		 1xdkF-5iz5B:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_B_RBFB202_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		5 / 11 TYR B 493
GLU B 479
PHE B 477
VAL B 155
GLU B 640
 None
 1.39A 2fl5A-5iz5B:
undetectable
2fl5B-5iz5B:
undetectable
2fl5F-5iz5B:
undetectable		 2fl5A-5iz5B:
14.71
2fl5B-5iz5B:
15.36
2fl5F-5iz5B:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_H_RBFH201_1
(IMMUNOGLOBULIN IGG1
HEAVY CHAIN
IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		5 / 9 GLU B 640
TYR B 493
GLU B 479
PHE B 477
VAL B 155
 None
 1.43A 2fl5D-5iz5B:
0.0
2fl5H-5iz5B:
0.8
2fl5L-5iz5B:
1.8		 2fl5D-5iz5B:
15.36
2fl5H-5iz5B:
15.36
2fl5L-5iz5B:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		4 / 4 LEU B 459
PRO B 460
LEU B 461
ARG B 661
 None
 1.43A 2qd2A-5iz5B:
4.7		 2qd2A-5iz5B:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		5 / 12 PHE B 672
ALA B 308
LEU B 309
VAL B 323
GLY B 324
 None
 1.06A 2ve3A-5iz5B:
undetectable		 2ve3A-5iz5B:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		5 / 12 VAL B 354
PHE B 357
SER B 358
SER B 655
THR B 654
 None
 1.13A 2x2iA-5iz5B:
undetectable		 2x2iA-5iz5B:
22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		5 / 12 VAL B 354
PHE B 357
SER B 358
SER B 655
THR B 654
 None
 1.11A 2x2iC-5iz5B:
undetectable		 2x2iC-5iz5B:
22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		3 / 3 PRO B 765
GLU B 775
TYR B 773
 None
 0.81A 2zmbA-5iz5B:
undetectable		 2zmbA-5iz5B:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		4 / 7 PHE B 209
LEU B 189
LEU B 244
LEU B 219
 None
 0.91A 3bgdB-5iz5B:
undetectable		 3bgdB-5iz5B:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		3 / 3 SER B 622
ASP B 630
ASP B 110
 None
 0.88A 3iv6A-5iz5B:
undetectable		 3iv6A-5iz5B:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		3 / 3 SER B 622
ASP B 630
ASP B 110
 None
 0.92A 3iv6C-5iz5B:
undetectable		 3iv6C-5iz5B:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		4 / 7 TYR B 766
GLU B 779
LEU B 759
ASN B 734
 None
 1.35A 3k8mB-5iz5B:
undetectable		 3k8mB-5iz5B:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		5 / 12 LEU B 782
GLY B 340
SER B 337
LEU B 381
ALA B 368
 None
 1.24A 3ou6C-5iz5B:
undetectable		 3ou6C-5iz5B:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		5 / 12 LEU B 338
SER B 363
SER B 358
HIS B 729
LEU B 683
 None
 1.31A 3vt3A-5iz5B:
undetectable		 3vt3A-5iz5B:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		5 / 12 LEU B 338
SER B 363
SER B 358
HIS B 729
LEU B 683
 None
 1.31A 3vt7A-5iz5B:
undetectable		 3vt7A-5iz5B:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		5 / 12 LEU B 797
VAL B 323
PHE B 730
LEU B 345
VAL B 354
 None
 1.07A 3w68D-5iz5B:
undetectable		 3w68D-5iz5B:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		4 / 6 THR B 364
GLY B 359
ARG B 333
LEU B 463
 None
 1.25A 4ac9C-5iz5B:
3.3		 4ac9C-5iz5B:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		4 / 6 THR B 364
GLY B 359
ARG B 333
LEU B 463
 None
 1.23A 4acaC-5iz5B:
undetectable		 4acaC-5iz5B:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		3 / 3 SER B 532
