SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5izd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		5 / 9 THR A 330
GLY A 348
ALA A 337
THR A 366
ILE A 344
 None
 1.24A 1c9sJ-5izdA:
undetectable
1c9sK-5izdA:
undetectable		 1c9sJ-5izdA:
10.81
1c9sK-5izdA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		3 / 3 TRP A  56
ARG A 157
THR A 165
 None
 0.88A 1df7A-5izdA:
undetectable		 1df7A-5izdA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		4 / 8 THR A 146
LEU A 171
VAL A 185
VAL A 104
 None
 1.15A 1dz9A-5izdA:
undetectable		 1dz9A-5izdA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		5 / 9 THR A 330
GLY A 348
ALA A 337
THR A 366
ILE A 344
 None
 1.23A 1gtfE-5izdA:
undetectable
1gtfF-5izdA:
undetectable		 1gtfE-5izdA:
10.81
1gtfF-5izdA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		4 / 6 LEU A 220
GLY A 140
LYS A 469
TYR A 139
 None
 1.33A 1gtiC-5izdA:
undetectable		 1gtiC-5izdA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		4 / 5 LEU A 220
GLY A 140
LYS A 469
TYR A 139
 None
 1.34A 1gtiF-5izdA:
undetectable		 1gtiF-5izdA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1URM_A_BEZA201_0
(PEROXIREDOXIN 5)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		5 / 9 PRO A 151
THR A 177
PRO A 178
GLY A 179
SER A 180
 None
 1.29A 1urmA-5izdA:
2.3		 1urmA-5izdA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		4 / 8 THR A 146
LEU A 171
VAL A 185
VAL A 104
 None
 1.16A 1uyuA-5izdA:
undetectable		 1uyuA-5izdA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		4 / 8 THR A 146
LEU A 171
VAL A 185
VAL A 104
 None
 1.18A 1uyuB-5izdA:
undetectable		 1uyuB-5izdA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		4 / 6 LEU A 171
ASN A  90
LYS A 158
ILE A 184
 None
 1.15A 2jn3A-5izdA:
undetectable		 2jn3A-5izdA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		3 / 3 VAL A 101
ASP A 102
GLU A  83
 None
 0.70A 2qeuA-5izdA:
undetectable		 2qeuA-5izdA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		3 / 3 VAL A 101
ASP A 102
GLU A  83
 None
 0.68A 2qeuC-5izdA:
undetectable		 2qeuC-5izdA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		5 / 12 LEU A 327
GLY A 348
GLY A 347
THR A 366
LEU A 321
 None
 1.20A 2uvnA-5izdA:
undetectable		 2uvnA-5izdA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		5 / 11 PRO A 151
THR A 177
GLY A 179
THR A   3
LEU A 171
 None
 1.25A 2uvnB-5izdA:
0.7		 2uvnB-5izdA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		5 / 12 LEU A 310
GLY A 319
ALA A 277
SER A 349
GLY A 348
 None
 1.05A 2vmyA-5izdA:
undetectable		 2vmyA-5izdA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		4 / 6 VAL A 395
TYR A 399
ASP A 417
TRP A 257
 None
 0.97A 2x45A-5izdA:
undetectable		 2x45A-5izdA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		4 / 7 VAL A 395
TYR A 399
ASP A 417
TRP A 257
 None
 0.96A 2x45B-5izdA:
undetectable		 2x45B-5izdA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		4 / 7 VAL A 395
TYR A 399
ASP A 417
TRP A 257
 None
 0.96A 2x45C-5izdA:
undetectable		 2x45C-5izdA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		3 / 3 THR A 229
SER A 174
LYS A 172
 NAP  A 601 (-3.3A)
NAP  A 601 (-3.4A)
NAP  A 601 (-3.0A)
 1.10A 3aocC-5izdA:
1.7		 3aocC-5izdA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		4 / 7 VAL A 395
TYR A 399
ASP A 417
TRP A 257
 None
 0.94A 3bu1A-5izdA:
