SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5izt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5izt OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		5 / 10 TYR A 387
ALA A 385
LEU A 301
MET A 285
GLY A 282
 None
 1.07A 1uhoA-5iztA:
undetectable		 1uhoA-5iztA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 5izt OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		5 / 12 MET A 285
ILE A 284
LEU A 288
LEU A 393
ALA A 365
 None
 1.06A 3a50D-5iztA:
undetectable		 3a50D-5iztA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 5izt OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		4 / 6 HIS A 295
ASN A 292
ASN A 294
GLU A 291
 None
 1.32A 3galA-5iztA:
undetectable		 3galA-5iztA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 5izt OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		4 / 6 HIS A 295
ASN A 292
ASN A 294
GLU A 291
 None
 1.33A 3galB-5iztA:
undetectable		 3galB-5iztA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5izt OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		4 / 6 ILE A 323
GLU A 201
LYS A 199
ASN A 200
 None
 1.48A 3kp6A-5iztA:
1.7
3kp6B-5iztA:
1.5		 3kp6A-5iztA:
18.34
3kp6B-5iztA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 5izt OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		5 / 10 ALA A 232
ILE A 298
ILE A 388
LEU A 368
ILE A 284
 None
 1.19A 4dtaA-5iztA:
undetectable		 4dtaA-5iztA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 5izt OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		3 / 3 ARG A 220
GLU A 221
PHE A 226
 None
 0.96A 4kszA-5iztA:
undetectable		 4kszA-5iztA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 5izt OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		5 / 10 TYR A 392
LEU A 288
LEU A 384
GLY A 282
MET A 285
 None
 1.48A 4zp0A-5iztA:
2.4		 4zp0A-5iztA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5izt OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		3 / 3 MET A 396
GLN A 397
ARG A 400
 None
 0.96A 5ewzB-5iztA:
3.1		 5ewzB-5iztA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5izt OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		3 / 3 MET A 396
GLN A 397
ARG A 400
 None
 0.90A 5m35B-5iztA:
3.2		 5m35B-5iztA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5izt OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		3 / 3 MET A 396
GLN A 397
ARG A 400
 None
 0.91A 5m36A-5iztA:
3.7		 5m36A-5iztA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5izt OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		3 / 3 GLN A 364
TYR A 392
ASN A 395
 None
 0.89A 6dwdC-5iztA:
undetectable		 6dwdC-5iztA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5izt OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		3 / 3 MET A 396
GLN A 397
ARG A 400
 None
 0.91A 6fn9A-5iztA:
4.1		 6fn9A-5iztA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5izt OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		3 / 3 MET A 396
GLN A 397
ARG A 400
 None
 0.92A 6fnaB-5iztA:
2.2		 6fnaB-5iztA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5izt OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		3 / 3 MET A 396
GLN A 397
ARG A 400
 None
 0.91A 6fnbA-5iztA:
2.1		 6fnbA-5iztA:
20.25