SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ize'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EL4_A_ROCA100_2 (PROTEASE)	5ize	RNA-DIRECTED RNA POLYMERASE L (Hantaan orthohantavirus)	5 / 9	ALA A 90 GLY A 131 ILE A 135 PRO A 96 THR A 95	None	1.11A	3el4B-5izeA: undetectable	3el4B-5izeA: 24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HZN_D_ACTD229_0 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	5ize	RNA-DIRECTED RNA POLYMERASE L (Hantaan orthohantavirus)	4 / 4	ASP A 116 GLY A 120 LYS A 119 GLU A 123	None	1.35A	3hznD-5izeA: undetectable	3hznD-5izeA: 19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FU9_A_ACTA311_0 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)	5ize	RNA-DIRECTED RNA POLYMERASE L (Hantaan orthohantavirus)	3 / 3	GLN A 171 THR A 170 THR A 169	None	0.77A	4fu9A-5izeA: undetectable	4fu9A-5izeA: 22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FUF_A_ACTA310_0 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)	5ize	RNA-DIRECTED RNA POLYMERASE L (Hantaan orthohantavirus)	3 / 3	GLN A 171 THR A 170 THR A 169	None	0.76A	4fufA-5izeA: undetectable	4fufA-5izeA: 22.66

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3EL4_A_ROCA100_2","PROTEASE;PROTEASE","5ize","RNA-DIRECTED RNA POLYMERASE L","Hantaan orthohantavirus",5,"ALA A  90;GLY A 131;ILE A 135;PRO A  96;THR A  95","None","1.11A","3el4B-5izeA:undetectable","3el4B-5izeA:24.73"],["3HZN_D_ACTD229_0","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","5ize","RNA-DIRECTED RNA POLYMERASE L","Hantaan orthohantavirus",4,"ASP A 116;GLY A 120;LYS A 119;GLU A 123","None","1.35A","3hznD-5izeA:undetectable","3hznD-5izeA:19.82"],["4FU9_A_ACTA311_0","UROKINASE-TYPE PLASMINOGEN ACTIVATOR","5ize","RNA-DIRECTED RNA POLYMERASE L","Hantaan orthohantavirus",3,"GLN A 171;THR A 170;THR A 169","None","0.77A","4fu9A-5izeA:undetectable","4fu9A-5izeA:22.66"],["4FUF_A_ACTA310_0","UROKINASE-TYPE PLASMINOGEN ACTIVATOR","5ize","RNA-DIRECTED RNA POLYMERASE L","Hantaan orthohantavirus",3,"GLN A 171;THR A 170;THR A 169","None","0.76A","4fufA-5izeA:undetectable","4fufA-5izeA:22.66"]]