SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5izh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 5izh RNA-DIRECTED RNA
POLYMERASE L
(Lassa
mammarenavirus) 		4 / 5 GLU A  51
LEU A  45
LEU A  48
LEU A  46
 None
 1.03A 1np1A-5izhA:
undetectable		 1np1A-5izhA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 5izh RNA-DIRECTED RNA
POLYMERASE L
(Lassa
mammarenavirus) 		5 / 10 LEU A  93
LEU A  73
LEU A 130
LYS A 131
LEU A  98
 None
 1.13A 2xn6A-5izhA:
undetectable
2xn6B-5izhA:
undetectable		 2xn6A-5izhA:
19.31
2xn6B-5izhA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 5izh RNA-DIRECTED RNA
POLYMERASE L
(Lassa
mammarenavirus) 		5 / 12 LEU A 123
GLY A  90
ILE A  99
GLY A  59
ASP A  89
 None
 0.93A 3bwcB-5izhA:
undetectable		 3bwcB-5izhA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5izh RNA-DIRECTED RNA
POLYMERASE L
(Lassa
mammarenavirus) 		4 / 7 PRO A  88
LEU A 126
LEU A 130
ILE A  72
 None
 0.82A 3u5jA-5izhA:
4.6		 3u5jA-5izhA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5izh RNA-DIRECTED RNA
POLYMERASE L
(Lassa
mammarenavirus) 		4 / 8 PRO A  88
LEU A 126
LEU A 130
ILE A  72
 None
 0.79A 3u5kA-5izhA:
4.6		 3u5kA-5izhA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5izh RNA-DIRECTED RNA
POLYMERASE L
(Lassa
mammarenavirus) 		4 / 7 PRO A  88
LEU A 126
LEU A 130
ILE A  72
 None
 0.92A 3u5kB-5izhA:
4.4		 3u5kB-5izhA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5izh RNA-DIRECTED RNA
POLYMERASE L
(Lassa
mammarenavirus) 		4 / 8 PRO A  88
LEU A 126
LEU A 130
ILE A  72
 None
 0.87A 3u5kC-5izhA:
4.3		 3u5kC-5izhA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5izh RNA-DIRECTED RNA
POLYMERASE L
(Lassa
mammarenavirus) 		4 / 8 PRO A  88
LEU A 126
LEU A 130
ILE A  72
 None
 0.92A 3u5kD-5izhA:
4.5		 3u5kD-5izhA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5izh RNA-DIRECTED RNA
POLYMERASE L
(Lassa
mammarenavirus) 		5 / 12 LEU A 160
ARG A 161
LEU A  39
SER A  47
LEU A  46
 None
 0.90A 4o1zB-5izhA:
undetectable		 4o1zB-5izhA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5izh RNA-DIRECTED RNA
POLYMERASE L
(Lassa
mammarenavirus) 		4 / 8 PRO A  88
LEU A 126
LEU A 130
ILE A  72
 None
 0.90A 5y1yA-5izhA:
4.3		 5y1yA-5izhA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5izh RNA-DIRECTED RNA
POLYMERASE L
(Lassa
mammarenavirus) 		3 / 3 ILE A 138
ASN A  58
CYH A 103
 None
 0.89A 6bp4A-5izhA:
undetectable		 6bp4A-5izhA:
22.83