undetectable		 3bu1A-5izdA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		5 / 12 SER A  16
GLU A 207
VAL A 170
ASP A  41
ILE A 201
 None
 1.48A 3jayA-5izdA:
undetectable		 3jayA-5izdA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		5 / 10 ALA A 162
GLY A 140
ILE A 141
VAL A 193
LEU A 163
 None
 1.01A 3ogpA-5izdA:
undetectable		 3ogpA-5izdA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		5 / 9 ILE A  67
ILE A  68
ALA A 162
LEU A 163
ALA A 191
 None
 1.05A 3ozvB-5izdA:
4.9		 3ozvB-5izdA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		4 / 6 ALA A 424
ILE A 420
LEU A 413
ALA A 402
 None
 0.86A 3r9sC-5izdA:
undetectable		 3r9sC-5izdA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		4 / 5 SER A 175
GLY A 225
GLU A 458
GLU A 247
 NAP  A 601 (-2.6A)
NAP  A 601 (-3.4A)
None
None
 1.41A 3raeB-5izdA:
undetectable
3raeD-5izdA:
1.9		 3raeB-5izdA:
22.20
3raeD-5izdA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		4 / 7 TRP A 148
GLY A 249
GLY A 250
GLU A 247
 NAP  A 601 (-4.0A)
None
None
None
 1.08A 4fgkB-5izdA:
2.5		 4fgkB-5izdA:
18.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FR8_A_TNGA601_1
(ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		5 / 11 ASN A 149
PHE A 150
MET A 154
SER A 280
CYH A 281
 None
 0.50A 4fr8A-5izdA:
55.3		 4fr8A-5izdA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		4 / 8 THR A 146
LEU A 171
VAL A 185
VAL A 104
 None
 1.17A 4l4eA-5izdA:
undetectable		 4l4eA-5izdA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		4 / 8 THR A 146
LEU A 171
VAL A 185
VAL A 104
 None
 1.15A 4l4fA-5izdA:
undetectable		 4l4fA-5izdA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		4 / 5 ILE A  85
LEU A  82
GLU A 182
VAL A 189
 None
 1.01A 4nkxB-5izdA:
undetectable		 4nkxB-5izdA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		3 / 3 GLY A 319
PRO A 320
GLN A 279
 None
 0.36A 4oltB-5izdA:
undetectable		 4oltB-5izdA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		3 / 3 GLY A 319
PRO A 320
GLN A 279
 None
 0.19A 4qwpB-5izdA:
undetectable		 4qwpB-5izdA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		5 / 9 ILE A 201
ASP A  47
ALA A  49
THR A 168
VAL A 143
 None
 1.00A 4r1zA-5izdA:
undetectable		 4r1zA-5izdA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		4 / 7 ALA A 160
ILE A 184
LEU A 198
PHE A 188
 None
 1.09A 4uymA-5izdA:
undetectable		 4uymA-5izdA:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		5 / 12 GLY A 103
ASN A 149
PHE A 150
MET A 154
CYH A 281
 None
 0.75A 5fhzA-5izdA:
54.5		 5fhzA-5izdA:
31.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		5 / 12 GLY A 103
ASN A 149
MET A 154
GLU A 247
CYH A 281
 None
 0.80A 5fhzD-5izdA:
52.6		 5fhzD-5izdA:
31.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		4 / 6 ILE A  67
VAL A 197
VAL A 193
TRP A  56
 None
 0.96A 5jwaH-5izdA:
undetectable		 5jwaH-5izdA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		4 / 7 LEU A 409
SER A 405
ILE A 382
GLU A 381
 None
 0.87A 5n5dA-5izdA:
5.6		 5n5dA-5izdA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		3 / 3 TRP A 183
ILE A  75
GLU A 100
 None
 0.81A 6hcxA-5izdA:
undetectable		 6hcxA-5izdA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))
(Thermoplasma
acidophilum) 		4 / 5 ARG A 157
MET A 223
THR A 222
LEU A 145
 None
None
None
NAP  A 601 (-4.1A)
 1.40A 6nknW-5izdA:
undetectable		 6nknW-5izdA:
8.82