TYR B 650
PRO B 597
 None
 0.96A 4kbeB-5iz5B:
2.3		 4kbeB-5iz5B:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		4 / 5 ASN B 653
ALA B 649
GLY B 329
ASP B 758
 None
 0.95A 4n48A-5iz5B:
undetectable		 4n48A-5iz5B:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		5 / 10 LEU B 342
LEU B 351
ASN B 457
LEU B 452
LEU B 459
 None
 1.18A 4po0A-5iz5B:
undetectable		 4po0A-5iz5B:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		4 / 7 LYS B 619
TYR B 627
TYR B 109
LEU B 108
 None
 1.14A 4yv5A-5iz5B:
0.8		 4yv5A-5iz5B:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		4 / 7 LYS B 619
TYR B 627
TYR B 109
LEU B 108
 None
 1.03A 4yv5B-5iz5B:
undetectable		 4yv5B-5iz5B:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		5 / 12 GLY B 329
GLY B 331
THR B 366
GLU B 681
LEU B 338
 None
None
SO4  B 910 (-4.6A)
None
None
 1.14A 5bw4A-5iz5B:
undetectable		 5bw4A-5iz5B:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		4 / 5 SER B 337
ALA B 334
HIS B 341
LEU B 732
 None
 1.03A 5dzkb-5iz5B:
undetectable
5dzkp-5iz5B:
undetectable		 5dzkb-5iz5B:
13.54
5dzkp-5iz5B:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		4 / 5 SER B 337
ALA B 334
HIS B 341
LEU B 732
 None
 1.07A 5dzkc-5iz5B:
undetectable
5dzkq-5iz5B:
undetectable		 5dzkc-5iz5B:
13.54
5dzkq-5iz5B:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		4 / 5 SER B 337
ALA B 334
HIS B 341
LEU B 732
 None
 1.15A 5dzkf-5iz5B:
undetectable
5dzkt-5iz5B:
undetectable		 5dzkf-5iz5B:
13.54
5dzkt-5iz5B:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		4 / 6 SER B 337
ALA B 334
HIS B 341
LEU B 732
 None
 1.05A 5dzkg-5iz5B:
undetectable
5dzku-5iz5B:
undetectable		 5dzkg-5iz5B:
13.54
5dzku-5iz5B:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		3 / 3 PRO B  45
LEU B 134
SER B  68
 None
 0.61A 5fsaB-5iz5B:
undetectable		 5fsaB-5iz5B:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		3 / 3 THR B  67
THR B  61
LEU B 134
 None
 0.68A 5m66D-5iz5B:
2.8		 5m66D-5iz5B:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		4 / 5 LEU B  51
LEU B  88
MET B 632
GLN B 610
 None
 1.28A 5uc3A-5iz5B:
undetectable		 5uc3A-5iz5B:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		5 / 8 GLY B 419
ARG B 642
GLN B 607
TYR B 193
ASP B 426
 None
 1.49A 5vlmB-5iz5B:
undetectable		 5vlmB-5iz5B:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		4 / 7 TRP B 527
SER B 602
GLY B 503
ARG B 601
 None
SO4  B 909 (-2.2A)
None
SO4  B 909 (-3.8A)
 1.06A 6btxA-5iz5B:
undetectable		 6btxA-5iz5B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		5 / 12 LEU B 348
GLY B 349
VAL B 320
CYH B 353
VAL B 301
 None
 1.33A 6bxlB-5iz5B:
undetectable		 6bxlB-5iz5B:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		4 / 6 GLY B 233
ASN B 229
SER B 225
ARG B 224
 None
 1.08A 6dwdA-5iz5B:
undetectable
6dwdC-5iz5B:
undetectable		 6dwdA-5iz5B:
20.48
6dwdC-5iz5B:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens) 		3 / 3 ARG B 510
PHE B 507
GLY B 509
 None
 0.77A 6fgdA-5iz5B:
undetectable		 6fgdA-5iz5B:
19.90