SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5izk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 10 ASP A 254
GLY A 253
MET A 270
VAL A 267
ILE A 250
 None
 1.33A 1fohA-5izkA:
undetectable		 1fohA-5izkA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 9 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 1.01A 1hpvB-5izkA:
undetectable		 1hpvB-5izkA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 10 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 0.95A 1hsgA-5izkA:
undetectable		 1hsgA-5izkA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		4 / 7 PHE A 293
VAL A 228
VAL A 256
ILE A 258
 None
 0.97A 1p7rA-5izkA:
undetectable		 1p7rA-5izkA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_2
(PROTEASE RETROPEPSIN)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 11 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 0.97A 1t3rB-5izkA:
undetectable		 1t3rB-5izkA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 12 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 0.96A 2f80B-5izkA:
undetectable		 2f80B-5izkA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 12 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 1.00A 2f81A-5izkA:
undetectable		 2f81A-5izkA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 9 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 0.98A 2o4pB-5izkA:
undetectable		 2o4pB-5izkA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 9 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 1.07A 2q5kA-5izkA:
undetectable		 2q5kA-5izkA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 11 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 1.00A 2qhcA-5izkA:
undetectable		 2qhcA-5izkA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 9 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 1.01A 3ekvB-5izkA:
undetectable		 3ekvB-5izkA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 12 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 0.99A 3k4vC-5izkA:
undetectable		 3k4vC-5izkA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 11 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 1.03A 3lzvB-5izkA:
undetectable		 3lzvB-5izkA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 12 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 0.97A 3mwsB-5izkA:
undetectable		 3mwsB-5izkA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 10 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 1.06A 3nu6B-5izkA:
undetectable		 3nu6B-5izkA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 10 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 1.02A 3oxvB-5izkA:
undetectable		 3oxvB-5izkA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 11 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 0.99A 3oxvD-5izkA:
undetectable		 3oxvD-5izkA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 10 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 1.04A 3oxwD-5izkA:
undetectable		 3oxwD-5izkA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 12 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 0.95A 3pwrB-5izkA:
undetectable		 3pwrB-5izkA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 12 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 0.93A 3tkgD-5izkA:
undetectable		 3tkgD-5izkA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 10 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 0.97A 4dqcA-5izkA:
undetectable		 4dqcA-5izkA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 11 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 0.96A 4dqeA-5izkA:
undetectable		 4dqeA-5izkA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 11 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 0.96A 4dqhA-5izkA:
undetectable		 4dqhA-5izkA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 11 SER A 431
PHE A 351
PHE A 350
LEU A 329
GLN A 409
 None
 1.49A 4dx7A-5izkA:
undetectable		 4dx7A-5izkA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 9 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 0.96A 4ll3B-5izkA:
undetectable		 4ll3B-5izkA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 12 GLY A 134
LEU A  13
MET A 113
VAL A  10
ILE A 100
 None
 1.41A 4okbA-5izkA:
undetectable		 4okbA-5izkA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 10 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 1.01A 4q1wB-5izkA:
undetectable		 4q1wB-5izkA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		6 / 12 ALA A 412
ILE A 136
VAL A 319
LEU A 329
ALA A 445
PHE A 335
 None
 1.34A 4tyjA-5izkA:
undetectable		 4tyjA-5izkA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		4 / 5 PHE A 416
PRO A 419
VAL A 420
ALA A 314
 None
 1.25A 4z4dA-5izkA:
undetectable		 4z4dA-5izkA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		4 / 5 PHE A 416
PRO A 419
VAL A 420
ALA A 314
 None
 1.25A 4z4eA-5izkA:
undetectable		 4z4eA-5izkA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 12 ALA A 186
ALA A 185
LEU A  23
ALA A  22
ILE A 181
 GDP  A1001 ( 4.5A)
GDP  A1001 ( 4.4A)
None
GDP  A1001 (-3.8A)
None
 0.91A 6a5yD-5izkA:
undetectable		 6a5yD-5izkA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR
(Homo
sapiens) 		5 / 10 ALA A 315
VAL A 428
GLY A 346
VAL A 319
ILE A 317
 None
 0.99A 6dj2A-5izkA:
undetectable		 6dj2A-5izkA:
9.64